Organic electroluminescent materials and devices

ABSTRACT

Compounds comprising a ligand L A  selected from the group consisting of Formula I and Formula II may be useful as blue phosphorescent materials in OLED devices. The materials were determined computationally to have appropriate triplet energies for use as blue emitters and to possess sufficient chemical stability for use in devices.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority to U.S. Provisional Patent Application Ser. No. 62/260,812, filed Nov. 30, 2015, the entire contents of which is incorporated herein by reference.

PARTIES TO A JOINT RESEARCH AGREEMENT

The claimed invention was made by, on behalf of, and/or in connection with one or more of the following parties to a joint university corporation research agreement: The Regents of the University of Michigan, Princeton University, University of Southern California, and the Universal Display Corporation. The agreement was in effect on and before the date the claimed invention was made, and the claimed invention was made as a result of activities undertaken within the scope of the agreement.

FIELD

The present invention relates to compounds for use as emitters, and devices, such as organic light emitting diodes, including the same.

BACKGROUND

Opto-electronic devices that make use of organic materials are becoming increasingly desirable for a number of reasons. Many of the materials used to make such devices are relatively inexpensive, so organic opto-electronic devices have the potential for cost advantages over inorganic devices. In addition, the inherent properties of organic materials, such as their flexibility, may make them well suited for particular applications such as fabrication on a flexible substrate. Examples of organic opto-electronic devices include organic light emitting diodes/devices (OLEDs), organic phototransistors, organic photovoltaic cells, and organic photodetectors. For OLEDs, the organic materials may have performance advantages over conventional materials. For example, the wavelength at which an organic emissive layer emits light may generally be readily tuned with appropriate dopants.

OLEDs make use of thin organic films that emit light when voltage is applied across the device. OLEDs are becoming an increasingly interesting technology for use in applications such as flat panel displays, illumination, and backlighting. Several OLED materials and configurations are described in U.S. Pat. Nos. 5,844,363, 6,303,238, and 5,707,745, which are incorporated herein by reference in their entirety.

One application for phosphorescent emissive molecules is a full color display. Industry standards for such a display call for pixels adapted to emit particular colors, referred to as “saturated” colors. In particular, these standards call for saturated red, green, and blue pixels. Alternatively the OLED can be designed to emit white light. In conventional liquid crystal displays emission from a white backlight is filtered using absorption filters to produce red, green and blue emission. The same technique can also be used with OLEDs. The white OLED can be either a single EML device or a stack structure. Color may be measured using CIE coordinates, which are well known to the art.

One example of a green emissive molecule is tris(2-phenylpyridine) iridium, denoted Ir(ppy)₃, which has the following structure:

In this, and later figures herein, we depict the dative bond from nitrogen to metal (here, Ir) as a straight line.

As used herein, the term “organic” includes polymeric materials as well as small molecule organic materials that may be used to fabricate organic opto-electronic devices. “Small molecule” refers to any organic material that is not a polymer, and “small molecules” may actually be quite large. Small molecules may include repeat units in some circumstances. For example, using a long chain alkyl group as a substituent does not remove a molecule from the “small molecule” class. Small molecules may also be incorporated into polymers, for example as a pendent group on a polymer backbone or as a part of the backbone. Small molecules may also serve as the core moiety of a dendrimer, which consists of a series of chemical shells built on the core moiety. The core moiety of a dendrimer may be a fluorescent or phosphorescent small molecule emitter. A dendrimer may be a “small molecule,” and it is believed that all dendrimers currently used in the field of OLEDs are small molecules.

As used herein, “top” means furthest away from the substrate, while “bottom” means closest to the substrate. Where a first layer is described as “disposed over” a second layer, the first layer is disposed further away from substrate. There may be other layers between the first and second layer, unless it is specified that the first layer is “in contact with” the second layer. For example, a cathode may be described as “disposed over” an anode, even though there are various organic layers in between.

As used herein, “solution processible” means capable of being dissolved, dispersed, or transported in and/or deposited from a liquid medium, either in solution or suspension form.

A ligand may be referred to as “photoactive” when it is believed that the ligand directly contributes to the photoactive properties of an emissive material. A ligand may be referred to as “ancillary” when it is believed that the ligand does not contribute to the photoactive properties of an emissive material, although an ancillary ligand may alter the properties of a photoactive ligand

As used herein, and as would be generally understood by one skilled in the art, a first “Highest Occupied Molecular Orbital” (HOMO) or “Lowest Unoccupied Molecular Orbital” (LUMO) energy level is “greater than” or “higher than” a second HOMO or LUMO energy level if the first energy level is closer to the vacuum energy level. Since ionization potentials (IP) are measured as a negative energy relative to a vacuum level, a higher HOMO energy level corresponds to an IP having a smaller absolute value (an IP that is less negative). Similarly, a higher LUMO energy level corresponds to an electron affinity (EA) having a smaller absolute value (an EA that is less negative). On a conventional energy level diagram, with the vacuum level at the top, the LUMO energy level of a material is higher than the HOMO energy level of the same material. A “higher” HOMO or LUMO energy level appears closer to the top of such a diagram than a “lower” HOMO or LUMO energy level.

As used herein, and as would be generally understood by one skilled in the art, a first work function is “greater than” or “higher than” a second work function if the first work function has a higher absolute value. Because work functions are generally measured as negative numbers relative to vacuum level, this means that a “higher” work function is more negative. On a conventional energy level diagram, with the vacuum level at the top, a “higher” work function is illustrated as further away from the vacuum level in the downward direction. Thus, the definitions of HOMO and LUMO energy levels follow a different convention than work functions.

More details on OLEDs, and the definitions described above, can be found in U.S. Pat. No. 7,279,704, which is incorporated herein by reference in its entirety.

The performance of blue emitter PHOLED materials have been limited by the lifetime of the devices. To date, devices degrade too rapidly to be commercially viable. One limitation is thought to be the chemical stability of the blue phosphorescent material.

There is a need in the art for novel blue emitter PHOLED materials with improved properties, such as chemical stability. The present invention addresses this need in the art.

SUMMARY

According to an embodiment, a compound is provided that has a ligand L_(A) selected from the group consisting of Formula I and Formula II:

wherein ring A is a 5-membered or 6-membered carbocyclic or heterocyclic ring;

wherein Z is nitrogen or carbon;

wherein R¹ and R³ each represent from mono-substitution to the possible maximum number of substitution, or no substitution;

wherein Z¹, Z², Z³, and Z⁴ are each independently selected from the group consisting of N and CR;

wherein at least one of Z¹, Z², Z³, and Z⁴ is nitrogen;

wherein X is selected from the group consisting of O, S, and Se;

wherein each R, R¹ R², and R³ are independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof;

wherein any adjacent substituents of R, R¹ R², and R³ are optionally joined or fused into a ring;

wherein the ligand L_(A) is coordinated to a metal M; and

wherein the ligand L_(A) is optionally linked with other ligands to comprise a tridentate, tetradentate, pentadentate or hexadentate ligand.

According to another embodiment, an organic light emitting diode/device (OLED) is also provided. The OLED can include an anode, a cathode, and an organic layer, disposed between the anode and the cathode. The organic layer can include a compound that has a ligand L_(A) selected from the group consisting of Formula I and Formula II. According to yet another embodiment, the organic light emitting device is incorporated into a device selected from a consumer product, an electronic component module, and/or a lighting panel.

According to another embodiment, the invention provides a formulation comprising a compound that has a ligand L_(A) selected from the group consisting of Formula I and Formula II.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows an organic light emitting device.

FIG. 2 shows an inverted organic light emitting device that does not have a separate electron transport layer.

DETAILED DESCRIPTION

Generally, an OLED comprises at least one organic layer disposed between and electrically connected to an anode and a cathode. When a current is applied, the anode injects holes and the cathode injects electrons into the organic layer(s). The injected holes and electrons each migrate toward the oppositely charged electrode. When an electron and hole localize on the same molecule, an “exciton,” which is a localized electron-hole pair having an excited energy state, is formed. Light is emitted when the exciton relaxes via a photoemissive mechanism. In some cases, the exciton may be localized on an excimer or an exciplex. Non-radiative mechanisms, such as thermal relaxation, may also occur, but are generally considered undesirable.

The initial OLEDs used emissive molecules that emitted light from their singlet states (“fluorescence”) as disclosed, for example, in U.S. Pat. No. 4,769,292, which is incorporated by reference in its entirety. Fluorescent emission generally occurs in a time frame of less than 10 nanoseconds.

More recently, OLEDs having emissive materials that emit light from triplet states (“phosphorescence”) have been demonstrated. Baldo et al., “Highly Efficient Phosphorescent Emission from Organic Electroluminescent Devices,” Nature, vol. 395, 151-154, 1998; (“Baldo-I”) and Baldo et al., “Very high-efficiency green organic light-emitting devices based on electrophosphorescence,” Appl. Phys. Lett., vol. 75, No. 3, 4-6 (1999) (“Baldo-II”), are incorporated by reference in their entireties. Phosphorescence is described in more detail in U.S. Pat. No. 7,279,704 at cols. 5-6, which are incorporated by reference.

FIG. 1 shows an organic light emitting device 100. The figures are not necessarily drawn to scale. Device 100 may include a substrate 110, an anode 115, a hole injection layer 120, a hole transport layer 125, an electron blocking layer 130, an emissive layer 135, a hole blocking layer 140, an electron transport layer 145, an electron injection layer 150, a protective layer 155, a cathode 160, and a barrier layer 170. Cathode 160 is a compound cathode having a first conductive layer 162 and a second conductive layer 164. Device 100 may be fabricated by depositing the layers described, in order. The properties and functions of these various layers, as well as example materials, are described in more detail in U.S. Pat. No. 7,279,704 at cols. 6-10, which are incorporated by reference.

More examples for each of these layers are available. For example, a flexible and transparent substrate-anode combination is disclosed in U.S. Pat. No. 5,844,363, which is incorporated by reference in its entirety. An example of a p-doped hole transport layer is m-MTDATA doped with F₄-TCNQ at a molar ratio of 50:1, as disclosed in U.S. Patent Application Publication No. 2003/0230980, which is incorporated by reference in its entirety. Examples of emissive and host materials are disclosed in U.S. Pat. No. 6,303,238 to Thompson et al., which is incorporated by reference in its entirety. An example of an n-doped electron transport layer is BPhen doped with Li at a molar ratio of 1:1, as disclosed in U.S. Patent Application Publication No. 2003/0230980, which is incorporated by reference in its entirety. U.S. Pat. Nos. 5,703,436 and 5,707,745, which are incorporated by reference in their entireties, disclose examples of cathodes including compound cathodes having a thin layer of metal such as Mg:Ag with an overlying transparent, electrically-conductive, sputter-deposited ITO layer. The theory and use of blocking layers is described in more detail in U.S. Pat. No. 6,097,147 and U.S. Patent Application Publication No. 2003/0230980, which are incorporated by reference in their entireties. Examples of injection layers are provided in U.S. Patent Application Publication No. 2004/0174116, which is incorporated by reference in its entirety. A description of protective layers may be found in U.S. Patent Application Publication No. 2004/0174116, which is incorporated by reference in its entirety.

FIG. 2 shows an inverted OLED 200. The device includes a substrate 210, a cathode 215, an emissive layer 220, a hole transport layer 225, and an anode 230. Device 200 may be fabricated by depositing the layers described, in order. Because the most common OLED configuration has a cathode disposed over the anode, and device 200 has cathode 215 disposed under anode 230, device 200 may be referred to as an “inverted” OLED. Materials similar to those described with respect to device 100 may be used in the corresponding layers of device 200. FIG. 2 provides one example of how some layers may be omitted from the structure of device 100.

The simple layered structure illustrated in FIGS. 1 and 2 is provided by way of non-limiting example, and it is understood that embodiments of the invention may be used in connection with a wide variety of other structures. The specific materials and structures described are exemplary in nature, and other materials and structures may be used. Functional OLEDs may be achieved by combining the various layers described in different ways, or layers may be omitted entirely, based on design, performance, and cost factors. Other layers not specifically described may also be included. Materials other than those specifically described may be used. Although many of the examples provided herein describe various layers as comprising a single material, it is understood that combinations of materials, such as a mixture of host and dopant, or more generally a mixture, may be used. Also, the layers may have various sublayers. The names given to the various layers herein are not intended to be strictly limiting. For example, in device 200, hole transport layer 225 transports holes and injects holes into emissive layer 220, and may be described as a hole transport layer or a hole injection layer. In one embodiment, an OLED may be described as having an “organic layer” disposed between a cathode and an anode. This organic layer may comprise a single layer, or may further comprise multiple layers of different organic materials as described, for example, with respect to FIGS. 1 and 2.

Structures and materials not specifically described may also be used, such as OLEDs comprised of polymeric materials (PLEDs) such as disclosed in U.S. Pat. No. 5,247,190 to Friend et al., which is incorporated by reference in its entirety. By way of further example, OLEDs having a single organic layer may be used. OLEDs may be stacked, for example as described in U.S. Pat. No. 5,707,745 to Forrest et al, which is incorporated by reference in its entirety. The OLED structure may deviate from the simple layered structure illustrated in FIGS. 1 and 2. For example, the substrate may include an angled reflective surface to improve out-coupling, such as a mesa structure as described in U.S. Pat. No. 6,091,195 to Forrest et al., and/or a pit structure as described in U.S. Pat. No. 5,834,893 to Bulovic et al., which are incorporated by reference in their entireties.

Unless otherwise specified, any of the layers of the various embodiments may be deposited by any suitable method. For the organic layers, preferred methods include thermal evaporation, ink-jet, such as described in U.S. Pat. Nos. 6,013,982 and 6,087,196, which are incorporated by reference in their entireties, organic vapor phase deposition (OVPD), such as described in U.S. Pat. No. 6,337,102 to Forrest et al., which is incorporated by reference in its entirety, and deposition by organic vapor jet printing (OVJP), such as described in U.S. Pat. No. 7,431,968, which is incorporated by reference in its entirety. Other suitable deposition methods include spin coating and other solution based processes. Solution based processes are preferably carried out in nitrogen or an inert atmosphere. For the other layers, preferred methods include thermal evaporation. Preferred patterning methods include deposition through a mask, cold welding such as described in U.S. Pat. Nos. 6,294,398 and 6,468,819, which are incorporated by reference in their entireties, and patterning associated with some of the deposition methods such as ink-jet and OVID. Other methods may also be used. The materials to be deposited may be modified to make them compatible with a particular deposition method. For example, substituents such as alkyl and aryl groups, branched or unbranched, and preferably containing at least 3 carbons, may be used in small molecules to enhance their ability to undergo solution processing. Substituents having 20 carbons or more may be used, and 3-20 carbons is a preferred range. Materials with asymmetric structures may have better solution processibility than those having symmetric structures, because asymmetric materials may have a lower tendency to recrystallize Dendrimer substituents may be used to enhance the ability of small molecules to undergo solution processing.

Devices fabricated in accordance with embodiments of the present invention may further optionally comprise a barrier layer. One purpose of the barrier layer is to protect the electrodes and organic layers from damaging exposure to harmful species in the environment including moisture, vapor and/or gases, etc. The barrier layer may be deposited over, under or next to a substrate, an electrode, or over any other parts of a device including an edge. The barrier layer may comprise a single layer, or multiple layers. The barrier layer may be formed by various known chemical vapor deposition techniques and may include compositions having a single phase as well as compositions having multiple phases. Any suitable material or combination of materials may be used for the barrier layer. The barrier layer may incorporate an inorganic or an organic compound or both. The preferred barrier layer comprises a mixture of a polymeric material and a non-polymeric material as described in U.S. Pat. No. 7,968,146, PCT Pat. Application Nos. PCT/US2007/023098 and PCT/US2009/042829, which are herein incorporated by reference in their entireties. To be considered a “mixture”, the aforesaid polymeric and non-polymeric materials comprising the barrier layer should be deposited under the same reaction conditions and/or at the same time. The weight ratio of polymeric to non-polymeric material may be in the range of 95:5 to 5:95. The polymeric material and the non-polymeric material may be created from the same precursor material. In one example, the mixture of a polymeric material and a non-polymeric material consists essentially of polymeric silicon and inorganic silicon.

Devices fabricated in accordance with embodiments of the invention can be incorporated into a wide variety of electronic component modules (or units) that can be incorporated into a variety of electronic products or intermediate components. Examples of such electronic products or intermediate components include display screens, lighting devices such as discrete light source devices or lighting panels, etc. that can be utilized by the end-user product manufacturers. Such electronic component modules can optionally include the driving electronics and/or power source(s). Devices fabricated in accordance with embodiments of the invention can be incorporated into a wide variety of consumer products that have one or more of the electronic component modules (or units) incorporated therein. Such consumer products would include any kind of products that include one or more light source(s) and/or one or more of some type of visual displays. Some examples of such consumer products include flat panel displays, computer monitors, medical monitors, televisions, billboards, lights for interior or exterior illumination and/or signaling, heads-up displays, fully or partially transparent displays, flexible displays, laser printers, telephones, cell phones, tablets, phablets, personal digital assistants (PDAs), wearable device, laptop computers, digital cameras, camcorders, viewfinders, micro-displays, 3-D displays, virtual reality or augmented reality displays, vehicles, a large area wall, theater or stadium screen, or a sign. Various control mechanisms may be used to control devices fabricated in accordance with the present invention, including passive matrix and active matrix. Many of the devices are intended for use in a temperature range comfortable to humans, such as 18 degrees C. to 30 degrees C., and more preferably at room temperature (20-25 degrees C.), but could be used outside this temperature range, for example, from −40 degree C. to +80 degree C.

The materials and structures described herein may have applications in devices other than OLEDs. For example, other optoelectronic devices such as organic solar cells and organic photodetectors may employ the materials and structures. More generally, organic devices, such as organic transistors, may employ the materials and structures.

The term “halo,” “halogen,” or “halide” as used herein includes fluorine, chlorine, bromine, and iodine.

The term “alkyl” as used herein contemplates both straight and branched chain alkyl radicals. Preferred alkyl groups are those containing from one to fifteen carbon atoms and includes methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 2,2-dimethylpropyl, and the like. Additionally, the alkyl group may be optionally substituted.

The term “cycloalkyl” as used herein contemplates cyclic alkyl radicals. Preferred cycloalkyl groups are those containing 3 to 10 ring carbon atoms and includes cyclopropyl, cyclopentyl, cyclohexyl, adamantyl, and the like. Additionally, the cycloalkyl group may be optionally substituted.

The term “alkenyl” as used herein contemplates both straight and branched chain alkene radicals. Preferred alkenyl groups are those containing two to fifteen carbon atoms. Additionally, the alkenyl group may be optionally substituted.

The term “alkynyl” as used herein contemplates both straight and branched chain alkyne radicals. Preferred alkynyl groups are those containing two to fifteen carbon atoms. Additionally, the alkynyl group may be optionally substituted.

The terms “aralkyl” or “arylalkyl” as used herein are used interchangeably and contemplate an alkyl group that has as a substituent an aromatic group. Additionally, the aralkyl group may be optionally substituted.

The term “heterocyclic group” as used herein contemplates aromatic and non-aromatic cyclic radicals. Hetero-aromatic cyclic radicals also means heteroaryl. Preferred hetero-non-aromatic cyclic groups are those containing 3 to 7 ring atoms which includes at least one hetero atom, and includes cyclic amines such as morpholino, piperdino, pyrrolidino, and the like, and cyclic ethers, such as tetrahydrofuran, tetrahydropyran, and the like. Additionally, the heterocyclic group may be optionally substituted.

The term “aryl” or “aromatic group” as used herein contemplates single-ring groups and polycyclic ring systems. The polycyclic rings may have two or more rings in which two carbons are common to two adjoining rings (the rings are “fused”) wherein at least one of the rings is aromatic, e.g., the other rings can be cycloalkyls, cycloalkenyls, aryl, heterocycles, and/or heteroaryls. Preferred aryl groups are those containing six to thirty carbon atoms, preferably six to twenty carbon atoms, more preferably six to twelve carbon atoms. Especially preferred is an aryl group having six carbons, ten carbons or twelve carbons. Suitable aryl groups include phenyl, biphenyl, triphenyl, triphenylene, tetraphenylene, naphthalene, anthracene, phenalene, phenanthrene, fluorene, pyrene, chrysene, perylene, and azulene, preferably phenyl, biphenyl, triphenyl, triphenylene, fluorene, and naphthalene. Additionally, the aryl group may be optionally substituted.

The term “heteroaryl” as used herein contemplates single-ring hetero-aromatic groups that may include from one to five heteroatoms. The term heteroaryl also includes polycyclic hetero-aromatic systems having two or more rings in which two atoms are common to two adjoining rings (the rings are “fused”) wherein at least one of the rings is a heteroaryl, e.g., the other rings can be cycloalkyls, cycloalkenyls, aryl, heterocycles, and/or heteroaryls. Preferred heteroaryl groups are those containing three to thirty carbon atoms, preferably three to twenty carbon atoms, more preferably three to twelve carbon atoms. Suitable heteroaryl groups include dibenzothiophene, dibenzofuran, dibenzoselenophene, furan, thiophene, benzofuran, benzothiophene, benzoselenophene, carbazole, indolocarbazole, pyridylindole, pyrrolodipyridine, pyrazole, imidazole, triazole, oxazole, thiazole, oxadiazole, oxatriazole, dioxazole, thiadiazole, pyridine, pyridazine, pyrimidine, pyrazine, triazine, oxazine, oxathiazine, oxadiazine, indole, benzimidazole, indazole, indoxazine, benzoxazole, benzisoxazole, benzothiazole, quinoline, isoquinoline, cinnoline, quinazoline, quinoxaline, naphthyridine, phthalazine, pteridine, xanthene, acridine, phenazine, phenothiazine, phenoxazine, benzofuropyridine, furodipyridine, benzothienopyridine, thienodipyridine, benzoselenophenopyridine, and selenophenodipyridine, preferably dibenzothiophene, dibenzofuran, dibenzoselenophene, carbazole, indolocarbazole, imidazole, pyridine, triazine, benzimidazole, 1,2-azaborine, 1,3-azaborine, 1,4-azaborine, borazine, and aza-analogs thereof. Additionally, the heteroaryl group may be optionally substituted.

The alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, heterocyclic group, aryl, and heteroaryl may be unsubstituted or may be substituted with one or more substituents selected from the group consisting of deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, cyclic amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acid, ether, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof.

As used herein, “substituted” indicates that a substituent other than H is bonded to the relevant position, such as carbon. Thus, for example, where R¹ is mono-substituted, then one R¹ must be other than H. Similarly, where R¹ is di-substituted, then two of R¹ must be other than H. Similarly, where R¹ is unsubstituted, R¹ is hydrogen for all available positions.

The “aza” designation in the fragments described herein, i.e. aza-dibenzofuran, aza-dibenzothiophene, etc. means that one or more of the C—H groups in the respective fragment can be replaced by a nitrogen atom, for example, and without any limitation, azatriphenylene encompasses both dibenzo[f,h]quinoxaline and dibenzo[f,h]quinoline. One of ordinary skill in the art can readily envision other nitrogen analogs of the aza-derivatives described above, and all such analogs are intended to be encompassed by the terms as set forth herein.

It is to be understood that when a molecular fragment is described as being a substituent or otherwise attached to another moiety, its name may be written as if it were a fragment (e.g. phenyl, phenylene, naphthyl, dibenzofuryl) or as if it were the whole molecule (e.g. benzene, naphthalene, dibenzofuran). As used herein, these different ways of designating a substituent or attached fragment are considered to be equivalent.

The performance of blue emitter PHOLED materials have been limited by the lifetime of the devices. To date, devices degrade too rapidly to be commercially viable. One limitation is thought to be the chemical stability of the blue phosphorescent material. In one aspect, the present invention relates to the development of new phosphorescent materials with appropriate color and chemical stability.

Compounds of the Invention

In one aspect, the invention includes a compound comprising a ligand L_(A) selected from the group consisting of Formula I and Formula II:

wherein ring A is a 5-membered or 6-membered carbocyclic or heterocyclic ring;

wherein Z is nitrogen or carbon;

wherein R¹ and R³ each represent from mono-substitution to the possible maximum number of substitution, or no substitution;

wherein Z¹, Z², Z³, and Z₄ are each independently selected from the group consisting of N and CR;

wherein at least one of Z¹, Z², Z³, and Z₄ is nitrogen;

wherein X is selected from the group consisting of O, S, and Se;

wherein each R, R¹ R², and R³ are independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof;

wherein any adjacent substituents of R, R¹ R², and R³ are optionally joined or fused into a ring;

wherein the ligand L_(A) is coordinated to a metal M; and

wherein the ligand L_(A) is optionally linked with other ligands to comprise a tridentate, tetradentate, pentadentate or hexadentate ligand.

Any 5-membered or 6-membered carbocyclic or heterocyclic ring is contemplated for A, as would be understood by one of ordinary skill in the art. In one embodiment, A is selected from the group consisting of pyridine, imidazole, isoimidazole, and pyrazole.

Any metal M is contemplated by the present invention, as would be understood by one of ordinary skill in the art. In one embodiment, M is selected from the group consisting of Ir, Rh, Re, Ru, Os, Pt, Au, and Cu. In another embodiment, M is Ir or Pt.

In one embodiment, the compound is homoleptic. In another embodiment, the compound is heteroleptic.

In one embodiment, X is O. In another embodiment, X is S.

In one embodiment, one of Z¹, Z², Z³, and Z⁴ is nitrogen, and three of Z¹, Z², Z³, and Z⁴ is CR.

In one embodiment, ligand L_(A) is selected from the group consisting of:

In one embodiment, ligand L_(A) is selected from the group consisting of:

LA1 to LA318 based on the chemical structure:

LA # R11 R12 R13 R14 R31 R32 R33 1 CD3 CD3 H H H H H 2 CD3 CH3 H H H H H 3 CD3 H 2,6DIP H H H H 4 CD3 H 2,6DMB H H H H 5 CD3 H CD3 H H H H 6 CD3 H CH3 H H H H 7 CD3 H H 2,6DIP H H H 8 CD3 H H 2,6DMB H H H 9 CD3 H H CD3 H H H 10 CD3 H H CH3 H H H 11 CD3 H H H 2,6DIP H H 12 CD3 H H H 2,6DMB H H 13 CD3 H H H CD3 H H 14 CD3 H H H CH3 H H 15 CD3 H H H H 2,6DIP H 16 CD3 H H H H 2,6DMB H 17 CD3 H H H H CD3 H 18 CD3 H H H H CH3 H 19 CD3 H H H H H 2,6DIP 20 CD3 H H H H H 2,6DMB 21 CD3 H H H H H CD3 22 CD3 H H H H H CH3 23 CD3 H H H H H H 24 CD3 H H H H H i-Pr 25 CD3 H H H H i-Pr H 26 CD3 H H H i-Pr H H 27 CD3 H H i-Pr H H H 28 CD3 H i-Pr H H H H 29 CD3 i-Pr H H H H H 30 CH3 CD3 H H H H H 31 CH3 CH3 H H H H H 32 CH3 H 2,6DIP H H H H 33 CH3 H 2,6DMB H H H H 34 CH3 H CD3 H H H H 35 CH3 H CH3 H H H H 36 CH3 H H 2,6DIP H H H 37 CH3 H H 2,6DMB H H H 38 CH3 H H CD3 H H H 39 CH3 H H CH3 H H H 40 CH3 H H H 2,6DIP H H 41 CH3 H H H 2,6DMB H H 42 CH3 H H H CD3 H H 43 CH3 H H H CH3 H H 44 CH3 H H H H 2,6DIP H 45 CH3 H H H H 2,6DMB H 46 CH3 H H H H CD3 H 47 CH3 H H H H CH3 H 48 CH3 H H H H H 2,6DIP 49 CH3 H H H H H 2,6DMB 50 CH3 H H H H H CD3 51 CH3 H H H H H CH3 52 CH3 H H H H H H 53 CH3 H H H H H i-Pr 54 CH3 H H H H i-Pr H 55 CH3 H H H i-Pr H H 56 CH3 H H i-Pr H H H 57 CH3 H i-Pr H H H H 58 CH3 i-Pr H H H H H 59 H 2,6DIP H CD3 H H H 60 H 2,6DIP H CH3 H H H 61 H 2,6DIP H H CD3 H H 62 H 2,6DIP H H CH3 H H 63 H 2,6DIP H H H CD3 H 64 H 2,6DIP H H H CH3 H 65 H 2,6DIP H H H H CD3 66 H 2,6DIP H H H H CH3 67 H 2,6DIP H H H H H 68 H 2,6DMB H CD3 H H H 69 H 2,6DMB H CH3 H H H 70 H 2,6DMB H H CD3 H H 71 H 2,6DMB H H CH3 H H 72 H 2,6DMB H H H CD3 H 73 H 2,6DMB H H H CH3 H 74 H 2,6DMB H H H H CD3 75 H 2,6DMB H H H H CH3 76 H 2,6DMB H H H H H 77 H CD3 CD3 H H H H 78 H CD3 CH3 H H H H 79 H CD3 H 2,6DIP H H H 80 H CD3 H 2,6DMB H H H 81 H CD3 H CD3 H H H 82 H CD3 H CH3 H H H 83 H CD3 H H 2,6DIP H H 84 H CD3 H H 2,6DMB H H 85 H CD3 H H CD3 H H 86 H CD3 H H CH3 H H 87 H CD3 H H H 2,6DIP H 88 H CD3 H H H 2,6DMB H 89 H CD3 H H H CD3 H 90 H CD3 H H H CH3 H 91 H CD3 H H H H 2,6DIP 92 H CD3 H H H H 2,6DMB 93 H CD3 H H H H CD3 94 H CD3 H H H H CH3 95 H CD3 H H H H H 96 H CD3 H H H H i-Pr 97 H CD3 H H H i-Pr H 98 H CD3 H H i-Pr H H 99 H CD3 H i-Pr H H H 100 H CD3 i-Pr H H H H 101 H CH3 CD3 H H H H 102 H CH3 CH3 H H H H 103 H CH3 H 2,6DIP H H H 104 H CH3 H 2,6DMB H H H 105 H CH3 H CD3 H H H 106 H CH3 H CH3 H H H 107 H CH3 H H 2,6DIP H H 108 H CH3 H H 2,6DMB H H 109 H CH3 H H CD3 H H 110 H CH3 H H CH3 H H 111 H CH3 H H H 2,6DIP H 112 H CH3 H H H 2,6DMB H 113 H CH3 H H H CD3 H 114 H CH3 H H H CH3 H 115 H CH3 H H H H 2,6DIP 116 H CH3 H H H H 2,6DMB 117 H CH3 H H H H CD3 118 H CH3 H H H H CH3 119 H CH3 H H H H H 120 H CH3 H H H H i-Pr 121 H CH3 H H H i-Pr H 122 H CH3 H H i-Pr H H 123 H CH3 H i-Pr H H H 124 H CH3 i-Pr H H H H 125 H H 2,6DIP H CD3 H H 126 H H 2,6DIP H CH3 H H 127 H H 2,6DIP H H CD3 H 128 H H 2,6DIP H H CH3 H 129 H H 2,6DIP H H H CD3 130 H H 2,6DIP H H H CH3 131 H H 2,6DIP H H H H 132 H H 2,6DMB H CD3 H H 133 H H 2,6DMB H CH3 H H 134 H H 2,6DMB H H CD3 H 135 H H 2,6DMB H H CH3 H 136 H H 2,6DMB H H H CD3 137 H H 2,6DMB H H H CH3 138 H H 2,6DMB H H H H 139 H H CD3 CD3 H H H 140 H H CD3 CH3 H H H 141 H H CD3 H 2,6DIP H H 142 H H CD3 H 2,6DMB H H 143 H H CD3 H CD3 H H 144 H H CD3 H CH3 H H 145 H H CD3 H H 2,6DIP H 146 H H CD3 H H 2,6DMB H 147 H H CD3 H H CD3 H 148 H H CD3 H H CH3 H 149 H H CD3 H H H 2,6DIP 150 H H CD3 H H H 2,6DMB 151 H H CD3 H H H CD3 152 H H CD3 H H H CH3 153 H H CD3 H H H H 154 H H CD3 H H H i-Pr 155 H H CD3 H H i-Pr H 156 H H CD3 H i-Pr H H 157 H H CD3 i-Pr H H H 158 H H CH3 CD3 H H H 159 H H CH3 CH3 H H H 160 H H CH3 H 2,6DIP H H 161 H H CH3 H 2,6DMB H H 162 H H CH3 H CD3 H H 163 H H CH3 H CH3 H H 164 H H CH3 H H 2,6DIP H 165 H H CH3 H H 2,6DMB H 166 H H CH3 H H CD3 H 167 H H CH3 H H CH3 H 168 H H CH3 H H H 2,6DIP 169 H H CH3 H H H 2,6DMB 170 H H CH3 H H H CD3 171 H H CH3 H H H CH3 172 H H CH3 H H H H 173 H H CH3 H H H i-Pr 174 H H CH3 H H i-Pr H 175 H H CH3 H i-Pr H H 176 H H CH3 i-Pr H H H 177 H H H 2,6DIP CD3 H H 178 H H H 2,6DIP CH3 H H 179 H H H 2,6DIP H CD3 H 180 H H H 2,6DIP H CH3 H 181 H H H 2,6DIP H H CD3 182 H H H 2,6DIP H H CH3 183 H H H 2,6DIP H H H 184 H H H 2,6DMB CD3 H H 185 H H H 2,6DMB CH3 H H 186 H H H 2,6DMB H CD3 H 187 H H H 2,6DMB H CH3 H 188 H H H 2,6DMB H H CD3 189 H H H 2,6DMB H H CH3 190 H H H 2,6DMB H H H 191 H H H CD3 2,6DIP H H 192 H H H CD3 2,6DMB H H 193 H H H CD3 CD3 H H 194 H H H CD3 CH3 H H 195 H H H CD3 H 2,6DIP H 196 H H H CD3 H 2,6DMB H 197 H H H CD3 H CD3 H 198 H H H CD3 H CH3 H 199 H H H CD3 H H 2,6DIP 200 H H H CD3 H H 2,6DMB 201 H H H CD3 H H CD3 202 H H H CD3 H H CH3 203 H H H CD3 H H H 204 H H H CD3 H H i-Pr 205 H H H CD3 H i-Pr H 206 H H H CD3 i-Pr H H 207 H H H CH3 2,6DIP H H 208 H H H CH3 2,6DMB H H 209 H H H CH3 CD3 H H 210 H H H CH3 CH3 H H 211 H H H CH3 H 2,6DIP H 212 H H H CH3 H 2,6DMB H 213 H H H CH3 H CD3 H 214 H H H CH3 H CH3 H 215 H H H CH3 H H 2,6DIP 216 H H H CH3 H H 2,6DMB 217 H H H CH3 H H CD3 218 H H H CH3 H H CH3 219 H H H CH3 H H H 220 H H H CH3 H H i-Pr 221 H H H CH3 H i-Pr H 222 H H H CH3 i-Pr H H 223 H H H H 2,6DIP H CD3 224 H H H H 2,6DIP H CH3 225 H H H H 2,6DIP H H 226 H H H H 2,6DMB H CD3 227 H H H H 2,6DMB H CH3 228 H H H H 2,6DMB H H 229 H H H H CD3 CD3 H 230 H H H H CD3 CH3 H 231 H H H H CD3 H 2,6DIP 232 H H H H CD3 H 2,6DMB 233 H H H H CD3 H CD3 234 H H H H CD3 H CH3 235 H H H H CD3 H H 236 H H H H CD3 H i-Pr 237 H H H H CD3 i-Pr H 238 H H H H CH3 CD3 H 239 H H H H CH3 CH3 H 240 H H H H CH3 H 2,6DIP 241 H H H H CH3 H 2,6DMB 242 H H H H CH3 H CD3 243 H H H H CH3 H CH3 244 H H H H CH3 H H 245 H H H H CH3 H i-Pr 246 H H H H CH3 i-Pr H 247 H H H H H 2,6DIP CD3 248 H H H H H 2,6DIP CH3 249 H H H H H 2,6DIP H 250 H H H H H 2,6DMB CD3 251 H H H H H 2,6DMB CH3 252 H H H H H 2,6DMB H 253 H H H H H CD3 2,6DIP 254 H H H H H CD3 2,6DMB 255 H H H H H CD3 CD3 256 H H H H H CD3 CH3 257 H H H H H CD3 H 258 H H H H H CD3 i-Pr 259 H H H H H CH3 2,6DIP 260 H H H H H CH3 2,6DMB 261 H H H H H CH3 CD3 262 H H H H H CH3 CH3 263 H H H H H CH3 H 264 H H H H H CH3 i-Pr 265 H H H H H H 2,6DIP 266 H H H H H H 2,6DMB 267 H H H H H H CD3 268 H H H H H H CH3 269 H H H H H H H 270 H H H H H H i-Pr 271 H H H H H i-Pr CD3 272 H H H H H i-Pr CH3 273 H H H H H i-Pr H 274 H H H H i-Pr CD3 H 275 H H H H i-Pr CH3 H 276 H H H H i-Pr H CD3 277 H H H H i-Pr H CH3 278 H H H H i-Pr H H 279 H H H i-Pr CD3 H H 280 H H H i-Pr CH3 H H 281 H H H i-Pr H CD3 H 282 H H H i-Pr H CH3 H 283 H H H i-Pr H H CD3 284 H H H i-Pr H H CH3 285 H H H i-Pr H H H 286 H H i-Pr CD3 H H H 287 H H i-Pr CH3 H H H 288 H H i-Pr H CD3 H H 289 H H i-Pr H CH3 H H 290 H H i-Pr H H CD3 H 291 H H i-Pr H H CH3 H 292 H H i-Pr H H H CD3 293 H H i-Pr H H H CH3 294 H H i-Pr H H H H 295 H i-Pr CD3 H H H H 296 H i-Pr CH3 H H H H 297 H i-Pr H CD3 H H H 298 H i-Pr H CH3 H H H 299 H i-Pr H H CD3 H H 300 H i-Pr H H CH3 H H 301 H i-Pr H H H CD3 H 302 H i-Pr H H H CH3 H 303 H i-Pr H H H H CD3 304 H i-Pr H H H H CH3 305 H i-Pr H H H H H 306 i-Pr CD3 H H H H H 307 i-Pr CH3 H H H H H 308 i-Pr H CD3 H H H H 309 i-Pr H CH3 H H H H 310 i-Pr H H CD3 H H H 311 i-Pr H H CH3 H H H 312 i-Pr H H H CD3 H H 313 i-Pr H H H CH3 H H 314 i-Pr H H H H CD3 H 315 i-Pr H H H H CH3 H 316 i-Pr H H H H H CD3 317 i-Pr H H H H H CH3 318 i-Pr H H H H H H LA319 to LA628 based on the structure:

LA # R11 R12 R13 R14 R31 R32 R34 319 CD3 CD3 H H H H H 320 CD3 CH3 H H H H H 321 CD3 H 2,6DIP H H H H 322 CD3 H 2,6DMB H H H H 323 CD3 H CD3 H H H H 324 CD3 H CH3 H H H H 325 CD3 H H 2,6DIP H H H 326 CD3 H H 2,6DMB H H H 327 CD3 H H CD3 H H H 328 CD3 H H CH3 H H H 329 CD3 H H H 2,6DIP H H 330 CD3 H H H 2,6DMB H H 331 CD3 H H H CD3 H H 332 CD3 H H H CH3 H H 333 CD3 H H H H 2,6DIP H 334 CD3 H H H H 2,6DMB H 335 CD3 H H H H CD3 H 336 CD3 H H H H CH3 H 337 CD3 H H H H H 2,6DIP 338 CD3 H H H H H 2,6DMB 339 CD3 H H H H H CD3 340 CD3 H H H H H CH3 341 CD3 H H H H H H 342 CD3 H H H H H i-Pr 343 CD3 H H H H i-Pr H 344 CD3 H H H i-Pr H H 345 CD3 H H i-Pr H H H 346 CD3 H i-Pr H H H H 347 CD3 i-Pr H H H H H 348 CH3 CD3 H H H H H 349 CH3 CH3 H H H H H 350 CH3 H 2,6DIP H H H H 351 CH3 H 2,6DMB H H H H 352 CH3 H CD3 H H H H 353 CH3 H CH3 H H H H 354 CH3 H H 2,6DIP H H H 355 CH3 H H 2,6DMB H H H 356 CH3 H H CD3 H H H 357 CH3 H H CH3 H H H 358 CH3 H H H 2,6DIP H H 359 CH3 H H H 2,6DMB H H 360 CH3 H H H CD3 H H 361 CH3 H H H CH3 H H 362 CH3 H H H H 2,6DIP H 363 CH3 H H H H 2,6DMB H 364 CH3 H H H H CD3 H 365 CH3 H H H H CH3 H 366 CH3 H H H H H 2,6DIP 367 CH3 H H H H H 2,6DMB 368 CH3 H H H H H CD3 369 CH3 H H H H H CH3 370 CH3 H H H H H H 371 CH3 H H H H H i-Pr 372 CH3 H H H H i-Pr H 373 CH3 H H H i-Pr H H 374 CH3 H H i-Pr H H H 375 CH3 H i-Pr H H H H 376 CH3 i-Pr H H H H H 377 H 2,6DIP H CD3 H H H 378 H 2,6DIP H CH3 H H H 379 H 2,6DIP H H CD3 H H 380 H 2,6DIP H H CH3 H H 381 H 2,6DIP H H H CD3 H 382 H 2,6DIP H H H CH3 H 383 H 2,6DIP H H H H CD3 384 H 2,6DIP H H H H CH3 385 H 2,6DIP H H H H H 386 H 2,6DMB H CD3 H H H 387 H 2,6DMB H CH3 H H H 388 H 2,6DMB H H CD3 H H 389 H 2,6DMB H H CH3 H H 390 H 2,6DMB H H H CD3 H 391 H 2,6DMB H H H CH3 H 392 H 2,6DMB H H H H CD3 393 H 2,6DMB H H H H CH3 394 H 2,6DMB H H H H H 395 H CD3 CD3 H H H H 396 H CD3 CH3 H H H H 397 H CD3 H 2,6DIP H H H 398 H CD3 H 2,6DMB H H H 399 H CD3 H CD3 H H H 400 H CD3 H CH3 H H H 401 H CD3 H H 2,6DIP H H 402 H CD3 H H 2,6DMB H H 403 H CD3 H H CD3 H H 404 H CD3 H H CH3 H H 405 H CD3 H H H 2,6DIP H 406 H CD3 H H H 2,6DMB H 407 H CD3 H H H CD3 H 408 H CD3 H H H CH3 H 409 H CD3 H H H H 2,6DIP 410 H CD3 H H H H 2,6DMB 411 H CD3 H H H H CD3 412 H CD3 H H H H CH3 413 H CD3 H H H H H 414 H CD3 H H H H i-Pr 415 H CD3 H H H i-Pr H 416 H CD3 H H i-Pr H H 417 H CD3 H i-Pr H H H 418 H CD3 i-Pr H H H H 419 H CH3 CD3 H H H H 420 H CH3 CH3 H H H H 421 H CH3 H 2,6DIP H H H 422 H CH3 H 2,6DMB H H H 423 H CH3 H CD3 H H H 424 H CH3 H CH3 H H H 425 H CH3 H H 2,6DIP H H 426 H CH3 H H 2,6DMB H H 427 H CH3 H H CD3 H H 428 H CH3 H H CH3 H H 429 H CH3 H H H 2,6DIP H 430 H CH3 H H H 2,6DMB H 431 H CH3 H H H CD3 H 432 H CH3 H H H CH3 H 433 H CH3 H H H H 2,6DIP 434 H CH3 H H H H 2,6DMB 435 H CH3 H H H H CD3 436 H CH3 H H H H CH3 437 H CH3 H H H H H 438 H CH3 H H H H i-Pr 439 H CH3 H H H i-Pr H 440 H CH3 H H i-Pr H H 441 H CH3 H i-Pr H H H 442 H CH3 i-Pr H H H H 443 H H 2,6DIP H CD3 H H 444 H H 2,6DIP H CH3 H H 445 H H 2,6DIP H H CD3 H 446 H H 2,6DIP H H CH3 H 447 H H 2,6DIP H H H CD3 448 H H 2,6DIP H H H CH3 449 H H 2,6DIP H H H H 450 H H 2,6DMB H CD3 H H 451 H H 2,6DMB H CH3 H H 452 H H 2,6DMB H H CD3 H 453 H H 2,6DMB H H CH3 H 454 H H 2,6DMB H H H CD3 455 H H 2,6DMB H H H CH3 456 H H 2,6DMB H H H H 457 H H CD3 CD3 H H H 458 H H CD3 CH3 H H H 459 H H CD3 H 2,6DIP H H 460 H H CD3 H 2,6DMB H H 461 H H CD3 H CD3 H H 462 H H CD3 H CH3 H H 463 H H CD3 H H 2,6DIP H 464 H H CD3 H H 2,6DMB H 465 H H CD3 H H CD3 H 466 H H CD3 H H CH3 H 467 H H CD3 H H H 2,6DIP 468 H H CD3 H H H 2,6DMB 469 H H CD3 H H H CD3 470 H H CD3 H H H CH3 471 H H CD3 H H H H 472 H H CD3 H H H i-Pr 473 H H CD3 H H i-Pr H 474 H H CD3 H i-Pr H H 475 H H CD3 i-Pr H H H 476 H H CH3 CD3 H H H 477 H H CH3 CH3 H H H 478 H H CH3 H 2,6DIP H H 479 H H CH3 H 2,6DMB H H 480 H H CH3 H CD3 H H 481 H H CH3 H CH3 H H 482 H H CH3 H H 2,6DIP H 483 H H CH3 H H 2,6DMB H 484 H H CH3 H H CD3 H 485 H H CH3 H H CH3 H 486 H H CH3 H H H 2,6DIP 487 H H CH3 H H H 2,6DMB 488 H H CH3 H H H CD3 489 H H CH3 H H H CH3 490 H H CH3 H H H H 491 H H CH3 H H H i-Pr 492 H H CH3 H H i-Pr H 493 H H CH3 H i-Pr H H 494 H H CH3 i-Pr H H H 495 H H H 2,6DIP H CD3 H 496 H H H 2,6DIP H CH3 H 497 H H H 2,6DIP H H CD3 498 H H H 2,6DIP H H CH3 499 H H H 2,6DIP H H H 500 H H H 2,6DMB H CD3 H 501 H H H 2,6DMB H CH3 H 502 H H H 2,6DMB H H CD3 503 H H H 2,6DMB H H CH3 504 H H H 2,6DMB H H H 505 H H H CD3 CD3 H H 506 H H H CD3 CH3 H H 507 H H H CD3 H 2,6DIP H 508 H H H CD3 H 2,6DMB H 509 H H H CD3 H CD3 H 510 H H H CD3 H CH3 H 511 H H H CD3 H H 2,6DIP 512 H H H CD3 H H 2,6DMB 513 H H H CD3 H H CD3 514 H H H CD3 H H CH3 515 H H H CD3 H H H 516 H H H CD3 H H i-Pr 517 H H H CD3 H i-Pr H 518 H H H CD3 i-Pr H H 519 H H H CH3 CD3 H H 520 H H H CH3 CH3 H H 521 H H H CH3 H 2,6DIP H 522 H H H CH3 H 2,6DMB H 523 H H H CH3 H CD3 H 524 H H H CH3 H CH3 H 525 H H H CH3 H H 2,6DIP 526 H H H CH3 H H 2,6DMB 527 H H H CH3 H H CD3 528 H H H CH3 H H CH3 529 H H H CH3 H H H 530 H H H CH3 H H i-Pr 531 H H H CH3 H i-Pr H 532 H H H CH3 i-Pr H H 533 H H H H 2,6DIP H CD3 534 H H H H 2,6DIP H CH3 535 H H H H 2,6DIP H H 536 H H H H 2,6DMB H CD3 537 H H H H 2,6DMB H CH3 538 H H H H 2,6DMB H H 539 H H H H CD3 CD3 H 540 H H H H CD3 CH3 H 541 H H H H CD3 H 2,6DIP 542 H H H H CD3 H 2,6DMB 543 H H H H CD3 H CD3 544 H H H H CD3 H CH3 545 H H H H CD3 H H 546 H H H H CD3 H i-Pr 547 H H H H CD3 i-Pr H 548 H H H H CH3 CD3 H 549 H H H H CH3 CH3 H 550 H H H H CH3 H 2,6DIP 551 H H H H CH3 H 2,6DMB 552 H H H H CH3 H CD3 553 H H H H CH3 H CH3 554 H H H H CH3 H H 555 H H H H CH3 H i-Pr 556 H H H H CH3 i-Pr H 557 H H H H H 2,6DIP CD3 558 H H H H H 2,6DIP CH3 559 H H H H H 2,6DIP H 560 H H H H H 2,6DMB CD3 561 H H H H H 2,6DMB CH3 562 H H H H H 2,6DMB H 563 H H H H H CD3 2,6DIP 564 H H H H H CD3 2,6DMB 565 H H H H H CD3 CD3 566 H H H H H CD3 CH3 567 H H H H H CD3 H 568 H H H H H CD3 i-Pr 569 H H H H H CH3 2,6DIP 570 H H H H H CH3 2,6DMB 571 H H H H H CH3 CD3 572 H H H H H CH3 CH3 573 H H H H H CH3 H 574 H H H H H CH3 i-Pr 575 H H H H H H 2,6DIP 576 H H H H H H 2,6DMB 577 H H H H H H CD3 578 H H H H H H CH3 579 H H H H H H H 580 H H H H H H i-Pr 581 H H H H H i-Pr CD3 582 H H H H H i-Pr CH3 583 H H H H H i-Pr H 584 H H H H i-Pr CD3 H 585 H H H H i-Pr CH3 H 586 H H H H i-Pr H CD3 587 H H H H i-Pr H CH3 588 H H H H i-Pr H H 589 H H H i-Pr CD3 H H 590 H H H i-Pr CH3 H H 591 H H H i-Pr H CD3 H 592 H H H i-Pr H CH3 H 593 H H H i-Pr H H CD3 594 H H H i-Pr H H CH3 595 H H H i-Pr H H H 596 H H i-Pr CD3 H H H 597 H H i-Pr CH3 H H H 598 H H i-Pr H CD3 H H 599 H H i-Pr H CH3 H H 600 H H i-Pr H H CD3 H 601 H H i-Pr H H CH3 H 602 H H i-Pr H H H CD3 603 H H i-Pr H H H CH3 604 H H i-Pr H H H H 605 H i-Pr CD3 H H H H 606 H i-Pr CH3 H H H H 607 H i-Pr H CD3 H H H 608 H i-Pr H CH3 H H H 609 H i-Pr H H CD3 H H 610 H i-Pr H H CH3 H H 611 H i-Pr H H H CD3 H 612 H i-Pr H H H CH3 H 613 H i-Pr H H H H CD3 614 H i-Pr H H H H CH3 615 H i-Pr H H H H H 616 i-Pr CD3 H H H H H 617 i-Pr CH3 H H H H H 618 i-Pr H CD3 H H H H 619 i-Pr H CH3 H H H H 620 i-Pr H H CD3 H H H 621 i-Pr H H CH3 H H H 622 i-Pr H H H CD3 H H 623 i-Pr H H H CH3 H H 624 i-Pr H H H H CD3 H 625 i-Pr H H H H CH3 H 626 i-Pr H H H H H CD3 627 i-Pr H H H H H CH3 628 i-Pr H H H H H H LA629 to LA938 based on the structure:

LA # R11 R12 R13 R14 R31 R33 R34 629 CD3 CD3 H H H H H 630 CD3 CH3 H H H H H 631 CD3 H 2,6DIP H H H H 632 CD3 H 2,6DMB H H H H 633 CD3 H CD3 H H H H 634 CD3 H CH3 H H H H 635 CD3 H H 2,6DIP H H H 636 CD3 H H 2,6DMB H H H 637 CD3 H H CD3 H H H 638 CD3 H H CH3 H H H 639 CD3 H H H 2,6DIP H H 640 CD3 H H H 2,6DMB H H 641 CD3 H H H CD3 H H 642 CD3 H H H CH3 H H 643 CD3 H H H H 2,6DIP H 644 CD3 H H H H 2,6DMB H 645 CD3 H H H H CD3 H 646 CD3 H H H H CH3 H 647 CD3 H H H H H 2,6DIP 648 CD3 H H H H H 2,6DMB 649 CD3 H H H H H CD3 650 CD3 H H H H H CH3 651 CD3 H H H H H H 652 CD3 H H H H H i-Pr 653 CD3 H H H H i-Pr H 654 CD3 H H H i-Pr H H 655 CD3 H H i-Pr H H H 656 CD3 H i-Pr H H H H 657 CD3 i-Pr H H H H H 658 CH3 CD3 H H H H H 659 CH3 CH3 H H H H H 660 CH3 H 2,6DIP H H H H 661 CH3 H 2,6DMB H H H H 662 CH3 H CD3 H H H H 663 CH3 H CH3 H H H H 664 CH3 H H 2,6DIP H H H 665 CH3 H H 2,6DMB H H H 666 CH3 H H CD3 H H H 667 CH3 H H CH3 H H H 668 CH3 H H H 2,6DIP H H 669 CH3 H H H 2,6DMB H H 670 CH3 H H H CD3 H H 671 CH3 H H H CH3 H H 672 CH3 H H H H 2,6DIP H 673 CH3 H H H H 2,6DMB H 674 CH3 H H H H CD3 H 675 CH3 H H H H CH3 H 676 CH3 H H H H H 2,6DIP 677 CH3 H H H H H 2,6DMB 678 CH3 H H H H H CD3 679 CH3 H H H H H CH3 680 CH3 H H H H H H 681 CH3 H H H H H i-Pr 682 CH3 H H H H i-Pr H 683 CH3 H H H i-Pr H H 684 CH3 H H i-Pr H H H 685 CH3 H i-Pr H H H H 686 CH3 i-Pr H H H H H 687 H 2,6DIP H CD3 H H H 688 H 2,6DIP H CH3 H H H 689 H 2,6DIP H H CD3 H H 690 H 2,6DIP H H CH3 H H 691 H 2,6DIP H H H CD3 H 692 H 2,6DIP H H H CH3 H 693 H 2,6DIP H H H H CD3 694 H 2,6DIP H H H H CH3 695 H 2,6DIP H H H H H 696 H 2,6DMB H CD3 H H H 697 H 2,6DMB H CH3 H H H 698 H 2,6DMB H H CD3 H H 699 H 2,6DMB H H CH3 H H 700 H 2,6DMB H H H CD3 H 701 H 2,6DMB H H H CH3 H 702 H 2,6DMB H H H H CD3 703 H 2,6DMB H H H H CH3 704 H 2,6DMB H H H H H 705 H CD3 CD3 H H H H 706 H CD3 CH3 H H H H 707 H CD3 H 2,6DIP H H H 708 H CD3 H 2,6DMB H H H 709 H CD3 H CD3 H H H 710 H CD3 H CH3 H H H 711 H CD3 H H 2,6DIP H H 712 H CD3 H H 2,6DMB H H 713 H CD3 H H CD3 H H 714 H CD3 H H CH3 H H 715 H CD3 H H H 2,6DIP H 716 H CD3 H H H 2,6DMB H 717 H CD3 H H H CD3 H 718 H CD3 H H H CH3 H 719 H CD3 H H H H 2,6DIP 720 H CD3 H H H H 2,6DMB 721 H CD3 H H H H CD3 722 H CD3 H H H H CH3 723 H CD3 H H H H H 724 H CD3 H H H H i-Pr 725 H CD3 H H H i-Pr H 726 H CD3 H H i-Pr H H 727 H CD3 H i-Pr H H H 728 H CD3 i-Pr H H H H 729 H CH3 CD3 H H H H 730 H CH3 CH3 H H H H 731 H CH3 H 2,6DIP H H H 732 H CH3 H 2,6DMB H H H 733 H CH3 H CD3 H H H 734 H CH3 H CH3 H H H 735 H CH3 H H 2,6DIP H H 736 H CH3 H H 2,6DMB H H 737 H CH3 H H CD3 H H 738 H CH3 H H CH3 H H 739 H CH3 H H H 2,6DIP H 740 H CH3 H H H 2,6DMB H 741 H CH3 H H H CD3 H 742 H CH3 H H H CH3 H 743 H CH3 H H H H 2,6DIP 744 H CH3 H H H H 2,6DMB 745 H CH3 H H H H CD3 746 H CH3 H H H H CH3 747 H CH3 H H H H H 748 H CH3 H H H H i-Pr 749 H CH3 H H H i-Pr H 750 H CH3 H H i-Pr H H 751 H CH3 H i-Pr H H H 752 H CH3 i-Pr H H H H 753 H H 2,6DIP H CD3 H H 754 H H 2,6DIP H CH3 H H 755 H H 2,6DIP H H CD3 H 756 H H 2,6DIP H H CH3 H 757 H H 2,6DIP H H H CD3 758 H H 2,6DIP H H H CH3 759 H H 2,6DIP H H H H 760 H H 2,6DMB H CD3 H H 761 H H 2,6DMB H CH3 H H 762 H H 2,6DMB H H CD3 H 763 H H 2,6DMB H H CH3 H 764 H H 2,6DMB H H H CD3 765 H H 2,6DMB H H H CH3 766 H H 2,6DMB H H H H 767 H H CD3 CD3 H H H 768 H H CD3 CH3 H H H 769 H H CD3 H 2,6DIP H H 770 H H CD3 H 2,6DMB H H 771 H H CD3 H CD3 H H 772 H H CD3 H CH3 H H 773 H H CD3 H H 2,6DIP H 774 H H CD3 H H 2,6DMB H 775 H H CD3 H H CD3 H 776 H H CD3 H H CH3 H 777 H H CD3 H H H 2,6DIP 778 H H CD3 H H H 2,6DMB 779 H H CD3 H H H CD3 780 H H CD3 H H H CH3 781 H H CD3 H H H H 782 H H CD3 H H H i-Pr 783 H H CD3 H H i-Pr H 784 H H CD3 H i-Pr H H 785 H H CD3 i-Pr H H H 786 H H CH3 CD3 H H H 787 H H CH3 CH3 H H H 788 H H CH3 H 2,6DIP H H 789 H H CH3 H 2,6DMB H H 790 H H CH3 H CD3 H H 791 H H CH3 H CH3 H H 792 H H CH3 H H 2,6DIP H 793 H H CH3 H H 2,6DMB H 794 H H CH3 H H CD3 H 795 H H CH3 H H CH3 H 796 H H CH3 H H H 2,6DIP 797 H H CH3 H H H 2,6DMB 798 H H CH3 H H H CD3 799 H H CH3 H H H CH3 800 H H CH3 H H H H 801 H H CH3 H H H i-Pr 802 H H CH3 H H i-Pr H 803 H H CH3 H i-Pr H H 804 H H CH3 i-Pr H H H 805 H H H 2,6DIP H CD3 H 806 H H H 2,6DIP H CH3 H 807 H H H 2,6DIP H H CD3 808 H H H 2,6DIP H H CH3 809 H H H 2,6DIP H H H 810 H H H 2,6DMB H CD3 H 811 H H H 2,6DMB H CH3 H 812 H H H 2,6DMB H H CD3 813 H H H 2,6DMB H H CH3 814 H H H 2,6DMB H H H 815 H H H CD3 CD3 H H 816 H H H CD3 CH3 H H 817 H H H CD3 H 2,6DIP H 818 H H H CD3 H 2,6DMB H 819 H H H CD3 H CD3 H 820 H H H CD3 H CH3 H 821 H H H CD3 H H 2,6DIP 822 H H H CD3 H H 2,6DMB 823 H H H CD3 H H CD3 824 H H H CD3 H H CH3 825 H H H CD3 H H H 826 H H H CD3 H H i-Pr 827 H H H CD3 H i-Pr H 828 H H H CD3 i-Pr H H 829 H H H CH3 CD3 H H 830 H H H CH3 CH3 H H 831 H H H CH3 H 2,6DIP H 832 H H H CH3 H 2,6DMB H 833 H H H CH3 H CD3 H 834 H H H CH3 H CH3 H 835 H H H CH3 H H 2,6DIP 836 H H H CH3 H H 2,6DMB 837 H H H CH3 H H CD3 838 H H H CH3 H H CH3 839 H H H CH3 H H H 840 H H H CH3 H H i-Pr 841 H H H CH3 H i-Pr H 842 H H H CH3 i-Pr H H 843 H H H H 2,6DIP CD3 H 844 H H H H 2,6DIP CH3 H 845 H H H H 2,6DIP H CD3 846 H H H H 2,6DIP H CH3 847 H H H H 2,6DIP H H 848 H H H H 2,6DMB CD3 H 849 H H H H 2,6DMB CH3 H 850 H H H H 2,6DMB H CD3 851 H H H H 2,6DMB H CH3 852 H H H H 2,6DMB H H 853 H H H H CD3 2,6DIP H 854 H H H H CD3 2,6DMB H 855 H H H H CD3 CD3 H 856 H H H H CD3 CH3 H 857 H H H H CD3 H 2,6DIP 858 H H H H CD3 H 2,6DMB 859 H H H H CD3 H CD3 860 H H H H CD3 H CH3 861 H H H H CD3 H H 862 H H H H CD3 H i-Pr 863 H H H H CD3 i-Pr H 864 H H H H CH3 2,6DIP H 865 H H H H CH3 2,6DMB H 866 H H H H CH3 CD3 H 867 H H H H CH3 CH3 H 868 H H H H CH3 H 2,6DIP 869 H H H H CH3 H 2,6DMB 870 H H H H CH3 H CD3 871 H H H H CH3 H CH3 872 H H H H CH3 H H 873 H H H H CH3 H i-Pr 874 H H H H CH3 i-Pr H 875 H H H H H 2,6DIP H 876 H H H H H 2,6DMB H 877 H H H H H CD3 CD3 878 H H H H H CD3 CH3 879 H H H H H CD3 H 880 H H H H H CD3 i-Pr 881 H H H H H CH3 CD3 882 H H H H H CH3 CH3 883 H H H H H CH3 H 884 H H H H H CH3 i-Pr 885 H H H H H H 2,6DIP 886 H H H H H H 2,6DMB 887 H H H H H H CD3 888 H H H H H H CH3 889 H H H H H H H 890 H H H H H H i-Pr 891 H H H H H i-Pr CD3 892 H H H H H i-Pr CH3 893 H H H H H i-Pr H 894 H H H H i-Pr CD3 H 895 H H H H i-Pr CH3 H 896 H H H H i-Pr H CD3 897 H H H H i-Pr H CH3 898 H H H H i-Pr H H 899 H H H i-Pr CD3 H H 900 H H H i-Pr CH3 H H 901 H H H i-Pr H CD3 H 902 H H H i-Pr H CH3 H 903 H H H i-Pr H H CD3 904 H H H i-Pr H H CH3 905 H H H i-Pr H H H 906 H H i-Pr CD3 H H H 907 H H i-Pr CH3 H H H 908 H H i-Pr H CD3 H H 909 H H i-Pr H CH3 H H 910 H H i-Pr H H CD3 H 911 H H i-Pr H H CH3 H 912 H H i-Pr H H H CD3 913 H H i-Pr H H H CH3 914 H H i-Pr H H H H 915 H i-Pr CD3 H H H H 916 H i-Pr CH3 H H H H 917 H i-Pr H CD3 H H H 918 H i-Pr H CH3 H H H 919 H i-Pr H H CD3 H H 920 H i-Pr H H CH3 H H 921 H i-Pr H H H CD3 H 922 H i-Pr H H H CH3 H 923 H i-Pr H H H H CD3 924 H i-Pr H H H H CH3 925 H i-Pr H H H H H 926 i-Pr CD3 H H H H H 927 i-Pr CH3 H H H H H 928 i-Pr H CD3 H H H H 929 i-Pr H CH3 H H H H 930 i-Pr H H CD3 H H H 931 i-Pr H H CH3 H H H 932 i-Pr H H H CD3 H H 933 i-Pr H H H CH3 H H 934 i-Pr H H H H CD3 H 935 i-Pr H H H H CH3 H 936 i-Pr H H H H H CD3 937 i-Pr H H H H H CH3 938 i-Pr H H H H H H LA939 to LA1248 based on the structure:

LA # R11 R12 R13 R14 R32 R33 R34 939 CD3 CD3 H H H H H 940 CD3 CH3 H H H H H 941 CD3 H 2,6DIP H H H H 942 CD3 H 2,6DMB H H H H 943 CD3 H CD3 H H H H 944 CD3 H CH3 H H H H 945 CD3 H H 2,6DIP H H H 946 CD3 H H 2,6DMB H H H 947 CD3 H H CD3 H H H 948 CD3 H H CH3 H H H 949 CD3 H H H 2,6DIP H H 950 CD3 H H H 2,6DMB H H 951 CD3 H H H CD3 H H 952 CD3 H H H CH3 H H 953 CD3 H H H H 2,6DIP H 954 CD3 H H H H 2,6DMB H 955 CD3 H H H H CD3 H 956 CD3 H H H H CH3 H 957 CD3 H H H H H 2,6DIP 958 CD3 H H H H H 2,6DMB 959 CD3 H H H H H CD3 960 CD3 H H H H H CH3 961 CD3 H H H H H H 962 CD3 H H H H H i-Pr 963 CD3 H H H H i-Pr H 964 CD3 H H H i-Pr H H 965 CD3 H H i-Pr H H H 966 CD3 H i-Pr H H H H 967 CD3 i-Pr H H H H H 968 CH3 CD3 H H H H H 969 CH3 CH3 H H H H H 970 CH3 H 2,6DIP H H H H 971 CH3 H 2,6DMB H H H H 972 CH3 H CD3 H H H H 973 CH3 H CH3 H H H H 974 CH3 H H 2,6DIP H H H 975 CH3 H H 2,6DMB H H H 976 CH3 H H CD3 H H H 977 CH3 H H CH3 H H H 978 CH3 H H H 2,6DIP H H 979 CH3 H H H 2,6DMB H H 980 CH3 H H H CD3 H H 981 CH3 H H H CH3 H H 982 CH3 H H H H 2,6DIP H 983 CH3 H H H H 2,6DMB H 984 CH3 H H H H CD3 H 985 CH3 H H H H CH3 H 986 CH3 H H H H H 2,6DIP 987 CH3 H H H H H 2,6DMB 988 CH3 H H H H H CD3 989 CH3 H H H H H CH3 990 CH3 H H H H H H 991 CH3 H H H H H i-Pr 992 CH3 H H H H i-Pr H 993 CH3 H H H i-Pr H H 994 CH3 H H i-Pr H H H 995 CH3 H i-Pr H H H H 996 CH3 i-Pr H H H H H 997 H 2,6DIP H CD3 H H H 998 H 2,6DIP H CH3 H H H 999 H 2,6DIP H H CD3 H H 1000 H 2,6DIP H H CH3 H H 1001 H 2,6DIP H H H CD3 H 1002 H 2,6DIP H H H CH3 H 1003 H 2,6DIP H H H H CD3 1004 H 2,6DIP H H H H CH3 1005 H 2,6DIP H H H H H 1006 H 2,6DMB H CD3 H H H 1007 H 2,6DMB H CH3 H H H 1008 H 2,6DMB H H CD3 H H 1009 H 2,6DMB H H CH3 H H 1010 H 2,6DMB H H H CD3 H 1011 H 2,6DMB H H H CH3 H 1012 H 2,6DMB H H H H CD3 1013 H 2,6DMB H H H H CH3 1014 H 2,6DMB H H H H H 1015 H CD3 CD3 H H H H 1016 H CD3 CH3 H H H H 1017 H CD3 H 2,6DIP H H H 1018 H CD3 H 2,6DMB H H H 1019 H CD3 H CD3 H H H 1020 H CD3 H CH3 H H H 1021 H CD3 H H 2,6DIP H H 1022 H CD3 H H 2,6DMB H H 1023 H CD3 H H CD3 H H 1024 H CD3 H H CH3 H H 1025 H CD3 H H H 2,6DIP H 1026 H CD3 H H H 2,6DMB H 1027 H CD3 H H H CD3 H 1028 H CD3 H H H CH3 H 1029 H CD3 H H H H 2,6DIP 1030 H CD3 H H H H 2,6DMB 1031 H CD3 H H H H CD3 1032 H CD3 H H H H CH3 1033 H CD3 H H H H H 1034 H CD3 H H H H i-Pr 1035 H CD3 H H H i-Pr H 1036 H CD3 H H i-Pr H H 1037 H CD3 H i-Pr H H H 1038 H CD3 i-Pr H H H H 1039 H CH3 CD3 H H H H 1040 H CH3 CH3 H H H H 1041 H CH3 H 2,6DIP H H H 1042 H CH3 H 2,6DMB H H H 1043 H CH3 H CD3 H H H 1044 H CH3 H CH3 H H H 1045 H CH3 H H 2,6DIP H H 1046 H CH3 H H 2,6DMB H H 1047 H CH3 H H CD3 H H 1048 H CH3 H H CH3 H H 1049 H CH3 H H H 2,6DIP H 1050 H CH3 H H H 2,6DMB H 1051 H CH3 H H H CD3 H 1052 H CH3 H H H CH3 H 1053 H CH3 H H H H 2,6DIP 1054 H CH3 H H H H 2,6DMB 1055 H CH3 H H H H CD3 1056 H CH3 H H H H CH3 1057 H CH3 H H H H H 1058 H CH3 H H H H i-Pr 1059 H CH3 H H H i-Pr H 1060 H CH3 H H i-Pr H H 1061 H CH3 H i-Pr H H H 1062 H CH3 i-Pr H H H H 1063 H H 2,6DIP H CD3 H H 1064 H H 2,6DIP H CH3 H H 1065 H H 2,6DIP H H CD3 H 1066 H H 2,6DIP H H CH3 H 1067 H H 2,6DIP H H H CD3 1068 H H 2,6DIP H H H CH3 1069 H H 2,6DIP H H H H 1070 H H 2,6DMB H CD3 H H 1071 H H 2,6DMB H CH3 H H 1072 H H 2,6DMB H H CD3 H 1073 H H 2,6DMB H H CH3 H 1074 H H 2,6DMB H H H CD3 1075 H H 2,6DMB H H H CH3 1076 H H 2,6DMB H H H H 1077 H H CD3 CD3 H H H 1078 H H CD3 CH3 H H H 1079 H H CD3 H 2,6DIP H H 1080 H H CD3 H 2,6DMB H H 1081 H H CD3 H CD3 H H 1082 H H CD3 H CH3 H H 1083 H H CD3 H H 2,6DIP H 1084 H H CD3 H H 2,6DMB H 1085 H H CD3 H H CD3 H 1086 H H CD3 H H CH3 H 1087 H H CD3 H H H 2,6DIP 1088 H H CD3 H H H 2,6DMB 1089 H H CD3 H H H CD3 1090 H H CD3 H H H CH3 1091 H H CD3 H H H H 1092 H H CD3 H H H i-Pr 1093 H H CD3 H H i-Pr H 1094 H H CD3 H i-Pr H H 1095 H H CD3 i-Pr H H H 1096 H H CH3 CD3 H H H 1097 H H CH3 CH3 H H H 1098 H H CH3 H 2,6DIP H H 1099 H H CH3 H 2,6DMB H H 1100 H H CH3 H CD3 H H 1101 H H CH3 H CH3 H H 1102 H H CH3 H H 2,6DIP H 1103 H H CH3 H H 2,6DMB H 1104 H H CH3 H H CD3 H 1105 H H CH3 H H CH3 H 1106 H H CH3 H H H 2,6DIP 1107 H H CH3 H H H 2,6DMB 1108 H H CH3 H H H CD3 1109 H H CH3 H H H CH3 1110 H H CH3 H H H H 1111 H H CH3 H H H i-Pr 1112 H H CH3 H H i-Pr H 1113 H H CH3 H i-Pr H H 1114 H H CH3 i-Pr H H H 1115 H H H 2,6DIP CD3 H H 1116 H H H 2,6DIP CH3 H H 1117 H H H 2,6DIP H CD3 H 1118 H H H 2,6DIP H CH3 H 1119 H H H 2,6DIP H H CD3 1120 H H H 2,6DIP H H CH3 1121 H H H 2,6DIP H H H 1122 H H H 2,6DMB CD3 H H 1123 H H H 2,6DMB CH3 H H 1124 H H H 2,6DMB H CD3 H 1125 H H H 2,6DMB H CH3 H 1126 H H H 2,6DMB H H CD3 1127 H H H 2,6DMB H H CH3 1128 H H H 2,6DMB H H H 1129 H H H CD3 2,6DIP H H 1130 H H H CD3 2,6DMB H H 1131 H H H CD3 CD3 H H 1132 H H H CD3 CH3 H H 1133 H H H CD3 H 2,6DIP H 1134 H H H CD3 H 2,6DMB H 1135 H H H CD3 H CD3 H 1136 H H H CD3 H CH3 H 1137 H H H CD3 H H 2,6DIP 1138 H H H CD3 H H 2,6DMB 1139 H H H CD3 H H CD3 1140 H H H CD3 H H CH3 1141 H H H CD3 H H H 1142 H H H CD3 H H i-Pr 1143 H H H CD3 H i-Pr H 1144 H H H CD3 i-Pr H H 1145 H H H CH3 2,6DIP H H 1146 H H H CH3 2,6DMB H H 1147 H H H CH3 CD3 H H 1148 H H H CH3 CH3 H H 1149 H H H CH3 H 2,6DIP H 1150 H H H CH3 H 2,6DMB H 1151 H H H CH3 H CD3 H 1152 H H H CH3 H CH3 H 1153 H H H CH3 H H 2,6DIP 1154 H H H CH3 H H 2,6DMB 1155 H H H CH3 H H CD3 1156 H H H CH3 H H CH3 1157 H H H CH3 H H H 1158 H H H CH3 H H i-Pr 1159 H H H CH3 H i-Pr H 1160 H H H CH3 i-Pr H H 1161 H H H H 2,6DIP H CD3 1162 H H H H 2,6DIP H CH3 1163 H H H H 2,6DIP H H 1164 H H H H 2,6DMB H CD3 1165 H H H H 2,6DMB H CH3 1166 H H H H 2,6DMB H H 1167 H H H H CD3 CD3 H 1168 H H H H CD3 CH3 H 1169 H H H H CD3 H 2,6DIP 1170 H H H H CD3 H 2,6DMB 1171 H H H H CD3 H CD3 1172 H H H H CD3 H CH3 1173 H H H H CD3 H H 1174 H H H H CD3 H i-Pr 1175 H H H H CD3 i-Pr H 1176 H H H H CH3 CD3 H 1177 H H H H CH3 CH3 H 1178 H H H H CH3 H 2,6DIP 1179 H H H H CH3 H 2,6DMB 1180 H H H H CH3 H CD3 1181 H H H H CH3 H CH3 1182 H H H H CH3 H H 1183 H H H H CH3 H i-Pr 1184 H H H H CH3 i-Pr H 1185 H H H H H 2,6DIP H 1186 H H H H H 2,6DMB H 1187 H H H H H CD3 CD3 1188 H H H H H CD3 CH3 1189 H H H H H CD3 H 1190 H H H H H CD3 i-Pr 1191 H H H H H CH3 CD3 1192 H H H H H CH3 CH3 1193 H H H H H CH3 H 1194 H H H H H CH3 i-Pr 1195 H H H H H H 2,6DIP 1196 H H H H H H 2,6DMB 1197 H H H H H H CD3 1198 H H H H H H CH3 1199 H H H H H H H 1200 H H H H H H i-Pr 1201 H H H H H i-Pr CD3 1202 H H H H H i-Pr CH3 1203 H H H H H i-Pr H 1204 H H H H i-Pr CD3 H 1205 H H H H i-Pr CH3 H 1206 H H H H i-Pr H CD3 1207 H H H H i-Pr H CH3 1208 H H H H i-Pr H H 1209 H H H i-Pr CD3 H H 1210 H H H i-Pr CH3 H H 1211 H H H i-Pr H CD3 H 1212 H H H i-Pr H CH3 H 1213 H H H i-Pr H H CD3 1214 H H H i-Pr H H CH3 1215 H H H i-Pr H H H 1216 H H i-Pr CD3 H H H 1217 H H i-Pr CH3 H H H 1218 H H i-Pr H CD3 H H 1219 H H i-Pr H CH3 H H 1220 H H i-Pr H H CD3 H 1221 H H i-Pr H H CH3 H 1222 H H i-Pr H H H CD3 1223 H H i-Pr H H H CH3 1224 H H i-Pr H H H H 1225 H i-Pr CD3 H H H H 1226 H i-Pr CH3 H H H H 1227 H i-Pr H CD3 H H H 1228 H i-Pr H CH3 H H H 1229 H i-Pr H H CD3 H H 1230 H i-Pr H H CH3 H H 1231 H i-Pr H H H CD3 H 1232 H i-Pr H H H CH3 H 1233 H i-Pr H H H H CD3 1234 H i-Pr H H H H CH3 1235 H i-Pr H H H H H 1236 i-Pr CD3 H H H H H 1237 i-Pr CH3 H H H H H 1238 i-Pr H CD3 H H H H 1239 i-Pr H CH3 H H H H 1240 i-Pr H H CD3 H H H 1241 i-Pr H H CH3 H H H 1242 i-Pr H H H CD3 H H 1243 i-Pr H H H CH3 H H 1244 i-Pr H H H H CD3 H 1245 i-Pr H H H H CH3 H 1246 i-Pr H H H H H CD3 1247 i-Pr H H H H H CH3 1248 i-Pr H H H H H H LA1249 to LA1720 based on structure:

LA # R11 R12 R2 R31 R32 R33 1249 CD3 CD3 2,6DIP H H H 1250 CD3 H 2,6DIPB H H H 1251 CD3 CD3 2,6DMB H H H 1252 CD3 CD3 CD3 H H H 1253 CD3 CD3 CH3 H H H 1254 CD3 CD3 H H H H 1255 CD3 CD3 ph H H H 1256 CD3 CH3 2,6DIP H H H 1257 CD3 CH3 2,6DIPB H H H 1258 CD3 CH3 2,6DMB H H H 1259 CD3 CH3 CD3 H H H 1260 CD3 CH3 CH3 H H H 1261 CD3 CH3 H H H H 1262 CD3 CH3 ph H H H 1263 CD3 H 2,6DIP CD3 H H 1264 CD3 H 2,6DIP CH3 H H 1265 CD3 H 2,6DIP H CD3 H 1266 CD3 H 2,6DIP H CH3 H 1267 CD3 H 2,6DIP H H CD3 1268 CD3 H 2,6DIP H H CH3 1269 CD3 H 2,6DIP H H H 1270 CD3 H 2,6DIPB CD3 H H 1271 CD3 H 2,6DIPB CH3 H H 1272 CD3 H 2,6DIPB H CD3 H 1273 CD3 H 2,6DIPB H CH3 H 1274 CD3 H 2,6DIPB H H CD3 1275 CD3 H 2,6DIPB H H CH3 1276 CD3 H 2,6DIPB H H H 1277 CD3 H 2,6DMB CD3 H H 1278 CD3 H 2,6DMB CH3 H H 1279 CD3 H 2,6DMB H CD3 H 1280 CD3 H 2,6DMB H CH3 H 1281 CD3 H 2,6DMB H H CD3 1282 CD3 H 2,6DMB H H CH3 1283 CD3 H 2,6DMB H H H 1284 CD3 H CD3 CD3 H H 1285 CD3 H CD3 CH3 H H 1286 CD3 H CD3 H CD3 H 1287 CD3 H CD3 H CH3 H 1288 CD3 H CD3 H H CD3 1289 CD3 H CD3 H H CH3 1290 CD3 H CD3 H H H 1291 CD3 H CH3 CD3 H H 1292 CD3 H CH3 CH3 H H 1293 CD3 H CH3 H CD3 H 1294 CD3 H CH3 H CH3 H 1295 CD3 H CH3 H H CD3 1296 CD3 H CH3 H H CH3 1297 CD3 H CH3 H H H 1298 CD3 H H 2,6DIP H H 1299 CD3 H H 2,6DMB H H 1300 CD3 H H CD3 H H 1301 CD3 H H CH3 H H 1302 CD3 H H H 2,6DIP H 1303 CD3 H H H 2,6DMB H 1304 CD3 H H H CD3 H 1305 CD3 H H H CH3 H 1306 CD3 H H H H 2,6DIP 1307 CD3 H H H H 2,6DMB 1308 CD3 H H H H CD3 1309 CD3 H H H H CH3 1310 CD3 H H H H H 1311 CD3 H H H H iPr 1312 CD3 H H H iPr H 1313 CD3 H H iPr H H 1314 CD3 H ph CD3 H H 1315 CD3 H ph CH3 H H 1316 CD3 H ph H CD3 H 1317 CD3 H ph H CH3 H 1318 CD3 H ph H H CD3 1319 CD3 H ph H H CH3 1320 CD3 H ph H H H 1321 CD3 iPr H H H H 1322 CH3 CD3 2,6DIP H H H 1323 CH3 CD3 2,6DIPB H H H 1324 CH3 CD3 2,6DMB H H H 1325 CH3 CD3 CD3 H H H 1326 CH3 CD3 CH3 H H H 1327 CH3 CD3 H H H H 1328 CH3 CD3 ph H H H 1329 CH3 CH3 2,6DIP H H H 1330 CH3 CH3 2,6DIPB H H H 1331 CH3 CH3 2,6DMB H H H 1332 CH3 CH3 CD3 H H H 1333 CH3 CH3 CH3 H H H 1334 CH3 CH3 H H H H 1335 CH3 CH3 ph H H H 1336 CH3 H 2,6DIP CD3 H H 1337 CH3 H 2,6DIP CH3 H H 1338 CH3 H 2,6DIP H CD3 H 1339 CH3 H 2,6DIP H CH3 H 1340 CH3 H 2,6DIP H H CD3 1341 CH3 H 2,6DIP H H CH3 1342 CH3 H 2,6DIP H H H 1343 CH3 H 2,6DIPB CD3 H H 1344 CH3 H 2,6DIPB CH3 H H 1345 CH3 H 2,6DIPB H CD3 H 1346 CH3 H 2,6DIPB H CH3 H 1347 CH3 H 2,6DIPB H H CD3 1348 CH3 H 2,6DIPB H H CH3 1349 CH3 H 2,6DIPB H H H 1350 CH3 H 2,6DMB CD3 H H 1351 CH3 H 2,6DMB CH3 H H 1352 CH3 H 2,6DMB H CD3 H 1353 CH3 H 2,6DMB H CH3 H 1354 CH3 H 2,6DMB H H CD3 1355 CH3 H 2,6DMB H H CH3 1356 CH3 H 2,6DMB H H H 1357 CH3 H CD3 CD3 H H 1358 CH3 H CD3 CH3 H H 1359 CH3 H CD3 H CD3 H 1360 CH3 H CD3 H CH3 H 1361 CH3 H CD3 H H CD3 1362 CH3 H CD3 H H CH3 1363 CH3 H CD3 H H H 1364 CH3 H CH3 CD3 H H 1365 CH3 H CH3 CH3 H H 1366 CH3 H CH3 H CD3 H 1367 CH3 H CH3 H CH3 H 1368 CH3 H CH3 H H CD3 1369 CH3 H CH3 H H CH3 1370 CH3 H CH3 H H H 1371 CH3 H H 2,6DIP H H 1372 CH3 H H 2,6DMB H H 1373 CH3 H H CD3 H H 1374 CH3 H H CH3 H H 1375 CH3 H H H 2,6DIP H 1376 CH3 H H H 2,6DMB H 1377 CH3 H H H CD3 H 1378 CH3 H H H CH3 H 1379 CH3 H H H H 2,6DIP 1380 CH3 H H H H 2,6DMB 1381 CH3 H H H H CD3 1382 CH3 H H H H CH3 1383 CH3 H H H H H 1384 CH3 H H H H iPr 1385 CH3 H H H iPr H 1386 CH3 H H iPr H H 1387 CH3 H ph CD3 H H 1388 CH3 H ph CH3 H H 1389 CH3 H ph H CD3 H 1390 CH3 H ph H CH3 H 1391 CH3 H ph H H CD3 1392 CH3 H ph H H CH3 1393 CH3 H ph H H H 1394 CH3 iPr H H H H 1395 H 2,6DIP H CD3 H H 1396 H 2,6DIP H CH3 H H 1397 H 2,6DIP H H CD3 H 1398 H 2,6DIP H H CH3 H 1399 H 2,6DIP H H H CD3 1400 H 2,6DIP H H H CH3 1401 H 2,6DIP H H H H 1402 H 2,6DMB H CD3 H H 1403 H 2,6DMB H CH3 H H 1404 H 2,6DMB H H CD3 H 1405 H 2,6DMB H H CH3 H 1406 H 2,6DMB H H H CD3 1407 H 2,6DMB H H H CH3 1408 H 2,6DMB H H H H 1409 H CD3 2,6DIP CD3 H H 1410 H CD3 2,6DIP CH3 H H 1411 H CD3 2,6DIP H CD3 H 1412 H CD3 2,6DIP H CH3 H 1413 H CD3 2,6DIP H H CD3 1414 H CD3 2,6DIP H H CH3 1415 H CD3 2,6DIP H H H 1416 H CD3 2,6DIPB CD3 H H 1417 H CD3 2,6DIPB CH3 H H 1418 H CD3 2,6DIPB H CD3 H 1419 H CD3 2,6DIPB H CH3 H 1420 H CD3 2,6DIPB H H CD3 1421 H CD3 2,6DIPB H H CH3 1422 H CD3 2,6DIPB H H H 1423 H CD3 2,6DMB CD3 H H 1424 H CD3 2,6DMB CH3 H H 1425 H CD3 2,6DMB H CD3 H 1426 H CD3 2,6DMB H CH3 H 1427 H CD3 2,6DMB H H CD3 1428 H CD3 2,6DMB H H CH3 1429 H CD3 2,6DMB H H H 1430 H CD3 CD3 CD3 H H 1431 H CD3 CD3 CH3 H H 1432 H CD3 CD3 H CD3 H 1433 H CD3 CD3 H CH3 H 1434 H CD3 CD3 H H CD3 1435 H CD3 CD3 H H CH3 1436 H CD3 CD3 H H H 1437 H CD3 CH3 CD3 H H 1438 H CD3 CH3 CH3 H H 1439 H CD3 CH3 H CD3 H 1440 H CD3 CH3 H CH3 H 1441 H CD3 CH3 H H CD3 1442 H CD3 CH3 H H CH3 1443 H CD3 CH3 H H H 1444 H CD3 H 2,6DIP H H 1445 H CD3 H 2,6DMB H H 1446 H CD3 H CD3 H H 1447 H CD3 H CH3 H H 1448 H CD3 H H 2,6DIP H 1449 H CD3 H H 2,6DMB H 1450 H CD3 H H CD3 H 1451 H CD3 H H CH3 H 1452 H CD3 H H H 2,6DIP 1453 H CD3 H H H 2,6DMB 1454 H CD3 H H H CD3 1455 H CD3 H H H CH3 1456 H CD3 H H H H 1457 H CD3 H H H iPr 1458 H CD3 H H iPr H 1459 H CD3 H iPr H H 1460 H CD3 ph CD3 H H 1461 H CD3 ph CH3 H H 1462 H CD3 ph H CD3 H 1463 H CD3 ph H CH3 H 1464 H CD3 ph H H CD3 1465 H CD3 ph H H CH3 1466 H CD3 ph H H H 1467 H CH3 2,6DIP CD3 H H 1468 H CH3 2,6DIP CH3 H H 1469 H CH3 2,6DIP H CD3 H 1470 H CH3 2,6DIP H CH3 H 1471 H CH3 2,6DIP H H CD3 1472 H CH3 2,6DIP H H CH3 1473 H CH3 2,6DIP H H H 1474 H CH3 2,6DIPB CD3 H H 1475 H CH3 2,6DIPB CH3 H H 1476 H CH3 2,6DIPB H CD3 H 1477 H CH3 2,6DIPB H CH3 H 1478 H CH3 2,6DIPB H H CD3 1479 H CH3 2,6DIPB H H CH3 1480 H CH3 2,6DIPB H H H 1481 H CH3 2,6DMB CD3 H H 1482 H CH3 2,6DMB CH3 H H 1483 H CH3 2,6DMB H CD3 H 1484 H CH3 2,6DMB H CH3 H 1485 H CH3 2,6DMB H H CD3 1486 H CH3 2,6DMB H H CH3 1487 H CH3 2,6DMB H H H 1488 H CH3 CD3 CD3 H H 1489 H CH3 CD3 CH3 H H 1490 H CH3 CD3 H CD3 H 1491 H CH3 CD3 H CH3 H 1492 H CH3 CD3 H H CD3 1493 H CH3 CD3 H H CH3 1494 H CH3 CD3 H H H 1495 H CH3 CH3 CD3 H H 1496 H CH3 CH3 CH3 H H 1497 H CH3 CH3 H CD3 H 1498 H CH3 CH3 H CH3 H 1499 H CH3 CH3 H H CD3 1500 H CH3 CH3 H H CH3 1501 H CH3 CH3 H H H 1502 H CH3 H 2,6DIP H H 1503 H CH3 H 2,6DMB H H 1504 H CH3 H CD3 H H 1505 H CH3 H CH3 H H 1506 H CH3 H H 2,6DIP H 1507 H CH3 H H 2,6DMB H 1508 H CH3 H H CD3 H 1509 H CH3 H H CH3 H 1510 H CH3 H H H 2,6DIP 1511 H CH3 H H H 2,6DMB 1512 H CH3 H H H CD3 1513 H CH3 H H H CH3 1514 H CH3 H H H H 1515 H CH3 H H H iPr 1516 H CH3 H H iPr H 1517 H CH3 H iPr H H 1518 H CH3 ph CD3 H H 1519 H CH3 ph CH3 H H 1520 H CH3 ph H CD3 H 1521 H CH3 ph H CH3 H 1522 H CH3 ph H H CD3 1523 H CH3 ph H H CH3 1524 H CH3 ph H H H 1525 H H 2,6DIP CD3 CD3 H 1526 H H 2,6DIP CD3 CH3 H 1527 H H 2,6DIP CD3 H CD3 1528 H H 2,6DIP CD3 H CH3 1529 H H 2,6DIP CD3 H H 1530 H H 2,6DIP CH3 CD3 H 1531 H H 2,6DIP CH3 CH3 H 1532 H H 2,6DIP CH3 H CD3 1533 H H 2,6DIP CH3 H CH3 1534 H H 2,6DIP CH3 H H 1535 H H 2,6DIP H CD3 CD3 1536 H H 2,6DIP H CD3 CH3 1537 H H 2,6DIP H CD3 H 1538 H H 2,6DIP H CH3 CD3 1539 H H 2,6DIP H CH3 CH3 1540 H H 2,6DIP H CH3 H 1541 H H 2,6DIP H H CD3 1542 H H 2,6DIP H H CH3 1543 H H 2,6DIP H H H 1544 H H 2,6DIPB CD3 CD3 H 1545 H H 2,6DIPB CD3 CH3 H 1546 H H 2,6DIPB CD3 H CD3 1547 H H 2,6DIPB CD3 H CH3 1548 H H 2,6DIPB CD3 H H 1549 H H 2,6DIPB CH3 CD3 H 1550 H H 2,6DIPB CH3 CH3 H 1551 H H 2,6DIPB CH3 H CD3 1552 H H 2,6DIPB CH3 H CH3 1553 H H 2,6DIPB CH3 H H 1554 H H 2,6DIPB H CD3 CD3 1555 H H 2,6DIPB H CD3 CH3 1556 H H 2,6DIPB H CD3 H 1557 H H 2,6DIPB H CH3 CD3 1558 H H 2,6DIPB H CH3 CH3 1559 H H 2,6DIPB H CH3 H 1560 H H 2,6DIPB H H CD3 1561 H H 2,6DIPB H H CH3 1562 H H 2,6DIPB H H H 1563 H H 2,6DMB CD3 CD3 H 1564 H H 2,6DMB CD3 CH3 H 1565 H H 2,6DMB CD3 H CD3 1566 H H 2,6DMB CD3 H CH3 1567 H H 2,6DMB CD3 H H 1568 H H 2,6DMB CH3 CD3 H 1569 H H 2,6DMB CH3 CH3 H 1570 H H 2,6DMB CH3 H CD3 1571 H H 2,6DMB CH3 H CH3 1572 H H 2,6DMB CH3 H H 1573 H H 2,6DMB H CD3 CD3 1574 H H 2,6DMB H CD3 CH3 1575 H H 2,6DMB H CD3 H 1576 H H 2,6DMB H CH3 CD3 1577 H H 2,6DMB H CH3 CH3 1578 H H 2,6DMB H CH3 H 1579 H H 2,6DMB H H CD3 1580 H H 2,6DMB H H CH3 1581 H H 2,6DMB H H H 1582 H H CD3 CD3 CD3 H 1583 H H CD3 CD3 CH3 H 1584 H H CD3 CD3 H CD3 1585 H H CD3 CD3 H CH3 1586 H H CD3 CD3 H H 1587 H H CD3 CH3 CD3 H 1588 H H CD3 CH3 CH3 H 1589 H H CD3 CH3 H CD3 1590 H H CD3 CH3 H CH3 1591 H H CD3 CH3 H H 1592 H H CD3 H 2,6DIP H 1593 H H CD3 H 2,6DMB H 1594 H H CD3 H CD3 CD3 1595 H H CD3 H CD3 CH3 1596 H H CD3 H CD3 H 1597 H H CD3 H CH3 CD3 1598 H H CD3 H CH3 CH3 1599 H H CD3 H CH3 H 1600 H H CD3 H H 2,6DIP 1601 H H CD3 H H 2,6DMB 1602 H H CD3 H H CD3 1603 H H CD3 H H CH3 1604 H H CD3 H H H 1605 H H CD3 H H iPr 1606 H H CD3 H iPr H 1607 H H CD3 iPr H H 1608 H H CH3 CD3 CD3 H 1609 H H CH3 CD3 CH3 H 1610 H H CH3 CD3 H CD3 1611 H H CH3 CD3 H CH3 1612 H H CH3 CD3 H H 1613 H H CH3 CH3 CD3 H 1614 H H CH3 CH3 CH3 H 1615 H H CH3 CH3 H CD3 1616 H H CH3 CH3 H CH3 1617 H H CH3 CH3 H H 1618 H H CH3 H 2,6DIP H 1619 H H CH3 H 2,6DMB H 1620 H H CH3 H CD3 CD3 1621 H H CH3 H CD3 CH3 1622 H H CH3 H CD3 H 1623 H H CH3 H CH3 CD3 1624 H H CH3 H CH3 CH3 1625 H H CH3 H CH3 H 1626 H H CH3 H H 2,6DIP 1627 H H CH3 H H 2,6DMB 1628 H H CH3 H H CD3 1629 H H CH3 H H CH3 1630 H H CH3 H H H 1631 H H CH3 H H iPr 1632 H H CH3 H iPr H 1633 H H CH3 iPr H H 1634 H H H 2,6DIP H CD3 1635 H H H 2,6DIP H CH3 1636 H H H 2,6DIP H H 1637 H H H 2,6DMB H CD3 1638 H H H 2,6DMB H CH3 1639 H H H 2,6DMB H H 1640 H H H CD3 CD3 H 1641 H H H CD3 CH3 H 1642 H H H CD3 H 2,6DIP 1643 H H H CD3 H 2,6DMB 1644 H H H CD3 H CD3 1645 H H H CD3 H CH3 1646 H H H CD3 H H 1647 H H H CD3 H iPr 1648 H H H CD3 iPr H 1649 H H H CH3 CD3 H 1650 H H H CH3 CH3 H 1651 H H H CH3 H 2,6DIP 1652 H H H CH3 H 2,6DMB 1653 H H H CH3 H CD3 1654 H H H CH3 H CH3 1655 H H H CH3 H H 1656 H H H CH3 H iPr 1657 H H H CH3 iPr H 1658 H H H H 2,6DIP H 1659 H H H H 2,6DMB H 1660 H H H H CD3 CD3 1661 H H H H CD3 CH3 1662 H H H H CD3 H 1663 H H H H CD3 iPr 1664 H H H H CH3 CD3 1665 H H H H CH3 CH3 1666 H H H H CH3 H 1667 H H H H CH3 iPr 1668 H H H H H 2,6DIP 1669 H H H H H 2,6DMB 1670 H H H H H CD3 1671 H H H H H CH3 1672 H H H H H H 1673 H H H H H iPr 1674 H H H H iPr CD3 1675 H H H H iPr CH3 1676 H H H H iPr H 1677 H H H iPr CD3 H 1678 H H H iPr CH3 H 1679 H H H iPr H CD3 1680 H H H iPr H CH3 1681 H H H iPr H H 1682 H H ph CD3 CD3 H 1683 H H ph CD3 CH3 H 1684 H H ph CD3 H CD3 1685 H H ph CD3 H CH3 1686 H H ph CD3 H H 1687 H H ph CH3 CD3 H 1688 H H ph CH3 CH3 H 1689 H H ph CH3 H CD3 1690 H H ph CH3 H CH3 1691 H H ph CH3 H H 1692 H H ph H CD3 CD3 1693 H H ph H CD3 CH3 1694 H H ph H CD3 H 1695 H H ph H CH3 CD3 1696 H H ph H CH3 CH3 1697 H H ph H CH3 H 1698 H H ph H H CD3 1699 H H ph H H CH3 1700 H H ph H H H 1701 H iPr CD3 H H H 1702 H iPr CH3 H H H 1703 H iPr H CD3 H H 1704 H iPr H CH3 H H 1705 H iPr H H CD3 H 1706 H iPr H H CH3 H 1707 H iPr H H H CD3 1708 H iPr H H H CH3 1709 H iPr H H H H 1710 iPr CD3 H H H H 1711 iPr CH3 H H H H 1712 iPr H CD3 H H H 1713 iPr H CH3 H H H 1714 iPr H H CD3 H H 1715 iPr H H CH3 H H 1716 iPr H H H CD3 H 1717 iPr H H H CH3 H 1718 iPr H H H H CD3 1719 iPr H H H H CH3 1720 iPr H H H H H LA1721 to LA2200 based on structure:

LA # R11 R12 R2 R31 R32 R34 1721 CD3 CD3 2,6DIP H H H 1722 CD3 CD3 2,6DIPB H H H 1723 CD3 CD3 2,6DMB H H H 1724 CD3 CD3 CD3 H H H 1725 CD3 CD3 CH3 H H H 1726 CD3 CD3 H H H H 1727 CD3 CD3 ph H H H 1728 CD3 CH3 2,6DIP H H H 1729 CD3 CH3 2,6DIPB H H H 1730 CD3 CH3 2,6DMB H H H 1731 CD3 CH3 CD3 H H H 1732 CD3 CH3 CH3 H H H 1733 CD3 CH3 H H H H 1734 CD3 CH3 ph H H H 1735 CD3 H 2,6DIP CD3 H H 1736 CD3 H 2,6DIP CH3 H H 1737 CD3 H 2,6DIP H CD3 H 1738 CD3 H 2,6DIP H CH3 H 1739 CD3 H 2,6DIP H H CD3 1740 CD3 H 2,6DIP H H CH3 1741 CD3 H 2,6DIP H H H 1742 CD3 H 2,6DIPB CD3 H H 1743 CD3 H 2,6DIPB CH3 H H 1744 CD3 H 2,6DIPB H CD3 H 1745 CD3 H 2,6DIPB H CH3 H 1746 CD3 H 2,6DIPB H H CD3 1747 CD3 H 2,6DIPB H H CH3 1748 CD3 H 2,6DIPB H H H 1749 CD3 H 2,6DMB CD3 H H 1750 CD3 H 2,6DMB CH3 H H 1751 CD3 H 2,6DMB H CD3 H 1752 CD3 H 2,6DMB H CH3 H 1753 CD3 H 2,6DMB H H CD3 1754 CD3 H 2,6DMB H H CH3 1755 CD3 H 2,6DMB H H H 1756 CD3 H CD3 CD3 H H 1757 CD3 H CD3 CH3 H H 1758 CD3 H CD3 H CD3 H 1759 CD3 H CD3 H CH3 H 1760 CD3 H CD3 H H CD3 1761 CD3 H CD3 H H CH3 1762 CD3 H CD3 H H H 1763 CD3 H CH3 CD3 H H 1764 CD3 H CH3 CH3 H H 1765 CD3 H CH3 H CD3 H 1766 CD3 H CH3 H CH3 H 1767 CD3 H CH3 H H CD3 1768 CD3 H CH3 H H CH3 1769 CD3 H CH3 H H H 1770 CD3 H H 2,6DIP H H 1771 CD3 H H 2,6DMB H H 1772 CD3 H H CD3 H H 1773 CD3 H H CH3 H H 1774 CD3 H H H 2,6DIP H 1775 CD3 H H H 2,6DMB H 1776 CD3 H H H CD3 H 1777 CD3 H H H CH3 H 1778 CD3 H H H H 2,6DIP 1779 CD3 H H H H 2,6DMB 1780 CD3 H H H H CD3 1781 CD3 H H H H CH3 1782 CD3 H H H H H 1783 CD3 H H H H iPr 1784 CD3 H H H iPr H 1785 CD3 H H iPr H H 1786 CD3 H ph CD3 H H 1787 CD3 H ph CH3 H H 1788 CD3 H ph H CD3 H 1789 CD3 H ph H CH3 H 1790 CD3 H ph H H CD3 1791 CD3 H ph H H CH3 1792 CD3 H ph H H H 1793 CD3 iPr H H H H 1794 CH3 CD3 2,6DIP H H H 1795 CH3 CD3 2,6DIPB H H H 1796 CH3 CD3 2,6DMB H H H 1797 CH3 CD3 CD3 H H H 1798 CH3 CD3 CH3 H H H 1799 CH3 CD3 H H H H 1800 CH3 CD3 ph H H H 1801 CH3 CH3 2,6DIP H H H 1802 CH3 CH3 2,6DIPB H H H 1803 CH3 CH3 2,6DMB H H H 1804 CH3 CH3 CD3 H H H 1805 CH3 CH3 CH3 H H H 1806 CH3 CH3 H H H H 1807 CH3 CH3 ph H H H 1808 CH3 H 2,6DIP CD3 H H 1809 CH3 H 2,6DIP CH3 H H 1810 CH3 H 2,6DIP H CD3 H 1811 CH3 H 2,6DIP H CH3 H 1812 CH3 H 2,6DIP H H CD3 1813 CH3 H 2,6DIP H H CH3 1814 CH3 H 2,6DIP H H H 1815 CH3 H 2,6DIPB CD3 H H 1816 CH3 H 2,6DIPB CH3 H H 1817 CH3 H 2,6DIPB H CD3 H 1818 CH3 H 2,6DIPB H CH3 H 1819 CH3 H 2,6DIPB H H CD3 1820 CH3 H 2,6DIPB H H CH3 1821 CH3 H 2,6DIPB H H H 1822 CH3 H 2,6DMB CD3 H H 1823 CH3 H 2,6DMB CH3 H H 1824 CH3 H 2,6DMB H CD3 H 1825 CH3 H 2,6DMB H CH3 H 1826 CH3 H 2,6DMB H H CD3 1827 CH3 H 2,6DMB H H CH3 1828 CH3 H 2,6DMB H H H 1829 CH3 H CD3 CD3 H H 1830 CH3 H CD3 CH3 H H 1831 CH3 H CD3 H CD3 H 1832 CH3 H CD3 H CH3 H 1833 CH3 H CD3 H H CD3 1834 CH3 H CD3 H H CH3 1835 CH3 H CD3 H H H 1836 CH3 H CH3 CD3 H H 1837 CH3 H CH3 CH3 H H 1838 CH3 H CH3 H CD3 H 1839 CH3 H CH3 H CH3 H 1840 CH3 H CH3 H H CD3 1841 CH3 H CH3 H H CH3 1842 CH3 H CH3 H H H 1843 CH3 H H 2,6DIP H H 1844 CH3 H H 2,6DMB H H 1845 CH3 H H CD3 H H 1846 CH3 H H CH3 H H 1847 CH3 H H H 2,6DIP H 1848 CH3 H H H 2,6DMB H 1849 CH3 H H H CD3 H 1850 CH3 H H H CH3 H 1851 CH3 H H H H 2,6DIP 1852 CH3 H H H H 2,6DMB 1853 CH3 H H H H CD3 1854 CH3 H H H H CH3 1855 CH3 H H H H H 1856 CH3 H H H H iPr 1857 CH3 H H H iPr H 1858 CH3 H H iPr H H 1859 CH3 H ph CD3 H H 1860 CH3 H ph CH3 H H 1861 CH3 H ph H CD3 H 1862 CH3 H ph H CH3 H 1863 CH3 H ph H H CD3 1864 CH3 H ph H H CH3 1865 CH3 H ph H H H 1866 CH3 iPr H H H H 1867 H 2,6DIP H CD3 H H 1868 H 2,6DIP H CH3 H H 1869 H 2,6DIP H H CD3 H 1870 H 2,6DIP H H CH3 H 1871 H 2,6DIP H H H CD3 1872 H 2,6DIP H H H CH3 1873 H 2,6DIP H H H H 1874 H 2,6DMB H CD3 H H 1875 H 2,6DMB H CH3 H H 1876 H 2,6DMB H H CD3 H 1877 H 2,6DMB H H CH3 H 1878 H 2,6DMB H H H CD3 1879 H 2,6DMB H H H CH3 1880 H 2,6DMB H H H H 1881 H CD3 2,6DIP CD3 H H 1882 H CD3 2,6DIP CH3 H H 1883 H CD3 2,6DIP H CD3 H 1884 H CD3 2,6DIP H CH3 H 1885 H CD3 2,6DIP H H CD3 1886 H CD3 2,6DIP H H CH3 1887 H CD3 2,6DIP H H H 1888 H CD3 2,6DIPB CD3 H H 1889 H CD3 2,6DIPB CH3 H H 1890 H CD3 2,6DIPB H CD3 H 1891 H CD3 2,6DIPB H CH3 H 1892 H CD3 2,6DIPB H H CD3 1893 H CD3 2,6DIPB H H CH3 1894 H CD3 2,6DIPB H H H 1895 H CD3 2,6DMB CD3 H H 1896 H CD3 2,6DMB CH3 H H 1897 H CD3 2,6DMB H CD3 H 1898 H CD3 2,6DMB H CH3 H 1899 H CD3 2,6DMB H H CD3 1900 H CD3 2,6DMB H H CH3 1901 H CD3 2,6DMB H H H 1902 H CD3 CD3 CD3 H H 1903 H CD3 CD3 CH3 H H 1904 H CD3 CD3 H CD3 H 1905 H CD3 CD3 H CH3 H 1906 H CD3 CD3 H H CD3 1907 H CD3 CD3 H H CH3 1908 H CD3 CD3 H H H 1909 H CD3 CH3 CD3 H H 1910 H CD3 CH3 CH3 H H 1911 H CD3 CH3 H CD3 H 1912 H CD3 CH3 H CH3 H 1913 H CD3 CH3 H H CD3 1914 H CD3 CH3 H H CH3 1915 H CD3 CH3 H H H 1916 H CD3 H 2,6DIP H H 1917 H CD3 H 2,6DMB H H 1918 H CD3 H CD3 H H 1919 H CD3 H CH3 H H 1920 H CD3 H H 2,6DIP H 1921 H CD3 H H 2,6DMB H 1922 H CD3 H H CD3 H 1923 H CD3 H H CH3 H 1924 H CD3 H H H 2,6DIP 1925 H CD3 H H H 2,6DMB 1926 H CD3 H H H CD3 1927 H CD3 H H H CH3 1928 H CD3 H H H H 1929 H CD3 H H H iPr 1930 H CD3 H H iPr H 1931 H CD3 H iPr H H 1932 H CD3 ph CD3 H H 1933 H CD3 ph CH3 H H 1934 H CD3 ph H CD3 H 1935 H CD3 ph H CH3 H 1936 H CD3 ph H H CD3 1937 H CD3 ph H H CH3 1938 H CD3 ph H H H 1939 H CH3 2,6DIP CD3 H H 1940 H CH3 2,6DIP CH3 H H 1941 H CH3 2,6DIP H CD3 H 1942 H CH3 2,6DIP H CH3 H 1943 H CH3 2,6DIP H H CD3 1944 H CH3 2,6DIP H H CH3 1945 H CH3 2,6DIP H H H 1946 H CH3 2,6DIPB CD3 H H 1947 H CH3 2,6DIPB CH3 H H 1948 H CH3 2,6DIPB H CD3 H 1949 H CH3 2,6DIPB H CH3 H 1950 H CH3 2,6DIPB H H CD3 1951 H CH3 2,6DIPB H H CH3 1952 H CH3 2,6DIPB H H H 1953 H CH3 2,6DMB CD3 H H 1954 H CH3 2,6DMB CH3 H H 1955 H CH3 2,6DMB H CD3 H 1956 H CH3 2,6DMB H CH3 H 1957 H CH3 2,6DMB H H CD3 1958 H CH3 2,6DMB H H CH3 1959 H CH3 2,6DMB H H H 1960 H CH3 CD3 CD3 H H 1961 H CH3 CD3 CH3 H H 1962 H CH3 CD3 H CD3 H 1963 H CH3 CD3 H CH3 H 1964 H CH3 CD3 H H CD3 1965 H CH3 CD3 H H CH3 1966 H CH3 CD3 H H H 1967 H CH3 CH3 CD3 H H 1968 H CH3 CH3 CH3 H H 1969 H CH3 CH3 H CD3 H 1970 H CH3 CH3 H CH3 H 1971 H CH3 CH3 H H CD3 1972 H CH3 CH3 H H CH3 1973 H CH3 CH3 H H H 1974 H CH3 H 2,6DIP H H 1975 H CH3 H 2,6DMB H H 1976 H CH3 H CD3 H H 1977 H CH3 H CH3 H H 1978 H CH3 H H 2,6DIP H 1979 H CH3 H H 2,6DMB H 1980 H CH3 H H CD3 H 1981 H CH3 H H CH3 H 1982 H CH3 H H H 2,6DIP 1983 H CH3 H H H 2,6DMB 1984 H CH3 H H H CD3 1985 H CH3 H H H CH3 1986 H CH3 H H H H 1987 H CH3 H H H iPr 1988 H CH3 H H iPr H 1989 H CH3 H iPr H H 1990 H CH3 ph CD3 H H 1991 H CH3 ph CH3 H H 1992 H CH3 ph H CD3 H 1993 H CH3 ph H CH3 H 1994 H CH3 ph H H CD3 1995 H CH3 ph H H CH3 1996 H CH3 ph H H H 1997 H H 2,6DIP CD3 CD3 H 1998 H H 2,6DIP CD3 CH3 H 1999 H H 2,6DIP CD3 H CD3 2000 H H 2,6DIP CD3 H CH3 2001 H H 2,6DIP CD3 H H 2002 H H 2,6DIP CH3 CD3 H 2003 H H 2,6DIP CH3 CH3 H 2004 H H 2,6DIP CH3 H CD3 2005 H H 2,6DIP CH3 H CH3 2006 H H 2,6DIP CH3 H H 2007 H H 2,6DIP H CD3 CD3 2008 H H 2,6DIP H CD3 CH3 2009 H H 2,6DIP H CD3 H 2010 H H 2,6DIP H CH3 CD3 2011 H H 2,6DIP H CH3 CH3 2012 H H 2,6DIP H CH3 H 2013 H H 2,6DIP H H CD3 2014 H H 2,6DIP H H CH3 2015 H H 2,6DIP H H H 2016 H H 2,6DIPB CD3 CD3 H 2017 H H 2,6DIPB CD3 CH3 H 2018 H H 2,6DIPB CD3 H CD3 2019 H H 2,6DIPB CD3 H CH3 2020 H H 2,6DIPB CD3 H H 2021 H H 2,6DIPB CH3 CD3 H 2022 H H 2,6DIPB CH3 CH3 H 2023 H H 2,6DIPB CH3 H CD3 2024 H H 2,6DIPB CH3 H CH3 2025 H H 2,6DIPB CH3 H H 2026 H H 2,6DIPB H CD3 CD3 2027 H H 2,6DIPB H CD3 CH3 2028 H H 2,6DIPB H CD3 H 2029 H H 2,6DIPB H CH3 CD3 2030 H H 2,6DIPB H CH3 CH3 2031 H H 2,6DIPB H CH3 H 2032 H H 2,6DIPB H H CD3 2033 H H 2,6DIPB H H CH3 2034 H H 2,6DIPB H H H 2035 H H 2,6DMB CD3 CD3 H 2036 H H 2,6DMB CD3 CH3 H 2037 H H 2,6DMB CD3 H CD3 2038 H H 2,6DMB CD3 H CH3 2039 H H 2,6DMB CD3 H H 2040 H H 2,6DMB CH3 CD3 H 2041 H H 2,6DMB CH3 CH3 H 2042 H H 2,6DMB CH3 H CD3 2043 H H 2,6DMB CH3 H CH3 2044 H H 2,6DMB CH3 H H 2045 H H 2,6DMB H CD3 CD3 2046 H H 2,6DMB H CD3 CH3 2047 H H 2,6DMB H CD3 H 2048 H H 2,6DMB H CH3 CD3 2049 H H 2,6DMB H CH3 CH3 2050 H H 2,6DMB H CH3 H 2051 H H 2,6DMB H H CD3 2052 H H 2,6DMB H H CH3 2053 H H 2,6DMB H H H 2054 H H CD3 CD3 CD3 H 2055 H H CD3 CD3 CH3 H 2056 H H CD3 CD3 H CD3 2057 H H CD3 CD3 H CH3 2058 H H CD3 CD3 H H 2059 H H CD3 CH3 CD3 H 2060 H H CD3 CH3 CH3 H 2061 H H CD3 CH3 H CD3 2062 H H CD3 CH3 H CH3 2063 H H CD3 CH3 H H 2064 H H CD3 H 2,6DIP H 2065 H H CD3 H 2,6DMB H 2066 H H CD3 H CD3 CD3 2067 H H CD3 H CD3 CH3 2068 H H CD3 H CD3 H 2069 H H CD3 H CH3 CD3 2070 H H CD3 H CH3 CH3 2071 H H CD3 H CH3 H 2072 H H CD3 H H 2,6DIP 2073 H H CD3 H H 2,6DMB 2074 H H CD3 H H CD3 2075 H H CD3 H H CH3 2076 H H CD3 H H H 2077 H H CD3 H H iPr 2078 H H CD3 H iPr H 2079 H H CD3 iPr H H 2080 H H CH3 CD3 CD3 H 2081 H H CH3 CD3 CH3 H 2082 H H CH3 CD3 H CD3 2083 H H CH3 CD3 H CH3 2084 H H CH3 CD3 H H 2085 H H CH3 CH3 CD3 H 2086 H H CH3 CH3 CH3 H 2087 H H CH3 CH3 H CD3 2088 H H CH3 CH3 H CH3 2089 H H CH3 CH3 H H 2090 H H CH3 H 2,6DIP H 2091 H H CH3 H 2,6DMB H 2092 H H CH3 H CD3 CD3 2093 H H CH3 H CD3 CH3 2094 H H CH3 H CD3 H 2095 H H CH3 H CH3 CD3 2096 H H CH3 H CH3 CH3 2097 H H CH3 H CH3 H 2098 H H CH3 H H 2,6DIP 2099 H H CH3 H H 2,6DMB 2100 H H CH3 H H CD3 2101 H H CH3 H H CH3 2102 H H CH3 H H H 2103 H H CH3 H H iPr 2104 H H CH3 H iPr H 2105 H H CH3 iPr H H 2106 H H H 2,6DIP H CD3 2107 H H H 2,6DIP H CH3 2108 H H H 2,6DIP H H 2109 H H H 2,6DMB H CD3 2110 H H H 2,6DMB H CH3 2111 H H H 2,6DMB H H 2112 H H H CD3 CD3 H 2113 H H H CD3 CH3 H 2114 H H H CD3 H 2,6DIP 2115 H H H CD3 H 2,6DMB 2116 H H H CD3 H CD3 2117 H H H CD3 H CH3 2118 H H H CD3 H H 2119 H H H CD3 H iPr 2120 H H H CD3 iPr H 2121 H H H CH3 CD3 H 2122 H H H CH3 CH3 H 2123 H H H CH3 H 2,6DIP 2124 H H H CH3 H 2,6DMB 2125 H H H CH3 H CD3 2126 H H H CH3 H CH3 2127 H H H CH3 H H 2128 H H H CH3 H iPr 2129 H H H CH3 iPr H 2130 H H H H 2,6DIP CD3 2131 H H H H 2,6DIP CH3 2132 H H H H 2,6DIP H 2133 H H H H 2,6DMB CD3 2134 H H H H 2,6DMB CH3 2135 H H H H 2,6DMB H 2136 H H H H CD3 2,6DIP 2137 H H H H CD3 2,6DMB 2138 H H H H CD3 CD3 2139 H H H H CD3 CH3 2140 H H H H CD3 H 2141 H H H H CD3 iPr 2142 H H H H CH3 2,6DIP 2143 H H H H CH3 2,6DMB 2144 H H H H CH3 CD3 2145 H H H H CH3 CH3 2146 H H H H CH3 H 2147 H H H H CH3 iPr 2148 H H H H H 2,6DIP 2149 H H H H H 2,6DMB 2150 H H H H H CD3 2151 H H H H H CH3 2152 H H H H H H 2153 H H H H H iPr 2154 H H H H iPr CD3 2155 H H H H iPr CH3 2156 H H H H iPr H 2157 H H H iPr CD3 H 2158 H H H iPr CH3 H 2159 H H H iPr H CD3 2160 H H H iPr H CH3 2161 H H H iPr H H 2162 H H ph CD3 CD3 H 2163 H H ph CD3 CH3 H 2164 H H ph CD3 H CD3 2165 H H ph CD3 H CH3 2166 H H ph CD3 H H 2167 H H ph CH3 CD3 H 2168 H H ph CH3 CH3 H 2169 H H ph CH3 H CD3 2170 H H ph CH3 H CH3 2171 H H ph CH3 H H 2172 H H ph H CD3 CD3 2173 H H ph H CD3 CH3 2174 H H ph H CD3 H 2175 H H ph H CH3 CD3 2176 H H ph H CH3 CH3 2177 H H ph H CH3 H 2178 H H ph H H CD3 2179 H H ph H H CH3 2180 H H ph H H H 2181 H iPr CD3 H H H 2182 H iPr CH3 H H H 2183 H iPr H CD3 H H 2184 H iPr H CH3 H H 2185 H iPr H H CD3 H 2186 H iPr H H CH3 H 2187 H iPr H H H CD3 2188 H iPr H H H CH3 2189 H iPr H H H H 2190 iPr CD3 H H H H 2191 iPr CH3 H H H H 2192 iPr H CD3 H H H 2193 iPr H CH3 H H H 2194 iPr H H CD3 H H 2195 iPr H H CH3 H H 2196 iPr H H H CD3 H 2197 iPr H H H CH3 H 2198 iPr H H H H CD3 2199 iPr H H H H CH3 2200 iPr H H H H H LA2201 to LA2680 based on structure:

LA # R11 R12 R2 R31 R33 R34 2201 CD3 CD3 2,6DIP H H H 2202 CD3 CD3 2,6DIPB H H H 2203 CD3 CD3 2,6DMB H H H 2204 CD3 CD3 CD3 H H H 2205 CD3 CD3 CH3 H H H 2206 CD3 CD3 H H H H 2207 CD3 CD3 ph H H H 2208 CD3 CH3 2,6DIP H H H 2209 CD3 CH3 2,6DIPB H H H 2210 CD3 CH3 2,6DMB H H H 2211 CD3 CH3 CD3 H H H 2212 CD3 CH3 CH3 H H H 2213 CD3 CH3 H H H H 2214 CD3 CH3 ph H H H 2215 CD3 H 2,6DIP CD3 H H 2216 CD3 H 2,6DIP CH3 H H 2217 CD3 H 2,6DIP H CD3 H 2218 CD3 H 2,6DIP H CH3 H 2219 CD3 H 2,6DIP H H CD3 2220 CD3 H 2,6DIP H H CH3 2221 CD3 H 2,6DIP H H H 2222 CD3 H 2,6DIPB CD3 H H 2223 CD3 H 2,6DIPB CH3 H H 2224 CD3 H 2,6DIPB H CD3 H 2225 CD3 H 2,6DIPB H CH3 H 2226 CD3 H 2,6DIPB H H CD3 2227 CD3 H 2,6DIPB H H CH3 2228 CD3 H 2,6DIPB H H H 2229 CD3 H 2,6DMB CD3 H H 2230 CD3 H 2,6DMB CH3 H H 2231 CD3 H 2,6DMB H CD3 H 2232 CD3 H 2,6DMB H CH3 H 2233 CD3 H 2,6DMB H H CD3 2234 CD3 H 2,6DMB H H CH3 2235 CD3 H 2,6DMB H H H 2236 CD3 H CD3 CD3 H H 2237 CD3 H CD3 CH3 H H 2238 CD3 H CD3 H CD3 H 2239 CD3 H CD3 H CH3 H 2240 CD3 H CD3 H H CD3 2241 CD3 H CD3 H H CH3 2242 CD3 H CD3 H H H 2243 CD3 H CH3 CD3 H H 2244 CD3 H CH3 CH3 H H 2245 CD3 H CH3 H CD3 H 2246 CD3 H CH3 H CH3 H 2247 CD3 H CH3 H H CD3 2248 CD3 H CH3 H H CH3 2249 CD3 H CH3 H H H 2250 CD3 H H 2,6DIP H H 2251 CD3 H H 2,6DMB H H 2252 CD3 H H CD3 H H 2253 CD3 H H CH3 H H 2254 CD3 H H H 2,6DIP H 2255 CD3 H H H 2,6DMB H 2256 CD3 H H H CD3 H 2257 CD3 H H H CH3 H 2258 CD3 H H H H 2,6DIP 2259 CD3 H H H H 2,6DMB 2260 CD3 H H H H CD3 2261 CD3 H H H H CH3 2262 CD3 H H H H H 2263 CD3 H H H H iPr 2264 CD3 H H H iPr H 2265 CD3 H H iPr H H 2266 CD3 H ph CD3 H H 2267 CD3 H ph CH3 H H 2268 CD3 H ph H CD3 H 2269 CD3 H ph H CH3 H 2270 CD3 H ph H H CD3 2271 CD3 H ph H H CH3 2272 CD3 H ph H H H 2273 CD3 iPr H H H H 2274 CH3 CD3 2,6DIP H H H 2275 CH3 CD3 2,6DIPB H H H 2276 CH3 CD3 2,6DMB H H H 2277 CH3 CD3 CD3 H H H 2278 CH3 CD3 CH3 H H H 2279 CH3 CD3 H H H H 2280 CH3 CD3 ph H H H 2281 CH3 CH3 2,6DIP H H H 2282 CH3 CH3 2,6DIPB H H H 2283 CH3 CH3 2,6DMB H H H 2284 CH3 CH3 CD3 H H H 2285 CH3 CH3 CH3 H H H 2286 CH3 CH3 H H H H 2287 CH3 CH3 ph H H H 2288 CH3 H 2,6DIP CD3 H H 2289 CH3 H 2,6DIP CH3 H H 2290 CH3 H 2,6DIP H CD3 H 2291 CH3 H 2,6DIP H CH3 H 2292 CH3 H 2,6DIP H H CD3 2293 CH3 H 2,6DIP H H CH3 2294 CH3 H 2,6DIP H H H 2295 CH3 H 2,6DIPB CD3 H H 2296 CH3 H 2,6DIPB CH3 H H 2297 CH3 H 2,6DIPB H CD3 H 2298 CH3 H 2,6DIPB H CH3 H 2299 CH3 H 2,6DIPB H H CD3 2300 CH3 H 2,6DIPB H H CH3 2301 CH3 H 2,6DIPB H H H 2302 CH3 H 2,6DMB CD3 H H 2303 CH3 H 2,6DMB CH3 H H 2304 CH3 H 2,6DMB H CD3 H 2305 CH3 H 2,6DMB H CH3 H 2306 CH3 H 2,6DMB H H CD3 2307 CH3 H 2,6DMB H H CH3 2308 CH3 H 2,6DMB H H H 2309 CH3 H CD3 CD3 H H 2310 CH3 H CD3 CH3 H H 2311 CH3 H CD3 H CD3 H 2312 CH3 H CD3 H CH3 H 2313 CH3 H CD3 H H CD3 2314 CH3 H CD3 H H CH3 2315 CH3 H CD3 H H H 2316 CH3 H CH3 CD3 H H 2317 CH3 H CH3 CH3 H H 2318 CH3 H CH3 H CD3 H 2319 CH3 H CH3 H CH3 H 2320 CH3 H CH3 H H CD3 2321 CH3 H CH3 H H CH3 2322 CH3 H CH3 H H H 2323 CH3 H H 2,6DIP H H 2324 CH3 H H 2,6DMB H H 2325 CH3 H H CD3 H H 2326 CH3 H H CH3 H H 2327 CH3 H H H 2,6DIP H 2328 CH3 H H H 2,6DMB H 2329 CH3 H H H CD3 H 2330 CH3 H H H CH3 H 2331 CH3 H H H H 2,6DIP 2332 CH3 H H H H 2,6DMB 2333 CH3 H H H H CD3 2334 CH3 H H H H CH3 2335 CH3 H H H H H 2336 CH3 H H H H iPr 2337 CH3 H H H iPr H 2338 CH3 H H iPr H H 2339 CH3 H ph CD3 H H 2340 CH3 H ph CH3 H H 2341 CH3 H ph H CD3 H 2342 CH3 H ph H CH3 H 2343 CH3 H ph H H CD3 2344 CH3 H ph H H CH3 2345 CH3 H ph H H H 2346 CH3 iPr H H H H 2347 H 2,6DIP H CD3 H H 2348 H 2,6DIP H CH3 H H 2349 H 2,6DIP H H CD3 H 2350 H 2,6DIP H H CH3 H 2351 H 2,6DIP H H H CD3 2352 H 2,6DIP H H H CH3 2353 H 2,6DIP H H H H 2354 H 2,6DMB H CD3 H H 2355 H 2,6DMB H CH3 H H 2356 H 2,6DMB H H CD3 H 2357 H 2,6DMB H H CH3 H 2358 H 2,6DMB H H H CD3 2359 H 2,6DMB H H H CH3 2360 H 2,6DMB H H H H 2361 H CD3 2,6DIP CD3 H H 2362 H CD3 2,6DIP CH3 H H 2363 H CD3 2,6DIP H CD3 H 2364 H CD3 2,6DIP H CH3 H 2365 H CD3 2,6DIP H H CD3 2366 H CD3 2,6DIP H H CH3 2367 H CD3 2,6DIP H H H 2368 H CD3 2,6DIPB CD3 H H 2369 H CD3 2,6DIPB CH3 H H 2370 H CD3 2,6DIPB H CD3 H 2371 H CD3 2,6DIPB H CH3 H 2372 H CD3 2,6DIPB H H CD3 2373 H CD3 2,6DIPB H H CH3 2374 H CD3 2,6DIPB H H H 2375 H CD3 2,6DMB CD3 H H 2376 H CD3 2,6DMB CH3 H H 2377 H CD3 2,6DMB H CD3 H 2378 H CD3 2,6DMB H CH3 H 2379 H CD3 2,6DMB H H CD3 2380 H CD3 2,6DMB H H CH3 2381 H CD3 2,6DMB H H H 2382 H CD3 CD3 CD3 H H 2383 H CD3 CD3 CH3 H H 2384 H CD3 CD3 H CD3 H 2385 H CD3 CD3 H CH3 H 2386 H CD3 CD3 H H CD3 2387 H CD3 CD3 H H CH3 2388 H CD3 CD3 H H H 2389 H CD3 CH3 CD3 H H 2390 H CD3 CH3 CH3 H H 2391 H CD3 CH3 H CD3 H 2392 H CD3 CH3 H CH3 H 2393 H CD3 CH3 H H CD3 2394 H CD3 CH3 H H CH3 2395 H CD3 CH3 H H H 2396 H CD3 H 2,6DIP H H 2397 H CD3 H 2,6DMB H H 2398 H CD3 H CD3 H H 2399 H CD3 H CH3 H H 2400 H CD3 H H 2,6DIP H 2401 H CD3 H H 2,6DMB H 2402 H CD3 H H CD3 H 2403 H CD3 H H CH3 H 2404 H CD3 H H H 2,6DIP 2405 H CD3 H H H 2,6DMB 2406 H CD3 H H H CD3 2407 H CD3 H H H CH3 2408 H CD3 H H H H 2409 H CD3 H H H iPr 2410 H CD3 H H iPr H 2411 H CD3 H iPr H H 2412 H CD3 ph CD3 H H 2413 H CD3 ph CH3 H H 2414 H CD3 ph H CD3 H 2415 H CD3 ph H CH3 H 2416 H CD3 ph H H CD3 2417 H CD3 ph H H CH3 2418 H CD3 ph H H H 2419 H CH3 2,6DIP CD3 H H 2420 H CH3 2,6DIP CH3 H H 2421 H CH3 2,6DIP H CD3 H 2422 H CH3 2,6DIP H CH3 H 2423 H CH3 2,6DIP H H CD3 2424 H CH3 2,6DIP H H CH3 2425 H CH3 2,6DIP H H H 2426 H CH3 2,6DIPB CD3 H H 2427 H CH3 2,6DIPB CH3 H H 2428 H CH3 2,6DIPB H CD3 H 2429 H CH3 2,6DIPB H CH3 H 2430 H CH3 2,6DIPB H H CD3 2431 H CH3 2,6DIPB H H CH3 2432 H CH3 2,6DIPB H H H 2433 H CH3 2,6DMB CD3 H H 2434 H CH3 2,6DMB CH3 H H 2435 H CH3 2,6DMB H CD3 H 2436 H CH3 2,6DMB H CH3 H 2437 H CH3 2,6DMB H H CD3 2438 H CH3 2,6DMB H H CH3 2439 H CH3 2,6DMB H H H 2440 H CH3 CD3 CD3 H H 2441 H CH3 CD3 CH3 H H 2442 H CH3 CD3 H CD3 H 2443 H CH3 CD3 H CH3 H 2444 H CH3 CD3 H H CD3 2445 H CH3 CD3 H H CH3 2446 H CH3 CD3 H H H 2447 H CH3 CH3 CD3 H H 2448 H CH3 CH3 CH3 H H 2449 H CH3 CH3 H CD3 H 2450 H CH3 CH3 H CH3 H 2451 H CH3 CH3 H H CD3 2452 H CH3 CH3 H H CH3 2453 H CH3 CH3 H H H 2454 H CH3 H 2,6DIP H H 2455 H CH3 H 2,6DMB H H 2456 H CH3 H CD3 H H 2457 H CH3 H CH3 H H 2458 H CH3 H H 2,6DIP H 2459 H CH3 H H 2,6DMB H 2460 H CH3 H H CD3 H 2461 H CH3 H H CH3 H 2462 H CH3 H H H 2,6DIP 2463 H CH3 H H H 2,6DMB 2464 H CH3 H H H CD3 2465 H CH3 H H H CH3 2466 H CH3 H H H H 2467 H CH3 H H H iPr 2468 H CH3 H H iPr H 2469 H CH3 H iPr H H 2470 H CH3 ph CD3 H H 2471 H CH3 ph CH3 H H 2472 H CH3 ph H CD3 H 2473 H CH3 ph H CH3 H 2474 H CH3 ph H H CD3 2475 H CH3 ph H H CH3 2476 H CH3 ph H H H 2477 H H 2,6DIP CD3 CD3 H 2478 H H 2,6DIP CD3 CH3 H 2479 H H 2,6DIP CD3 H CD3 2480 H H 2,6DIP CD3 H CH3 2481 H H 2,6DIP CD3 H H 2482 H H 2,6DIP CH3 CD3 H 2483 H H 2,6DIP CH3 CH3 H 2484 H H 2,6DIP CH3 H CD3 2485 H H 2,6DIP CH3 H CH3 2486 H H 2,6DIP CH3 H H 2487 H H 2,6DIP H CD3 CD3 2488 H H 2,6DIP H CD3 CH3 2489 H H 2,6DIP H CD3 H 2490 H H 2,6DIP H CH3 CD3 2491 H H 2,6DIP H CH3 CH3 2492 H H 2,6DIP H CH3 H 2493 H H 2,6DIP H H CD3 2494 H H 2,6DIP H H CH3 2495 H H 2,6DIP H H H 2496 H H 2,6DIPB CD3 CD3 H 2497 H H 2,6DIPB CD3 CH3 H 2498 H H 2,6DIPB CD3 H CD3 2499 H H 2,6DIPB CD3 H CH3 2500 H H 2,6DIPB CD3 H H 2501 H H 2,6DIPB CH3 CD3 H 2502 H H 2,6DIPB CH3 CH3 H 2503 H H 2,6DIPB CH3 H CD3 2504 H H 2,6DIPB CH3 H CH3 2505 H H 2,6DIPB CH3 H H 2506 H H 2,6DIPB H CD3 CD3 2507 H H 2,6DIPB H CD3 CH3 2508 H H 2,6DIPB H CD3 H 2509 H H 2,6DIPB H CH3 CD3 2510 H H 2,6DIPB H CH3 CH3 2511 H H 2,6DIPB H CH3 H 2512 H H 2,6DIPB H H CD3 2513 H H 2,6DIPB H H CH3 2514 H H 2,6DIPB H H H 2515 H H 2,6DMB CD3 CD3 H 2516 H H 2,6DMB CD3 CH3 H 2517 H H 2,6DMB CD3 H CD3 2518 H H 2,6DMB CD3 H CH3 2519 H H 2,6DMB CD3 H H 2520 H H 2,6DMB CH3 CD3 H 2521 H H 2,6DMB CH3 CH3 H 2522 H H 2,6DMB CH3 H CD3 2523 H H 2,6DMB CH3 H CH3 2524 H H 2,6DMB CH3 H H 2525 H H 2,6DMB H CD3 CD3 2526 H H 2,6DMB H CD3 CH3 2527 H H 2,6DMB H CD3 H 2528 H H 2,6DMB H CH3 CD3 2529 H H 2,6DMB H CH3 CH3 2530 H H 2,6DMB H CH3 H 2531 H H 2,6DMB H H CD3 2532 H H 2,6DMB H H CH3 2533 H H 2,6DMB H H H 2534 H H CD3 CD3 CD3 H 2535 H H CD3 CD3 CH3 H 2536 H H CD3 CD3 H CD3 2537 H H CD3 CD3 H CH3 2538 H H CD3 CD3 H H 2539 H H CD3 CH3 CD3 H 2540 H H CD3 CH3 CH3 H 2541 H H CD3 CH3 H CD3 2542 H H CD3 CH3 H CH3 2543 H H CD3 CH3 H H 2544 H H CD3 H 2,6DIP H 2545 H H CD3 H 2,6DMB H 2546 H H CD3 H CD3 CD3 2547 H H CD3 H CD3 CH3 2548 H H CD3 H CD3 H 2549 H H CD3 H CH3 CD3 2550 H H CD3 H CH3 CH3 2551 H H CD3 H CH3 H 2552 H H CD3 H H 2,6DIP 2553 H H CD3 H H 2,6DMB 2554 H H CD3 H H CD3 2555 H H CD3 H H CH3 2556 H H CD3 H H H 2557 H H CD3 H H iPr 2558 H H CD3 H iPr H 2559 H H CD3 iPr H H 2560 H H CH3 CD3 CD3 H 2561 H H CH3 CD3 CH3 H 2562 H H CH3 CD3 H CD3 2563 H H CH3 CD3 H CH3 2564 H H CH3 CD3 H H 2565 H H CH3 CH3 CD3 H 2566 H H CH3 CH3 CH3 H 2567 H H CH3 CH3 H CD3 2568 H H CH3 CH3 H CH3 2569 H H CH3 CH3 H H 2570 H H CH3 H 2,6DIP H 2571 H H CH3 H 2,6DMB H 2572 H H CH3 H CD3 CD3 2573 H H CH3 H CD3 CH3 2574 H H CH3 H CD3 H 2575 H H CH3 H CH3 CD3 2576 H H CH3 H CH3 CH3 2577 H H CH3 H CH3 H 2578 H H CH3 H H 2,6DIP 2579 H H CH3 H H 2,6DMB 2580 H H CH3 H H CD3 2581 H H CH3 H H CH3 2582 H H CH3 H H H 2583 H H CH3 H H iPr 2584 H H CH3 H iPr H 2585 H H CH3 iPr H H 2586 H H H 2,6DIP CD3 H 2587 H H H 2,6DIP CH3 H 2588 H H H 2,6DIP H CD3 2589 H H H 2,6DIP H CH3 2590 H H H 2,6DIP H H 2591 H H H 2,6DMB CD3 H 2592 H H H 2,6DMB CH3 H 2593 H H H 2,6DMB H CD3 2594 H H H 2,6DMB H CH3 2595 H H H 2,6DMB H H 2596 H H H CD3 2,6DIP H 2597 H H H CD3 2,6DMB H 2598 H H H CD3 CD3 H 2599 H H H CD3 CH3 H 2600 H H H CD3 H 2,6DIP 2601 H H H CD3 H 2,6DMB 2602 H H H CD3 H CD3 2603 H H H CD3 H CH3 2604 H H H CD3 H H 2605 H H H CD3 H iPr 2606 H H H CD3 iPr H 2607 H H H CH3 2,6DIP H 2608 H H H CH3 2,6DMB H 2609 H H H CH3 CD3 H 2610 H H H CH3 CH3 H 2611 H H H CH3 H 2,6DIP 2612 H H H CH3 H 2,6DMB 2613 H H H CH3 H CD3 2614 H H H CH3 H CH3 2615 H H H CH3 H H 2616 H H H CH3 H iPr 2617 H H H CH3 iPr H 2618 H H H H 2,6DIP H 2619 H H H H 2,6DMB H 2620 H H H H CD3 CD3 2621 H H H H CD3 CH3 2622 H H H H CD3 H 2623 H H H H CD3 iPr 2624 H H H H CH3 CD3 2625 H H H H CH3 CH3 2626 H H H H CH3 H 2627 H H H H CH3 iPr 2628 H H H H H 2,6DIP 2629 H H H H H 2,6DMB 2630 H H H H H CD3 2631 H H H H H CH3 2632 H H H H H H 2633 H H H H H iPr 2634 H H H H iPr CD3 2635 H H H H iPr CH3 2636 H H H H iPr H 2637 H H H iPr CD3 H 2638 H H H iPr CH3 H 2639 H H H iPr H CD3 2640 H H H iPr H CH3 2641 H H H iPr H H 2642 H H ph CD3 CD3 H 2643 H H ph CD3 CH3 H 2644 H H ph CD3 H CD3 2645 H H ph CD3 H CH3 2646 H H ph CD3 H H 2647 H H ph CH3 CD3 H 2648 H H ph CH3 CH3 H 2649 H H ph CH3 H CD3 2650 H H ph CH3 H CH3 2651 H H ph CH3 H H 2652 H H ph H CD3 CD3 2653 H H ph H CD3 CH3 2654 H H ph H CD3 H 2655 H H ph H CH3 CD3 2656 H H ph H CH3 CH3 2657 H H ph H CH3 H 2658 H H ph H H CD3 2659 H H ph H H CH3 2660 H H ph H H H 2661 H iPr CD3 H H H 2662 H iPr CH3 H H H 2663 H iPr H CD3 H H 2664 H iPr H CH3 H H 2665 H iPr H H CD3 H 2666 H iPr H H CH3 H 2667 H iPr H H H CD3 2668 H iPr H H H CH3 2669 H iPr H H H H 2670 iPr CD3 H H H H 2671 iPr CH3 H H H H 2672 iPr H CD3 H H H 2673 iPr H CH3 H H H 2674 iPr H H CD3 H H 2675 iPr H H CH3 H H 2676 iPr H H H CD3 H 2677 iPr H H H CH3 H 2678 iPr H H H H CD3 2679 iPr H H H H CH3 2680 iPr H H H H H LA2681 to LA3156 based on structure:

LA # R11 R12 R2 R32 R33 R34 2681 CD3 CD3 2,6DIP H H H 2682 CD3 CD3 2,6DIPB H H H 2683 CD3 CD3 2,6DMB H H H 2684 CD3 CD3 CD3 H H H 2685 CD3 CD3 CH3 H H H 2686 CD3 CD3 H H H H 2687 CD3 CD3 ph H H H 2688 CD3 CH3 2,6DIP H H H 2689 CD3 CH3 2,6DIPB H H H 2690 CD3 CH3 2,6DMB H H H 2691 CD3 CH3 CD3 H H H 2692 CD3 CH3 CH3 H H H 2693 CD3 CH3 H H H H 2694 CD3 CH3 ph H H H 2695 CD3 H 2,6DIP CD3 H H 2696 CD3 H 2,6DIP CH3 H H 2697 CD3 H 2,6DIP H CD3 H 2698 CD3 H 2,6DIP H CH3 H 2699 CD3 H 2,6DIP H H CD3 2700 CD3 H 2,6DIP H H CH3 2701 CD3 H 2,6DIP H H H 2702 CD3 H 2,6DIPB CD3 H H 2703 CD3 H 2,6DIPB CH3 H H 2704 CD3 H 2,6DIPB H CD3 H 2705 CD3 H 2,6DIPB H CH3 H 2706 CD3 H 2,6DIPB H H CD3 2707 CD3 H 2,6DIPB H H CH3 2708 CD3 H 2,6DIPB H H H 2709 CD3 H 2,6DMB CD3 H H 2710 CD3 H 2,6DMB CH3 H H 2711 CD3 H 2,6DMB H CD3 H 2712 CD3 H 2,6DMB H CH3 H 2713 CD3 H 2,6DMB H H CD3 2714 CD3 H 2,6DMB H H CH3 2715 CD3 H 2,6DMB H H H 2716 CD3 H CD3 CD3 H H 2717 CD3 H CD3 CH3 H H 2718 CD3 H CD3 H CD3 H 2719 CD3 H CD3 H CH3 H 2720 CD3 H CD3 H H CD3 2721 CD3 H CD3 H H CH3 2722 CD3 H CD3 H H H 2723 CD3 H CH3 CD3 H H 2724 CD3 H CH3 CH3 H H 2725 CD3 H CH3 H CD3 H 2726 CD3 H CH3 H CH3 H 2727 CD3 H CH3 H H CD3 2728 CD3 H CH3 H H CH3 2729 CD3 H CH3 H H H 2730 CD3 H H 2,6DIP H H 2731 CD3 H H 2,6DMB H H 2732 CD3 H H CD3 H H 2733 CD3 H H CH3 H H 2734 CD3 H H H 2,6DIP H 2735 CD3 H H H 2,6DMB H 2736 CD3 H H H CD3 H 2737 CD3 H H H CH3 H 2738 CD3 H H H H 2,6DIP 2739 CD3 H H H H 2,6DMB 2740 CD3 H H H H CD3 2741 CD3 H H H H CH3 2742 CD3 H H H H H 2743 CD3 H H H H iPr 2744 CD3 H H H iPr H 2745 CD3 H H iPr H H 2746 CD3 H ph CD3 H H 2747 CD3 H ph CH3 H H 2748 CD3 H ph H CD3 H 2749 CD3 H ph H CH3 H 2750 CD3 H ph H H CD3 2751 CD3 H ph H H CH3 2752 CD3 H ph H H H 2753 CD3 iPr H H H H 2754 CH3 CD3 2,6DIP H H H 2755 CH3 CD3 2,6DIPB H H H 2756 CH3 CD3 2,6DMB H H H 2757 CH3 CD3 CD3 H H H 2758 CH3 CD3 CH3 H H H 2759 CH3 CD3 H H H H 2760 CH3 CD3 ph H H H 2761 CH3 CH3 2,6DIP H H H 2762 CH3 CH3 2,6DIPB H H H 2763 CH3 CH3 2,6DMB H H H 2764 CH3 CH3 CD3 H H H 2765 CH3 CH3 CH3 H H H 2766 CH3 CH3 H H H H 2767 CH3 CH3 ph H H H 2768 CH3 H 2,6DIP CD3 H H 2769 CH3 H 2,6DIP CH3 H H 2770 CH3 H 2,6DIP H CD3 H 2771 CH3 H 2,6DIP H CH3 H 2772 CH3 H 2,6DIP H H CD3 2773 CH3 H 2,6DIP H H CH3 2774 CH3 H 2,6DIP H H H 2775 CH3 H 2,6DIPB CD3 H H 2776 CH3 H 2,6DIPB CH3 H H 2777 CH3 H 2,6DIPB H CD3 H 2778 CH3 H 2,6DIPB H CH3 H 2779 CH3 H 2,6DIPB H H CD3 2780 CH3 H 2,6DIPB H H CH3 2781 CH3 H 2,6DIPB H H H 2782 CH3 H 2,6DMB CD3 H H 2783 CH3 H 2,6DMB CH3 H H 2784 CH3 H 2,6DMB H CD3 H 2785 CH3 H 2,6DMB H CH3 H 2786 CH3 H 2,6DMB H H CD3 2787 CH3 H 2,6DMB H H CH3 2788 CH3 H 2,6DMB H H H 2789 CH3 H CD3 CD3 H H 2790 CH3 H CD3 CH3 H H 2791 CH3 H CD3 H CD3 H 2792 CH3 H CD3 H CH3 H 2793 CH3 H CD3 H H CD3 2794 CH3 H CD3 H H CH3 2795 CH3 H CD3 H H H 2796 CH3 H CH3 CD3 H H 2797 CH3 H CH3 CH3 H H 2798 CH3 H CH3 H CD3 H 2799 CH3 H CH3 H CH3 H 2800 CH3 H CH3 H H CD3 2801 CH3 H CH3 H H CH3 2802 CH3 H CH3 H H H 2803 CH3 H H 2,6DIP H H 2804 CH3 H H 2,6DMB H H 2805 CH3 H H CD3 H H 2806 CH3 H H CH3 H H 2807 CH3 H H H 2,6DIP H 2808 CH3 H H H 2,6DMB H 2809 CH3 H H H CD3 H 2810 CH3 H H H CH3 H 2811 CH3 H H H H 2,6DIP 2812 CH3 H H H H 2,6DMB 2813 CH3 H H H H CD3 2814 CH3 H H H H CH3 2815 CH3 H H H H H 2816 CH3 H H H H iPr 2817 CH3 H H H iPr H 2818 CH3 H H iPr H H 2819 CH3 H ph CD3 H H 2820 CH3 H ph CH3 H H 2821 CH3 H ph H CD3 H 2822 CH3 H ph H CH3 H 2823 CH3 H ph H H CD3 2824 CH3 H ph H H CH3 2825 CH3 H ph H H H 2826 CH3 iPr H H H H 2827 H 2,6DIP H CD3 H H 2828 H 2,6DIP H CH3 H H 2829 H 2,6DIP H H CD3 H 2830 H 2,6DIP H H CH3 H 2831 H 2,6DIP H H H CD3 2832 H 2,6DIP H H H CH3 2833 H 2,6DIP H H H H 2834 H 2,6DMB H CD3 H H 2835 H 2,6DMB H CH3 H H 2836 H 2,6DMB H H CD3 H 2837 H 2,6DMB H H CH3 H 2838 H 2,6DMB H H H CD3 2839 H 2,6DMB H H H CH3 2840 H 2,6DMB H H H H 2841 H CD3 2,6DIP CD3 H H 2842 H CD3 2,6DIP CH3 H H 2843 H CD3 2,6DIP H CD3 H 2844 H CD3 2,6DIP H CH3 H 2845 H CD3 2,6DIP H H CD3 2846 H CD3 2,6DIP H H CH3 2847 H CD3 2,6DIP H H H 2848 H CD3 2,6DIPB CD3 H H 2849 H CD3 2,6DIPB CH3 H H 2850 H CD3 2,6DIPB H CD3 H 2851 H CD3 2,6DIPB H CH3 H 2852 H CD3 2,6DIPB H H CD3 2853 H CD3 2,6DIPB H H CH3 2854 H CD3 2,6DIPB H H H 2855 H CD3 2,6DMB CD3 H H 2856 H CD3 2,6DMB CH3 H H 2857 H CD3 2,6DMB H CD3 H 2858 H CD3 2,6DMB H CH3 H 2859 H CD3 2,6DMB H H CD3 2860 H CD3 2,6DMB H H CH3 2861 H CD3 2,6DMB H H H 2862 H CD3 CD3 CD3 H H 2863 H CD3 CD3 CH3 H H 2864 H CD3 CD3 H CD3 H 2865 H CD3 CD3 H CH3 H 2866 H CD3 CD3 H H CD3 2867 H CD3 CD3 H H CH3 2868 H CD3 CD3 H H H 2869 H CD3 CH3 CD3 H H 2870 H CD3 CH3 CH3 H H 2871 H CD3 CH3 H CD3 H 2872 H CD3 CH3 H CH3 H 2873 H CD3 CH3 H H CD3 2874 H CD3 CH3 H H CH3 2875 H CD3 CH3 H H H 2876 H CD3 H 2,6DIP H H 2877 H CD3 H 2,6DMB H H 2878 H CD3 H CD3 H H 2879 H CD3 H CH3 H H 2880 H CD3 H H 2,6DIP H 2881 H CD3 H H 2,6DMB H 2882 H CD3 H H CD3 H 2883 H CD3 H H CH3 H 2884 H CD3 H H H 2,6DIP 2885 H CD3 H H H 2,6DMB 2886 H CD3 H H H CD3 2887 H CD3 H H H CH3 2888 H CD3 H H H H 2889 H CD3 H H H iPr 2890 H CD3 H H iPr H 2891 H CD3 H iPr H H 2892 H CD3 ph CD3 H H 2893 H CD3 ph CH3 H H 2894 H CD3 ph H CD3 H 2895 H CD3 ph H CH3 H 2896 H CD3 ph H H CD3 2897 H CD3 ph H H CH3 2898 H CD3 ph H H H 2899 H CH3 2,6DIP CD3 H H 2900 H CH3 2,6DIP CH3 H H 2901 H CH3 2,6DIP H CD3 H 2902 H CH3 2,6DIP H CH3 H 2903 H CH3 2,6DIP H H CD3 2904 H CH3 2,6DIP H H CH3 2905 H CH3 2,6DIP H H H 2906 H CH3 2,6DIPB CD3 H H 2907 H CH3 2,6DIPB CH3 H H 2908 H CH3 2,6DIPB H CD3 H 2909 H CH3 2,6DIPB H CH3 H 2910 H CH3 2,6DIPB H H CD3 2911 H CH3 2,6DIPB H H CH3 2912 H CH3 2,6DIPB H H H 2913 H CH3 2,6DMB CD3 H H 2914 H CH3 2,6DMB CH3 H H 2915 H CH3 2,6DMB H CD3 H 2916 H CH3 2,6DMB H CH3 H 2917 H CH3 2,6DMB H H CD3 2918 H CH3 2,6DMB H H CH3 2919 H CH3 2,6DMB H H H 2920 H CH3 CD3 CD3 H H 2921 H CH3 CD3 CH3 H H 2922 H CH3 CD3 H CD3 H 2923 H CH3 CD3 H CH3 H 2924 H CH3 CD3 H H CD3 2925 H CH3 CD3 H H CH3 2926 H CH3 CD3 H H H 2927 H CH3 CH3 CD3 H H 2928 H CH3 CH3 CH3 H H 2929 H CH3 CH3 H CD3 H 2930 H CH3 CH3 H CH3 H 2931 H CH3 CH3 H H CD3 2932 H CH3 CH3 H H CH3 2933 H CH3 CH3 H H H 2934 H CH3 H 2,6DIP H H 2935 H CH3 H 2,6DMB H H 2936 H CH3 H CD3 H H 2937 H CH3 H CH3 H H 2938 H CH3 H H 2,6DIP H 2939 H CH3 H H 2,6DMB H 2940 H CH3 H H CD3 H 2941 H CH3 H H CH3 H 2942 H CH3 H H H 2,6DIP 2943 H CH3 H H H 2,6DMB 2944 H CH3 H H H CD3 2945 H CH3 H H H CH3 2946 H CH3 H H H H 2947 H CH3 H H H iPr 2948 H CH3 H H iPr H 2949 H CH3 H iPr H H 2950 H CH3 ph CD3 H H 2951 H CH3 ph CH3 H H 2952 H CH3 ph H CD3 H 2953 H CH3 ph H CH3 H 2954 H CH3 ph H H CD3 2955 H CH3 ph H H CH3 2956 H CH3 ph H H H 2957 H H 2,6DIP CD3 CD3 H 2958 H H 2,6DIP CD3 CH3 H 2959 H H 2,6DIP CD3 H CD3 2960 H H 2,6DIP CD3 H CH3 2961 H H 2,6DIP CD3 H H 2962 H H 2,6DIP CH3 CD3 H 2963 H H 2,6DIP CH3 CH3 H 2964 H H 2,6DIP CH3 H CD3 2965 H H 2,6DIP CH3 H CH3 2966 H H 2,6DIP CH3 H H 2967 H H 2,6DIP H CD3 CD3 2968 H H 2,6DIP H CD3 CH3 2969 H H 2,6DIP H CD3 H 2970 H H 2,6DIP H CH3 CD3 2971 H H 2,6DIP H CH3 CH3 2972 H H 2,6DIP H CH3 H 2973 H H 2,6DIP H H CD3 2974 H H 2,6DIP H H CH3 2975 H H 2,6DIP H H H 2976 H H 2,6DIPB CD3 CD3 H 2977 H H 2,6DIPB CD3 CH3 H 2978 H H 2,6DIPB CD3 H CD3 2979 H H 2,6DIPB CD3 H CH3 2980 H H 2,6DIPB CD3 H H 2981 H H 2,6DIPB CH3 CD3 H 2982 H H 2,6DIPB CH3 CH3 H 2983 H H 2,6DIPB CH3 H CD3 2984 H H 2,6DIPB CH3 H CH3 2985 H H 2,6DIPB CH3 H H 2986 H H 2,6DIPB H CD3 CD3 2987 H H 2,6DIPB H CD3 CH3 2988 H H 2,6DIPB H CD3 H 2989 H H 2,6DIPB H CH3 CD3 2990 H H 2,6DIPB H CH3 CH3 2991 H H 2,6DIPB H CH3 H 2992 H H 2,6DIPB H H CD3 2993 H H 2,6DIPB H H CH3 2994 H H 2,6DIPB H H H 2995 H H 2,6DMB CD3 CD3 H 2996 H H 2,6DMB CD3 CH3 H 2997 H H 2,6DMB CD3 H CD3 2998 H H 2,6DMB CD3 H CH3 2999 H H 2,6DMB CD3 H H 3000 H H 2,6DMB CH3 CD3 H 3001 H H 2,6DMB CH3 CH3 H 3002 H H 2,6DMB CH3 H CD3 3003 H H 2,6DMB CH3 H CH3 3004 H H 2,6DMB CH3 H H 3005 H H 2,6DMB H CD3 CD3 3006 H H 2,6DMB H CD3 CH3 3007 H H 2,6DMB H CD3 H 3008 H H 2,6DMB H CH3 CD3 3009 H H 2,6DMB H CH3 CH3 3010 H H 2,6DMB H CH3 H 3011 H H 2,6DMB H H CD3 3012 H H 2,6DMB H H CH3 3013 H H 2,6DMB H H H 3014 H H CD3 2,6DIP H H 3015 H H CD3 2,6DMB H H 3016 H H CD3 CD3 CD3 H 3017 H H CD3 CD3 CH3 H 3018 H H CD3 CD3 H CD3 3019 H H CD3 CD3 H CH3 3020 H H CD3 CD3 H H 3021 H H CD3 CH3 CD3 H 3022 H H CD3 CH3 CH3 H 3023 H H CD3 CH3 H CD3 3024 H H CD3 CH3 H CH3 3025 H H CD3 CH3 H H 3026 H H CD3 H 2,6DIP H 3027 H H CD3 H 2,6DMB H 3028 H H CD3 H CD3 CD3 3029 H H CD3 H CD3 CH3 3030 H H CD3 H CD3 H 3031 H H CD3 H CH3 CD3 3032 H H CD3 H CH3 CH3 3033 H H CD3 H CH3 H 3034 H H CD3 H H 2,6DIP 3035 H H CD3 H H 2,6DMB 3036 H H CD3 H H CD3 3037 H H CD3 H H CH3 3038 H H CD3 H H H 3039 H H CD3 H H iPr 3040 H H CD3 H iPr H 3041 H H CD3 iPr H H 3042 H H CH3 2,6DIP H H 3043 H H CH3 2,6DMB H H 3044 H H CH3 CD3 CD3 H 3045 H H CH3 CD3 CH3 H 3046 H H CH3 CD3 H CD3 3047 H H CH3 CD3 H CH3 3048 H H CH3 CD3 H H 3049 H H CH3 CH3 CD3 H 3050 H H CH3 CH3 CH3 H 3051 H H CH3 CH3 H CD3 3052 H H CH3 CH3 H CH3 3053 H H CH3 CH3 H H 3054 H H CH3 H 2,6DIP H 3055 H H CH3 H 2,6DMB H 3056 H H CH3 H CD3 CD3 3057 H H CH3 H CD3 CH3 3058 H H CH3 H CD3 H 3059 H H CH3 H CH3 CD3 3060 H H CH3 H CH3 CH3 3061 H H CH3 H CH3 H 3062 H H CH3 H H 2,6DIP 3063 H H CH3 H H 2,6DMB 3064 H H CH3 H H CD3 3065 H H CH3 H H CH3 3066 H H CH3 H H H 3067 H H CH3 H H iPr 3068 H H CH3 H iPr H 3069 H H CH3 iPr H H 3070 H H H 2,6DIP H CD3 3071 H H H 2,6DIP H CH3 3072 H H H 2,6DIP H H 3073 H H H 2,6DMB H CD3 3074 H H H 2,6DMB H CH3 3075 H H H 2,6DMB H H 3076 H H H CD3 CD3 H 3077 H H H CD3 CH3 H 3078 H H H CD3 H 2,6DIP 3079 H H H CD3 H 2,6DMB 3080 H H H CD3 H CD3 3081 H H H CD3 H CH3 3082 H H H CD3 H H 3083 H H H CD3 H iPr 3084 H H H CD3 iPr H 3085 H H H CH3 CD3 H 3086 H H H CH3 CH3 H 3087 H H H CH3 H 2,6DIP 3088 H H H CH3 H 2,6DMB 3089 H H H CH3 H CD3 3090 H H H CH3 H CH3 3091 H H H CH3 H H 3092 H H H CH3 H iPr 3093 H H H CH3 iPr H 3094 H H H H 2,6DIP H 3095 H H H H 2,6DMB H 3096 H H H H CD3 CD3 3097 H H H H CD3 CH3 3098 H H H H CD3 H 3099 H H H H CD3 iPr 3100 H H H H CH3 CD3 3101 H H H H CH3 CH3 3102 H H H H CH3 H 3103 H H H H CH3 iPr 3104 H H H H H 2,6DIP 3105 H H H H H 2,6DMB 3106 H H H H H CD3 3107 H H H H H CH3 3108 H H H H H H 3109 H H H H H iPr 3110 H H H H iPr CD3 3111 H H H H iPr CH3 3112 H H H H iPr H 3113 H H H iPr CD3 H 3114 H H H iPr CH3 H 3115 H H H iPr H CD3 3116 H H H iPr H CH3 3117 H H H iPr H H 3118 H H ph CD3 CD3 H 3119 H H ph CD3 CH3 H 3120 H H ph CD3 H CD3 3121 H H ph CD3 H CH3 3122 H H ph CD3 H H 3123 H H ph CH3 CD3 H 3124 H H ph CH3 CH3 H 3125 H H ph CH3 H CD3 3126 H H ph CH3 H CH3 3127 H H ph CH3 H H 3128 H H ph H CD3 CD3 3130 H H ph H CD3 H 3131 H H ph H CH3 CD3 3132 H H ph H CH3 CH3 3133 H H ph H CH3 H 3134 H H ph H H CD3 3135 H H ph H H CH3 3136 H H ph H H H 3137 H iPr CD3 H H H 3138 H iPr CH3 H H H 3139 H iPr H CD3 H H 3140 H iPr H CH3 H H 3141 H iPr H H CD3 H 3142 H iPr H H CH3 H 3143 H iPr H H H CD3 3144 H iPr H H H CH3 3145 H iPr H H H H 3146 iPr CD3 H H H H 3147 iPr CH3 H H H H 3148 iPr H CD3 H H H 3149 iPr H CH3 H H H 3150 iPr H H CD3 H H 3151 iPr H H CH3 H H 3152 iPr H H H CD3 H 3153 iPr H H H CH3 H 3154 iPr H H H H CD3 3155 iPr H H H H CH3 3156 iPr H H H H H LA3157 to LA3580 based on structure:

LA # R11 R2 R12 R31 R32 R33 3157 CD3 CD3 2,6DIP H H H 3158 CD3 CD3 2,6DMB H H H 3159 CD3 CD3 CD3 H H H 3160 CD3 CD3 CH3 H H H 3161 CD3 CD3 H H H H 3162 CD3 CD3 iPr H H H 3163 CD3 CH3 2,6DIP H H H 3164 CD3 CH3 2,6DMB H H H 3165 CD3 CH3 CD3 H H H 3166 CD3 CH3 CH3 H H H 3167 CD3 CH3 H H H H 3168 CD3 CH3 iPr H H H 3169 CD3 H 2,6DIP CD3 H H 3170 CD3 H 2,6DIP CH3 H H 3171 CD3 H 2,6DIP H CD3 H 3172 CD3 H 2,6DIP H CH3 H 3173 CD3 H 2,6DIP H H CD3 3174 CD3 H 2,6DIP H H CH3 3175 CD3 H 2,6DIP H H H 3176 CD3 H 2,6DMB CD3 H H 3177 CD3 H 2,6DMB CH3 H H 3178 CD3 H 2,6DMB H CD3 H 3179 CD3 H 2,6DMB H CH3 H 3180 CD3 H 2,6DMB H H CD3 3181 CD3 H 2,6DMB H H CH3 3182 CD3 H 2,6DMB H H H 3183 CD3 H CD3 CD3 H H 3184 CD3 H CD3 CH3 H H 3185 CD3 H CD3 H CD3 H 3186 CD3 H CD3 H CH3 H 3187 CD3 H CD3 H H CD3 3188 CD3 H CD3 H H CH3 3189 CD3 H CD3 H H H 3190 CD3 H CH3 CD3 H H 3191 CD3 H CH3 CH3 H H 3192 CD3 H CH3 H CD3 H 3193 CD3 H CH3 H CH3 H 3194 CD3 H CH3 H H CD3 3195 CD3 H CH3 H H CH3 3196 CD3 H CH3 H H H 3197 CD3 H H 2,6DIP H H 3198 CD3 H H 2,6DMB H H 3199 CD3 H H CD3 H H 3200 CD3 H H CH3 H H 3201 CD3 H H H 2,6DIP H 3202 CD3 H H H 2,6DMB H 3203 CD3 H H H CD3 H 3204 CD3 H H H CH3 H 3205 CD3 H H H H 2,6DIP 3206 CD3 H H H H 2,6DMB 3207 CD3 H H H H CD3 3208 CD3 H H H H CH3 3209 CD3 H H H H H 3210 CD3 H H H H iPr 3211 CD3 H H H iPr H 3212 CD3 H H iPr H H 3213 CD3 H iPr CD3 H H 3214 CD3 H iPr CH3 H H 3215 CD3 H iPr H CD3 H 3216 CD3 H iPr H CH3 H 3217 CD3 H iPr H H CD3 3218 CD3 H iPr H H CH3 3219 CD3 H iPr H H H 3220 CH3 CD3 2,6DIP H H H 3221 CH3 CD3 2,6DMB H H H 3222 CH3 CD3 CD3 H H H 3223 CH3 CD3 CH3 H H H 3224 CH3 CD3 H H H H 3225 CH3 CD3 iPr H H H 3226 CH3 CH3 2,6DIP H H H 3227 CH3 CH3 2,6DMB H H H 3228 CH3 CH3 CD3 H H H 3229 CH3 CH3 CH3 H H H 3230 CH3 CH3 H H H H 3231 CH3 CH3 iPr H H H 3232 CH3 H 2,6DIP CD3 H H 3233 CH3 H 2,6DIP CH3 H H 3234 CH3 H 2,6DIP H CD3 H 3235 CH3 H 2,6DIP H CH3 H 3236 CH3 H 2,6DIP H H CD3 3237 CH3 H 2,6DIP H H CH3 3238 CH3 H 2,6DIP H H H 3239 CH3 H 2,6DMB CD3 H H 3240 CH3 H 2,6DMB CH3 H H 3241 CH3 H 2,6DMB H CD3 H 3242 CH3 H 2,6DMB H CH3 H 3243 CH3 H 2,6DMB H H CD3 3244 CH3 H 2,6DMB H H CH3 3245 CH3 H 2,6DMB H H H 3246 CH3 H CD3 CD3 H H 3247 CH3 H CD3 CH3 H H 3248 CH3 H CD3 H CD3 H 3249 CH3 H CD3 H CH3 H 3250 CH3 H CD3 H H CD3 3251 CH3 H CD3 H H CH3 3252 CH3 H CD3 H H H 3253 CH3 H CH3 CD3 H H 3254 CH3 H CH3 CH3 H H 3255 CH3 H CH3 H CD3 H 3256 CH3 H CH3 H CH3 H 3257 CH3 H CH3 H H CD3 3258 CH3 H CH3 H H CH3 3259 CH3 H CH3 H H H 3260 CH3 H H 2,6DIP H H 3261 CH3 H H 2,6DMB H H 3262 CH3 H H CD3 H H 3263 CH3 H H CH3 H H 3264 CH3 H H H 2,6DIP H 3265 CH3 H H H 2,6DMB H 3266 CH3 H H H CD3 H 3267 CH3 H H H CH3 H 3268 CH3 H H H H 2,6DIP 3269 CH3 H H H H 2,6DMB 3270 CH3 H H H H CD3 3271 CH3 H H H H CH3 3272 CH3 H H H H H 3273 CH3 H H H H iPr 3274 CH3 H H H iPr H 3275 CH3 H H iPr H H 3276 CH3 H iPr CD3 H H 3277 CH3 H iPr CH3 H H 3278 CH3 H iPr H CD3 H 3279 CH3 H iPr H CH3 H 3280 CH3 H iPr H H CD3 3281 CH3 H iPr H H CH3 3282 CH3 H iPr H H H 3283 H 2,6DIP H CD3 H H 3284 H 2,6DIP H CH3 H H 3285 H 2,6DIP H H CD3 H 3286 H 2,6DIP H H CH3 H 3287 H 2,6DIP H H H CD3 3288 H 2,6DIP H H H CH3 3289 H 2,6DIP H H H H 3290 H 2,6DIPB H CD3 H H 3291 H 2,6DIPB H CH3 H H 3292 H 2,6DIPB H H CD3 H 3293 H 2,6DIPB H H CH3 H 3294 H 2,6DIPB H H H CD3 3295 H 2,6DIPB H H H CH3 3296 H 2,6DIPB H H H H 3297 H 2,6DMB H CD3 H H 3298 H 2,6DMB H CH3 H H 3299 H 2,6DMB H H CD3 H 3300 H 2,6DMB H H CH3 H 3301 H 2,6DMB H H H CD3 3302 H 2,6DMB H H H CH3 3303 H 2,6DMB H H H H 3304 H CD3 2,6DIP CD3 H H 3305 H CD3 2,6DIP CH3 H H 3306 H CD3 2,6DIP H CD3 H 3307 H CD3 2,6DIP H CH3 H 3308 H CD3 2,6DIP H H CD3 3309 H CD3 2,6DIP H H CH3 3310 H CD3 2,6DIP H H H 3311 H CD3 2,6DMB CD3 H H 3312 H CD3 2,6DMB CH3 H H 3313 H CD3 2,6DMB H CD3 H 3314 H CD3 2,6DMB H CH3 H 3315 H CD3 2,6DMB H H CD3 3316 H CD3 2,6DMB H H CH3 3317 H CD3 2,6DMB H H H 3318 H CD3 CD3 CD3 H H 3319 H CD3 CD3 CH3 H H 3320 H CD3 CD3 H CD3 H 3321 H CD3 CD3 H CH3 H 3322 H CD3 CD3 H H CD3 3323 H CD3 CD3 H H CH3 3324 H CD3 CD3 H H H 3325 H CD3 CH3 CD3 H H 3326 H CD3 CH3 CH3 H H 3327 H CD3 CH3 H CD3 H 3328 H CD3 CH3 H CH3 H 3329 H CD3 CH3 H H CD3 3330 H CD3 CH3 H H CH3 3331 H CD3 CH3 H H H 3332 H CD3 H 2,6DIP H H 3333 H CD3 H 2,6DMB H H 3334 H CD3 H CD3 H H 3335 H CD3 H CH3 H H 3336 H CD3 H H 2,6DIP H 3337 H CD3 H H 2,6DMB H 3338 H CD3 H H CD3 H 3339 H CD3 H H CH3 H 3340 H CD3 H H H 2,6DIP 3341 H CD3 H H H 2,6DMB 3342 H CD3 H H H CD3 3343 H CD3 H H H CH3 3344 H CD3 H H H H 3345 H CD3 H H H iPr 3346 H CD3 H H iPr H 3347 H CD3 H iPr H H 3348 H CD3 iPr CD3 H H 3349 H CD3 iPr CH3 H H 3350 H CD3 iPr H CD3 H 3351 H CD3 iPr H CH3 H 3352 H CD3 iPr H H CD3 3353 H CD3 iPr H H CH3 3354 H CD3 iPr H H H 3355 H CH3 2,6DIP CD3 H H 3356 H CH3 2,6DIP CH3 H H 3357 H CH3 2,6DIP H CD3 H 3358 H CH3 2,6DIP H CH3 H 3359 H CH3 2,6DIP H H CD3 3360 H CH3 2,6DIP H H CH3 3361 H CH3 2,6DIP H H H 3362 H CH3 2,6DMB CD3 H H 3363 H CH3 2,6DMB CH3 H H 3364 H CH3 2,6DMB H CD3 H 3365 H CH3 2,6DMB H CH3 H 3366 H CH3 2,6DMB H H CD3 3367 H CH3 2,6DMB H H CH3 3368 H CH3 2,6DMB H H H 3369 H CH3 CD3 CD3 H H 3370 H CH3 CD3 CH3 H H 3371 H CH3 CD3 H CD3 H 3372 H CH3 CD3 H CH3 H 3373 H CH3 CD3 H H CD3 3374 H CH3 CD3 H H CH3 3375 H CH3 CD3 H H H 3376 H CH3 CH3 CD3 H H 3377 H CH3 CH3 CH3 H H 3378 H CH3 CH3 H CD3 H 3379 H CH3 CH3 H CH3 H 3380 H CH3 CH3 H H CD3 3381 H CH3 CH3 H H CH3 3382 H CH3 CH3 H H H 3383 H CH3 H 2,6DIP H H 3384 H CH3 H 2,6DMB H H 3385 H CH3 H CD3 H H 3386 H CH3 H CH3 H H 3387 H CH3 H H 2,6DIP H 3388 H CH3 H H 2,6DMB H 3389 H CH3 H H CD3 H 3390 H CH3 H H CH3 H 3391 H CH3 H H H 2,6DIP 3392 H CH3 H H H 2,6DMB 3393 H CH3 H H H CD3 3394 H CH3 H H H CH3 3395 H CH3 H H H H 3396 H CH3 H H H iPr 3397 H CH3 H H iPr H 3398 H CH3 H iPr H H 3399 H CH3 iPr CD3 H H 3400 H CH3 iPr CH3 H H 3401 H CH3 iPr H CD3 H 3402 H CH3 iPr H CH3 H 3403 H CH3 iPr H H CD3 3404 H CH3 iPr H H CH3 3405 H CH3 iPr H H H 3406 H H 2,6DIP CD3 CD3 H 3407 H H 2,6DIP CD3 CH3 H 3408 H H 2,6DIP CD3 H CD3 3409 H H 2,6DIP CD3 H CH3 3410 H H 2,6DIP CD3 H H 3411 H H 2,6DIP CH3 CD3 H 3412 H H 2,6DIP CH3 CH3 H 3413 H H 2,6DIP CH3 H CD3 3414 H H 2,6DIP CH3 H CH3 3415 H H 2,6DIP CH3 H H 3416 H H 2,6DIP H CD3 CD3 3417 H H 2,6DIP H CD3 CH3 3418 H H 2,6DIP H CD3 H 3419 H H 2,6DIP H CH3 CD3 3420 H H 2,6DIP H CH3 CH3 3421 H H 2,6DIP H CH3 H 3422 H H 2,6DIP H H CD3 3423 H H 2,6DIP H H CH3 3424 H H 2,6DIP H H H 3425 H H 2,6DMB CD3 CD3 H 3426 H H 2,6DMB CD3 CH3 H 3427 H H 2,6DMB CD3 H CD3 3428 H H 2,6DMB CD3 H CH3 3429 H H 2,6DMB CD3 H H 3430 H H 2,6DMB CH3 CD3 H 3431 H H 2,6DMB CH3 CH3 H 3432 H H 2,6DMB CH3 H CD3 3433 H H 2,6DMB CH3 H CH3 3434 H H 2,6DMB CH3 H H 3435 H H 2,6DMB H CD3 CD3 3436 H H 2,6DMB H CD3 CH3 3437 H H 2,6DMB H CD3 H 3438 H H 2,6DMB H CH3 CD3 3439 H H 2,6DMB H CH3 CH3 3440 H H 2,6DMB H CH3 H 3441 H H 2,6DMB H H CD3 3442 H H 2,6DMB H H CH3 3443 H H 2,6DMB H H H 3444 H H CD3 CD3 CD3 H 3445 H H CD3 CD3 CH3 H 3446 H H CD3 CD3 H CD3 3447 H H CD3 CD3 H CH3 3448 H H CD3 CD3 H H 3449 H H CD3 CH3 CD3 H 3450 H H CD3 CH3 CH3 H 3451 H H CD3 CH3 H CD3 3452 H H CD3 CH3 H CH3 3453 H H CD3 CH3 H H 3454 H H CD3 H 2,6DIP H 3455 H H CD3 H 2,6DMB H 3456 H H CD3 H CD3 CD3 3457 H H CD3 H CD3 CH3 3458 H H CD3 H CD3 H 3459 H H CD3 H CH3 CD3 3460 H H CD3 H CH3 CH3 3461 H H CD3 H CH3 H 3462 H H CD3 H H 2,6DIP 3463 H H CD3 H H 2,6DMB 3464 H H CD3 H H CD3 3465 H H CD3 H H CH3 3466 H H CD3 H H H 3467 H H CD3 H H iPr 3468 H H CD3 H iPr H 3469 H H CD3 iPr H H 3470 H H CH3 CD3 CD3 H 3471 H H CH3 CD3 CH3 H 3472 H H CH3 CD3 H CD3 3473 H H CH3 CD3 H CH3 3474 H H CH3 CD3 H H 3475 H H CH3 CH3 CD3 H 3476 H H CH3 CH3 CH3 H 3477 H H CH3 CH3 H CD3 3478 H H CH3 CH3 H CH3 3479 H H CH3 CH3 H H 3480 H H CH3 H 2,6DIP H 3481 H H CH3 H 2,6DMB H 3482 H H CH3 H CD3 CD3 3483 H H CH3 H CD3 CH3 3484 H H CH3 H CD3 H 3485 H H CH3 H CH3 CD3 3486 H H CH3 H CH3 CH3 3487 H H CH3 H CH3 H 3488 H H CH3 H H 2,6DIP 3489 H H CH3 H H 2,6DMB 3490 H H CH3 H H CD3 3491 H H CH3 H H CH3 3492 H H CH3 H H H 3493 H H CH3 H H iPr 3494 H H CH3 H iPr H 3495 H H CH3 iPr H H 3496 H H H 2,6DIP H CD3 3497 H H H 2,6DIP H CH3 3498 H H H 2,6DIP H H 3499 H H H 2,6DMB H CD3 3500 H H H 2,6DMB H CH3 3501 H H H 2,6DMB H H 3502 H H H CD3 CD3 H 3503 H H H CD3 CH3 H 3504 H H H CD3 H 2,6DIP 3505 H H H CD3 H 2,6DMB 3506 H H H CD3 H CD3 3507 H H H CD3 H CH3 3508 H H H CD3 H H 3509 H H H CD3 H iPr 3510 H H H CD3 iPr H 3511 H H H CH3 CD3 H 3512 H H H CH3 CH3 H 3513 H H H CH3 H 2,6DIP 3514 H H H CH3 H 2,6DMB 3515 H H H CH3 H CD3 3516 H H H CH3 H CH3 3517 H H H CH3 H H 3518 H H H CH3 H iPr 3519 H H H CH3 iPr H 3520 H H H H 2,6DIP H 3521 H H H H 2,6DMB H 3522 H H H H CD3 CD3 3523 H H H H CD3 CH3 3524 H H H H CD3 H 3525 H H H H CD3 iPr 3526 H H H H CH3 CD3 3527 H H H H CH3 CH3 3528 H H H H CH3 H 3529 H H H H CH3 iPr 3530 H H H H H 2,6DIP 3531 H H H H H 2,6DMB 3532 H H H H H CD3 3533 H H H H H CH3 3534 H H H H H H 3535 H H H H H iPr 3536 H H H H iPr CD3 3537 H H H H iPr CH3 3538 H H H H iPr H 3539 H H H iPr CD3 H 3540 H H H iPr CH3 H 3541 H H H iPr H CD3 3542 H H H iPr H CH3 3543 H H H iPr H H 3544 H H iPr CD3 CD3 H 3545 H H iPr CD3 CH3 H 3546 H H iPr CD3 H CD3 3547 H H iPr CD3 H CH3 3548 H H iPr CD3 H H 3549 H H iPr CH3 CD3 H 3550 H H iPr CH3 CH3 H 3551 H H iPr CH3 H CD3 3552 H H iPr CH3 H CH3 3553 H H iPr CH3 H H 3554 H H iPr H CD3 CD3 3555 H H iPr H CD3 CH3 3556 H H iPr H CD3 H 3557 H H iPr H CH3 CD3 3558 H H iPr H CH3 CH3 3559 H H iPr H CH3 H 3560 H H iPr H H CD3 3561 H H iPr H H CH3 3562 H H iPr H H H 3563 H ph H CD3 H H 3564 H ph H CH3 H H 3565 H ph H H CD3 H 3566 H ph H H CH3 H 3567 H ph H H H CD3 3568 H ph H H H CH3 3569 H ph H H H H 3570 iPr CD3 H H H H 3571 iPr CH3 H H H H 3572 iPr H CD3 H H H 3573 iPr H CH3 H H H 3574 iPr H H CD3 H H 3575 iPr H H CH3 H H 3576 iPr H H H CD3 H 3577 iPr H H H CH3 H 3578 iPr H H H H CD3 3579 iPr H H H H CH3 3580 iPr H H H H H LA3851 to LA4012 based on structure:

LA # R11 R2 R12 R31 R32 R34 3581 CD3 CD3 2,6DIP H H H 3582 CD3 CD3 2,6DMB H H H 3583 CD3 CD3 CD3 H H H 3584 CD3 CD3 CH3 H H H 3585 CD3 CD3 H H H H 3586 CD3 CD3 iPr H H H 3587 CD3 CH3 2,6DIP H H H 3588 CD3 CH3 2,6DMB H H H 3589 CD3 CH3 CD3 H H H 3590 CD3 CH3 CH3 H H H 3591 CD3 CH3 H H H H 3592 CD3 CH3 iPr H H H 3593 CD3 H 2,6DIP CD3 H H 3594 CD3 H 2,6DIP CH3 H H 3595 CD3 H 2,6DIP H CD3 H 3596 CD3 H 2,6DIP H CH3 H 3597 CD3 H 2,6DIP H H CD3 3598 CD3 H 2,6DIP H H CH3 3599 CD3 H 2,6DIP H H H 3600 CD3 H 2,6DMB CD3 H H 3601 CD3 H 2,6DMB CH3 H H 3602 CD3 H 2,6DMB H CD3 H 3603 CD3 H 2,6DMB H CH3 H 3604 CD3 H 2,6DMB H H CD3 3605 CD3 H 2,6DMB H H CH3 3606 CD3 H 2,6DMB H H H 3607 CD3 H CD3 CD3 H H 3608 CD3 H CD3 CH3 H H 3609 CD3 H CD3 H CD3 H 3610 CD3 H CD3 H CH3 H 3611 CD3 H CD3 H H CD3 3612 CD3 H CD3 H H CH3 3613 CD3 H CD3 H H H 3614 CD3 H CH3 CD3 H H 3615 CD3 H CH3 CH3 H H 3616 CD3 H CH3 H CD3 H 3617 CD3 H CH3 H CH3 H 3618 CD3 H CH3 H H CD3 3619 CD3 H CH3 H H CH3 3620 CD3 H CH3 H H H 3621 CD3 H H 2,6DIP H H 3622 CD3 H H 2,6DMB H H 3623 CD3 H H CD3 H H 3624 CD3 H H CH3 H H 3625 CD3 H H H 2,6DIP H 3626 CD3 H H H 2,6DMB H 3627 CD3 H H H CD3 H 3628 CD3 H H H CH3 H 3629 CD3 H H H H 2,6DIP 3630 CD3 H H H H 2,6DMB 3631 CD3 H H H H CD3 3632 CD3 H H H H CH3 3633 CD3 H H H H H 3634 CD3 H H H H iPr 3635 CD3 H H H iPr H 3636 CD3 H H iPr H H 3637 CD3 H iPr CD3 H H 3638 CD3 H iPr CH3 H H 3639 CD3 H iPr H CD3 H 3640 CD3 H iPr H CH3 H 3641 CD3 H iPr H H CD3 3642 CD3 H iPr H H CH3 3643 CD3 H iPr H H H 3644 CH3 CD3 2,6DIP H H H 3645 CH3 CD3 2,6DMB H H H 3646 CH3 CD3 CD3 H H H 3647 CH3 CD3 CH3 H H H 3648 CH3 CD3 H H H H 3649 CH3 CD3 iPr H H H 3650 CH3 CH3 2,6DIP H H H 3651 CH3 CH3 2,6DMB H H H 3652 CH3 CH3 CD3 H H H 3653 CH3 CH3 CH3 H H H 3654 CH3 CH3 H H H H 3655 CH3 CH3 iPr H H H 3656 CH3 H 2,6DIP CD3 H H 3657 CH3 H 2,6DIP CH3 H H 3658 CH3 H 2,6DIP H CD3 H 3659 CH3 H 2,6DIP H CH3 H 3660 CH3 H 2,6DIP H H CD3 3661 CH3 H 2,6DIP H H CH3 3662 CH3 H 2,6DIP H H H 3663 CH3 H 2,6DMB CD3 H H 3664 CH3 H 2,6DMB CH3 H H 3665 CH3 H 2,6DMB H CD3 H 3666 CH3 H 2,6DMB H CH3 H 3667 CH3 H 2,6DMB H H CD3 3668 CH3 H 2,6DMB H H CH3 3669 CH3 H 2,6DMB H H H 3670 CH3 H CD3 CD3 H H 3671 CH3 H CD3 CH3 H H 3672 CH3 H CD3 H CD3 H 3673 CH3 H CD3 H CH3 H 3674 CH3 H CD3 H H CD3 3675 CH3 H CD3 H H CH3 3676 CH3 H CD3 H H H 3677 CH3 H CH3 CD3 H H 3678 CH3 H CH3 CH3 H H 3679 CH3 H CH3 H CD3 H 3680 CH3 H CH3 H CH3 H 3681 CH3 H CH3 H H CD3 3682 CH3 H CH3 H H CH3 3683 CH3 H CH3 H H H 3684 CH3 H H 2,6DIP H H 3685 CH3 H H 2,6DMB H H 3686 CH3 H H CD3 H H 3687 CH3 H H CH3 H H 3688 CH3 H H H 2,6DIP H 3689 CH3 H H H 2,6DMB H 3690 CH3 H H H CD3 H 3691 CH3 H H H CH3 H 3692 CH3 H H H H 2,6DIP 3693 CH3 H H H H 2,6DMB 3694 CH3 H H H H CD3 3695 CH3 H H H H CH3 3696 CH3 H H H H H 3697 CH3 H H H H iPr 3698 CH3 H H H iPr H 3699 CH3 H H iPr H H 3700 CH3 H iPr CD3 H H 3701 CH3 H iPr CH3 H H 3702 CH3 H iPr H CD3 H 3703 CH3 H iPr H CH3 H 3704 CH3 H iPr H H CD3 3705 CH3 H iPr H H CH3 3706 CH3 H iPr H H H 3707 H 2,6DIP H CD3 H H 3708 H 2,6DIP H CH3 H H 3709 H 2,6DIP H H CD3 H 3710 H 2,6DIP H H CH3 H 3711 H 2,6DIP H H H CD3 3712 H 2,6DIP H H H CH3 3713 H 2,6DIP H H H H 3714 H 2,6DIPB H CD3 H H 3715 H 2,6DIPB H CH3 H H 3716 H 2,6DIPB H H CD3 H 3717 H 2,6DIPB H H CH3 H 3718 H 2,6DIPB H H H CD3 3719 H 2,6DIPB H H H CH3 3720 H 2,6DIPB H H H H 3721 H 2,6DMB H CD3 H H 3722 H 2,6DMB H CH3 H H 3723 H 2,6DMB H H CD3 H 3724 H 2,6DMB H H CH3 H 3725 H 2,6DMB H H H CD3 3726 H 2,6DMB H H H CH3 3727 H 2,6DMB H H H H 3728 H CD3 2,6DIP CD3 H H 3729 H CD3 2,6DIP CH3 H H 3730 H CD3 2,6DIP H CD3 H 3731 H CD3 2,6DIP H CH3 H 3732 H CD3 2,6DIP H H CD3 3733 H CD3 2,6DIP H H CH3 3734 H CD3 2,6DIP H H H 3735 H CD3 2,6DMB CD3 H H 3736 H CD3 2,6DMB CH3 H H 3737 H CD3 2,6DMB H CD3 H 3738 H CD3 2,6DMB H CH3 H 3739 H CD3 2,6DMB H H CD3 3740 H CD3 2,6DMB H H CH3 3741 H CD3 2,6DMB H H H 3742 H CD3 CD3 CD3 H H 3743 H CD3 CD3 CH3 H H 3744 H CD3 CD3 H CD3 H 3745 H CD3 CD3 H CH3 H 3746 H CD3 CD3 H H CD3 3747 H CD3 CD3 H H CH3 3748 H CD3 CD3 H H H 3749 H CD3 CH3 CD3 H H 3750 H CD3 CH3 CH3 H H 3751 H CD3 CH3 H CD3 H 3752 H CD3 CH3 H CH3 H 3753 H CD3 CH3 H H CD3 3754 H CD3 CH3 H H CH3 3755 H CD3 CH3 H H H 3756 H CD3 H 2,6DIP H H 3757 H CD3 H 2,6DMB H H 3758 H CD3 H CD3 H H 3759 H CD3 H CH3 H H 3760 H CD3 H H 2,6DIP H 3761 H CD3 H H 2,6DMB H 3762 H CD3 H H CD3 H 3763 H CD3 H H CH3 H 3764 H CD3 H H H 2,6DIP 3765 H CD3 H H H 2,6DMB 3766 H CD3 H H H CD3 3767 H CD3 H H H CH3 3768 H CD3 H H H H 3769 H CD3 H H H iPr 3770 H CD3 H H iPr H 3771 H CD3 H iPr H H 3772 H CD3 iPr CD3 H H 3773 H CD3 iPr CH3 H H 3774 H CD3 iPr H CD3 H 3775 H CD3 iPr H CH3 H 3776 H CD3 iPr H H CD3 3777 H CD3 iPr H H CH3 3778 H CD3 iPr H H H 3779 H CH3 2,6DIP CD3 H H 3780 H CH3 2,6DIP CH3 H H 3781 H CH3 2,6DIP H CD3 H 3782 H CH3 2,6DIP H CH3 H 3783 H CH3 2,6DIP H H CD3 3784 H CH3 2,6DIP H H CH3 3785 H CH3 2,6DIP H H H 3786 H CH3 2,6DMB CD3 H H 3787 H CH3 2,6DMB CH3 H H 3788 H CH3 2,6DMB H CD3 H 3789 H CH3 2,6DMB H CH3 H 3790 H CH3 2,6DMB H H CD3 3791 H CH3 2,6DMB H H CH3 3792 H CH3 2,6DMB H H H 3793 H CH3 CD3 CD3 H H 3794 H CH3 CD3 CH3 H H 3795 H CH3 CD3 H CD3 H 3796 H CH3 CD3 H CH3 H 3797 H CH3 CD3 H H CD3 3798 H CH3 CD3 H H CH3 3799 H CH3 CD3 H H H 3800 H CH3 CH3 CD3 H H 3801 H CH3 CH3 CH3 H H 3802 H CH3 CH3 H CD3 H 3803 H CH3 CH3 H CH3 H 3804 H CH3 CH3 H H CD3 3805 H CH3 CH3 H H CH3 3806 H CH3 CH3 H H H 3807 H CH3 H 2,6DIP H H 3808 H CH3 H 2,6DMB H H 3809 H CH3 H CD3 H H 3810 H CH3 H CH3 H H 3811 H CH3 H H 2,6DIP H 3812 H CH3 H H 2,6DMB H 3813 H CH3 H H CD3 H 3814 H CH3 H H CH3 H 3815 H CH3 H H H 2,6DIP 3816 H CH3 H H H 2,6DMB 3817 H CH3 H H H CD3 3818 H CH3 H H H CH3 3819 H CH3 H H H H 3820 H CH3 H H H iPr 3821 H CH3 H H iPr H 3822 H CH3 H iPr H H 3823 H CH3 iPr CD3 H H 3824 H CH3 iPr CH3 H H 3825 H CH3 iPr H CD3 H 3826 H CH3 iPr H CH3 H 3827 H CH3 iPr H H CD3 3828 H CH3 iPr H H CH3 3829 H CH3 iPr H H H 3830 H H 2,6DIP CD3 CD3 H 3831 H H 2,6DIP CD3 CH3 H 3832 H H 2,6DIP CD3 H CD3 3833 H H 2,6DIP CD3 H CH3 3834 H H 2,6DIP CD3 H H 3835 H H 2,6DIP CH3 CD3 H 3836 H H 2,6DIP CH3 CH3 H 3837 H H 2,6DIP CH3 H CD3 3838 H H 2,6DIP CH3 H CH3 3839 H H 2,6DIP CH3 H H 3840 H H 2,6DIP H CD3 CD3 3841 H H 2,6DIP H CD3 CH3 3842 H H 2,6DIP H CD3 H 3843 H H 2,6DIP H CH3 CD3 3844 H H 2,6DIP H CH3 CH3 3845 H H 2,6DIP H CH3 H 3846 H H 2,6DIP H H CD3 3847 H H 2,6DIP H H CH3 3848 H H 2,6DIP H H H 3849 H H 2,6DMB CD3 CD3 H 3850 H H 2,6DMB CD3 CH3 H 3851 H H 2,6DMB CD3 H CD3 3852 H H 2,6DMB CD3 H CH3 3853 H H 2,6DMB CD3 H H 3854 H H 2,6DMB CH3 CD3 H 3855 H H 2,6DMB CH3 CH3 H 3856 H H 2,6DMB CH3 H CD3 3857 H H 2,6DMB CH3 H CH3 3858 H H 2,6DMB CH3 H H 3859 H H 2,6DMB H CD3 CD3 3860 H H 2,6DMB H CD3 CH3 3861 H H 2,6DMB H CD3 H 3862 H H 2,6DMB H CH3 CD3 3863 H H 2,6DMB H CH3 CH3 3864 H H 2,6DMB H CH3 H 3865 H H 2,6DMB H H CD3 3866 H H 2,6DMB H H CH3 3867 H H 2,6DMB H H H 3868 H H CD3 CD3 CD3 H 3869 H H CD3 CD3 CH3 H 3870 H H CD3 CD3 H CD3 3871 H H CD3 CD3 H CH3 3872 H H CD3 CD3 H H 3873 H H CD3 CH3 CD3 H 3874 H H CD3 CH3 CH3 H 3875 H H CD3 CH3 H CD3 3876 H H CD3 CH3 H CH3 3877 H H CD3 CH3 H H 3878 H H CD3 H 2,6DIP H 3879 H H CD3 H 2,6DMB H 3880 H H CD3 H CD3 CD3 3881 H H CD3 H CD3 CH3 3882 H H CD3 H CD3 H 3883 H H CD3 H CH3 CD3 3884 H H CD3 H CH3 CH3 3885 H H CD3 H CH3 H 3886 H H CD3 H H 2,6DIP 3887 H H CD3 H H 2,6DMB 3888 H H CD3 H H CD3 3889 H H CD3 H H CH3 3890 H H CD3 H H H 3891 H H CD3 H H iPr 3892 H H CD3 H iPr H 3893 H H CD3 iPr H H 3894 H H CH3 CD3 CD3 H 3895 H H CH3 CD3 CH3 H 3896 H H CH3 CD3 H CD3 3897 H H CH3 CD3 H CH3 3898 H H CH3 CD3 H H 3899 H H CH3 CH3 CD3 H 3900 H H CH3 CH3 CH3 H 3901 H H CH3 CH3 H CD3 3902 H H CH3 CH3 H CH3 3903 H H CH3 CH3 H H 3904 H H CH3 H 2,6DIP H 3905 H H CH3 H 2,6DMB H 3906 H H CH3 H CD3 CD3 3907 H H CH3 H CD3 CH3 3908 H H CH3 H CD3 H 3909 H H CH3 H CH3 CD3 3910 H H CH3 H CH3 CH3 3911 H H CH3 H CH3 H 3912 H H CH3 H H 2,6DIP 3913 H H CH3 H H 2,6DMB 3914 H H CH3 H H CD3 3915 H H CH3 H H CH3 3916 H H CH3 H H H 3917 H H CH3 H H iPr 3918 H H CH3 H iPr H 3919 H H CH3 iPr H H 3920 H H H 2,6DIP H CD3 3921 H H H 2,6DIP H CH3 3922 H H H 2,6DIP H H 3923 H H H 2,6DMB H CD3 3924 H H H 2,6DMB H CH3 3925 H H H 2,6DMB H H 3926 H H H CD3 CD3 H 3927 H H H CD3 CH3 H 3928 H H H CD3 H 2,6DIP 3929 H H H CD3 H 2,6DMB 3930 H H H CD3 H CD3 3931 H H H CD3 H CH3 3932 H H H CD3 H H 3933 H H H CD3 H iPr 3934 H H H CD3 iPr H 3935 H H H CH3 CD3 H 3936 H H H CH3 CH3 H 3937 H H H CH3 H 2,6DIP 3938 H H H CH3 H 2,6DMB 3939 H H H CH3 H CD3 3940 H H H CH3 H CH3 3941 H H H CH3 H H 3942 H H H CH3 H iPr 3943 H H H CH3 iPr H 3944 H H H H 2,6DIP CD3 3945 H H H H 2,6DIP CH3 3946 H H H H 2,6DIP H 3947 H H H H 2,6DMB CD3 3948 H H H H 2,6DMB CH3 3949 H H H H 2,6DMB H 3950 H H H H CD3 2,6DIP 3951 H H H H CD3 2,6DMB 3952 H H H H CD3 CD3 3953 H H H H CD3 CH3 3954 H H H H CD3 H 3955 H H H H CD3 iPr 3956 H H H H CH3 2,6DIP 3957 H H H H CH3 2,6DMB 3958 H H H H CH3 CD3 3959 H H H H CH3 CH3 3960 H H H H CH3 H 3961 H H H H CH3 iPr 3962 H H H H H 2,6DIP 3963 H H H H H 2,6DMB 3964 H H H H H CD3 3965 H H H H H CH3 3966 H H H H H H 3967 H H H H H iPr 3968 H H H H iPr CD3 3969 H H H H iPr CH3 3970 H H H H iPr H 3971 H H H iPr CD3 H 3972 H H H iPr CH3 H 3973 H H H iPr H CD3 3974 H H H iPr H CH3 3975 H H H iPr H H 3976 H H iPr CD3 CD3 H 3977 H H iPr CD3 CH3 H 3978 H H iPr CD3 H CD3 3979 H H iPr CD3 H CH3 3980 H H iPr CD3 H H 3981 H H iPr CH3 CD3 H 3982 H H iPr CH3 CH3 H 3983 H H iPr CH3 H CD3 3984 H H iPr CH3 H CH3 3985 H H iPr CH3 H H 3986 H H iPr H CD3 CD3 3987 H H iPr H CD3 CH3 3988 H H iPr H CD3 H 3989 H H iPr H CH3 CD3 3990 H H iPr H CH3 CH3 3991 H H iPr H CH3 H 3992 H H iPr H H CD3 3993 H H iPr H H CH3 3994 H H iPr H H H 3995 H ph H CD3 H H 3996 H ph H CH3 H H 3997 H ph H H CD3 H 3998 H ph H H CH3 H 3999 H ph H H H CD3 4000 H ph H H H CH3 4001 H ph H H H H 4002 iPr CD3 H H H H 4003 iPr CH3 H H H H 4004 iPr H CD3 H H H 4005 iPr H CH3 H H H 4006 iPr H H CD3 H H 4007 iPr H H CH3 H H 4008 iPr H H H CD3 H 4009 iPr H H H CH3 H 4010 iPr H H H H CD3 4011 iPr H H H H CH3 4012 iPr H H H H H LA4013 to LA4444 based on structure:

LA # R11 R2 R12 R31 R33 R34 4013 CD3 CD3 2,6DIP H H H 4014 CD3 CD3 2,6DMB H H H 4015 CD3 CD3 CD3 H H H 4016 CD3 CD3 CH3 H H H 4017 CD3 CD3 H H H H 4018 CD3 CD3 iPr H H H 4019 CD3 CH3 2,6DIP H H H 4020 CD3 CH3 2,6DMB H H H 4021 CD3 CH3 CD3 H H H 4022 CD3 CH3 CH3 H H H 4023 CD3 CH3 H H H H 4024 CD3 CH3 iPr H H H 4025 CD3 H 2,6DIP CD3 H H 4026 CD3 H 2,6DIP CH3 H H 4027 CD3 H 2,6DIP H CD3 H 4028 CD3 H 2,6DIP H CH3 H 4029 CD3 H 2,6DIP H H CD3 4030 CD3 H 2,6DIP H H CH3 4031 CD3 H 2,6DIP H H H 4032 CD3 H 2,6DMB CD3 H H 4033 CD3 H 2,6DMB CH3 H H 4034 CD3 H 2,6DMB H CD3 H 4035 CD3 H 2,6DMB H CH3 H 4036 CD3 H 2,6DMB H H CD3 4037 CD3 H 2,6DMB H H CH3 4038 CD3 H 2,6DMB H H H 4039 CD3 H CD3 CD3 H H 4040 CD3 H CD3 CH3 H H 4041 CD3 H CD3 H CD3 H 4042 CD3 H CD3 H CH3 H 4043 CD3 H CD3 H H CD3 4044 CD3 H CD3 H H CH3 4045 CD3 H CD3 H H H 4046 CD3 H CH3 CD3 H H 4047 CD3 H CH3 CH3 H H 4048 CD3 H CH3 H CD3 H 4049 CD3 H CH3 H CH3 H 4050 CD3 H CH3 H H CD3 4051 CD3 H CH3 H H CH3 4052 CD3 H CH3 H H H 4053 CD3 H H 2,6DIP H H 4054 CD3 H H 2,6DMB H H 4055 CD3 H H CD3 H H 4056 CD3 H H CH3 H H 4057 CD3 H H H 2,6DIP H 4058 CD3 H H H 2,6DMB H 4059 CD3 H H H CD3 H 4060 CD3 H H H CH3 H 4061 CD3 H H H H 2,6DIP 4062 CD3 H H H H 2,6DMB 4063 CD3 H H H H CD3 4064 CD3 H H H H CH3 4065 CD3 H H H H H 4066 CD3 H H H H iPr 4067 CD3 H H H iPr H 4068 CD3 H H iPr H H 4069 CD3 H iPr CD3 H H 4070 CD3 H iPr CH3 H H 4071 CD3 H iPr H CD3 H 4072 CD3 H iPr H CH3 H 4073 CD3 H iPr H H CD3 4074 CD3 H iPr H H CH3 4075 CD3 H iPr H H H 4076 CH3 CD3 2,6DIP H H H 4077 CH3 CD3 2,6DMB H H H 4078 CH3 CD3 CD3 H H H 4079 CH3 CD3 CH3 H H H 4080 CH3 CD3 H H H H 4081 CH3 CD3 iPr H H H 4082 CH3 CH3 2,6DIP H H H 4083 CH3 CH3 2,6DMB H H H 4084 CH3 CH3 CD3 H H H 4085 CH3 CH3 CH3 H H H 4086 CH3 CH3 H H H H 4087 CH3 CH3 iPr H H H 4088 CH3 H 2,6DIP CD3 H H 4089 CH3 H 2,6DIP CH3 H H 4090 CH3 H 2,6DIP H CD3 H 4091 CH3 H 2,6DIP H CH3 H 4092 CH3 H 2,6DIP H H CD3 4093 CH3 H 2,6DIP H H CH3 4094 CH3 H 2,6DIP H H H 4095 CH3 H 2,6DMB CD3 H H 4096 CH3 H 2,6DMB CH3 H H 4097 CH3 H 2,6DMB H CD3 H 4098 CH3 H 2,6DMB H CH3 H 4099 CH3 H 2,6DMB H H CD3 4100 CH3 H 2,6DMB H H CH3 4101 CH3 H 2,6DMB H H H 4102 CH3 H CD3 CD3 H H 4103 CH3 H CD3 CH3 H H 4104 CH3 H CD3 H CD3 H 4105 CH3 H CD3 H CH3 H 4106 CH3 H CD3 H H CD3 4107 CH3 H CD3 H H CH3 4108 CH3 H CD3 H H H 4109 CH3 H CH3 CD3 H H 4110 CH3 H CH3 CH3 H H 4111 CH3 H CH3 H CD3 H 4112 CH3 H CH3 H CH3 H 4113 CH3 H CH3 H H CD3 4114 CH3 H CH3 H H CH3 4115 CH3 H CH3 H H H 4116 CH3 H H 2,6DIP H H 4117 CH3 H H 2,6DMB H H 4118 CH3 H H CD3 H H 4119 CH3 H H CH3 H H 4120 CH3 H H H 2,6DIP H 4121 CH3 H H H 2,6DMB H 4122 CH3 H H H CD3 H 4123 CH3 H H H CH3 H 4124 CH3 H H H H 2,6DIP 4125 CH3 H H H H 2,6DMB 4126 CH3 H H H H CD3 4127 CH3 H H H H CH3 4128 CH3 H H H H H 4129 CH3 H H H H iPr 4130 CH3 H H H iPr H 4131 CH3 H H iPr H H 4132 CH3 H iPr CD3 H H 4133 CH3 H iPr CH3 H H 4134 CH3 H iPr H CD3 H 4135 CH3 H iPr H CH3 H 4136 CH3 H iPr H H CD3 4137 CH3 H iPr H H CH3 4138 CH3 H iPr H H H 4139 H 2,6DIP H CD3 H H 4140 H 2,6DIP H CH3 H H 4141 H 2,6DIP H H CD3 H 4142 H 2,6DIP H H CH3 H 4143 H 2,6DIP H H H CD3 4144 H 2,6DIP H H H CH3 4145 H 2,6DIP H H H H 4146 H 2,6DIPB H CD3 H H 4147 H 2,6DIPB H CH3 H H 4148 H 2,6DIPB H H CD3 H 4149 H 2,6DIPB H H CH3 H 4150 H 2,6DIPB H H H CD3 4151 H 2,6DIPB H H H CH3 4152 H 2,6DIPB H H H H 4153 H 2,6DMB H CD3 H H 4154 H 2,6DMB H CH3 H H 4155 H 2,6DMB H H CD3 H 4156 H 2,6DMB H H CH3 H 4157 H 2,6DMB H H H CD3 4158 H 2,6DMB H H H CH3 4159 H 2,6DMB H H H H 4160 H CD3 2,6DIP CD3 H H 4161 H CD3 2,6DIP CH3 H H 4162 H CD3 2,6DIP H CD3 H 4163 H CD3 2,6DIP H CH3 H 4164 H CD3 2,6DIP H H CD3 4165 H CD3 2,6DIP H H CH3 4166 H CD3 2,6DIP H H H 4167 H CD3 2,6DMB CD3 H H 4168 H CD3 2,6DMB CH3 H H 4169 H CD3 2,6DMB H CD3 H 4170 H CD3 2,6DMB H CH3 H 4171 H CD3 2,6DMB H H CD3 4172 H CD3 2,6DMB H H CH3 4173 H CD3 2,6DMB H H H 4174 H CD3 CD3 CD3 H H 4175 H CD3 CD3 CH3 H H 4176 H CD3 CD3 H CD3 H 4177 H CD3 CD3 H CH3 H 4178 H CD3 CD3 H H CD3 4179 H CD3 CD3 H H CH3 4180 H CD3 CD3 H H H 4181 H CD3 CH3 CD3 H H 4182 H CD3 CH3 CH3 H H 4183 H CD3 CH3 H CD3 H 4184 H CD3 CH3 H CH3 H 4185 H CD3 CH3 H H CD3 4186 H CD3 CH3 H H CH3 4187 H CD3 CH3 H H H 4188 H CD3 H 2,6DIP H H 4189 H CD3 H 2,6DMB H H 4190 H CD3 H CD3 H H 4191 H CD3 H CH3 H H 4192 H CD3 H H 2,6DIP H 4193 H CD3 H H 2,6DMB H 4194 H CD3 H H CD3 H 4195 H CD3 H H CH3 H 4196 H CD3 H H H 2,6DIP 4197 H CD3 H H H 2,6DMB 4198 H CD3 H H H CD3 4199 H CD3 H H H CH3 4200 H CD3 H H H H 4201 H CD3 H H H iPr 4202 H CD3 H H iPr H 4203 H CD3 H iPr H H 4204 H CD3 iPr CD3 H H 4205 H CD3 iPr CH3 H H 4206 H CD3 iPr H CD3 H 4207 H CD3 iPr H CH3 H 4208 H CD3 iPr H H CD3 4209 H CD3 iPr H H CH3 4210 H CD3 iPr H H H 4211 H CH3 2,6DIP CD3 H H 4212 H CH3 2,6DIP CH3 H H 4213 H CH3 2,6DIP H CD3 H 4214 H CH3 2,6DIP H CH3 H 4215 H CH3 2,6DIP H H CD3 4216 H CH3 2,6DIP H H CH3 4217 H CH3 2,6DIP H H H 4218 H CH3 2,6DMB CD3 H H 4219 H CH3 2,6DMB CH3 H H 4220 H CH3 2,6DMB H CD3 H 4221 H CH3 2,6DMB H CH3 H 4222 H CH3 2,6DMB H H CD3 4223 H CH3 2,6DMB H H CH3 4224 H CH3 2,6DMB H H H 4225 H CH3 CD3 CD3 H H 4226 H CH3 CD3 CH3 H H 4227 H CH3 CD3 H CD3 H 4228 H CH3 CD3 H CH3 H 4229 H CH3 CD3 H H CD3 4230 H CH3 CD3 H H CH3 4231 H CH3 CD3 H H H 4232 H CH3 CH3 CD3 H H 4233 H CH3 CH3 CH3 H H 4234 H CH3 CH3 H CD3 H 4235 H CH3 CH3 H CH3 H 4236 H CH3 CH3 H H CD3 4237 H CH3 CH3 H H CH3 4238 H CH3 CH3 H H H 4239 H CH3 H 2,6DIP H H 4240 H CH3 H 2,6DMB H H 4241 H CH3 H CD3 H H 4242 H CH3 H CH3 H H 4243 H CH3 H H 2,6DIP H 4244 H CH3 H H 2,6DMB H 4245 H CH3 H H CD3 H 4246 H CH3 H H CH3 H 4247 H CH3 H H H 2,6DIP 4248 H CH3 H H H 2,6DMB 4249 H CH3 H H H CD3 4250 H CH3 H H H CH3 4251 H CH3 H H H H 4252 H CH3 H H H iPr 4253 H CH3 H H iPr H 4254 H CH3 H iPr H H 4255 H CH3 iPr CD3 H H 4256 H CH3 iPr CH3 H H 4257 H CH3 iPr H CD3 H 4258 H CH3 iPr H CH3 H 4259 H CH3 iPr H H CD3 4260 H CH3 iPr H H CH3 4261 H CH3 iPr H H H 4262 H H 2,6DIP CD3 CD3 H 4263 H H 2,6DIP CD3 CH3 H 4264 H H 2,6DIP CD3 H CD3 4265 H H 2,6DIP CD3 H CH3 4266 H H 2,6DIP CD3 H H 4267 H H 2,6DIP CH3 CD3 H 4268 H H 2,6DIP CH3 CH3 H 4269 H H 2,6DIP CH3 H CD3 4270 H H 2,6DIP CH3 H CH3 4271 H H 2,6DIP CH3 H H 4272 H H 2,6DIP H CD3 CD3 4273 H H 2,6DIP H CD3 CH3 4274 H H 2,6DIP H CD3 H 4275 H H 2,6DIP H CH3 CD3 4276 H H 2,6DIP H CH3 CH3 4277 H H 2,6DIP H CH3 H 4278 H H 2,6DIP H H CD3 4279 H H 2,6DIP H H CH3 4280 H H 2,6DIP H H H 4281 H H 2,6DMB CD3 CD3 H 4282 H H 2,6DMB CD3 CH3 H 4283 H H 2,6DMB CD3 H CD3 4284 H H 2,6DMB CD3 H CH3 4285 H H 2,6DMB CD3 H H 4286 H H 2,6DMB CH3 CD3 H 4287 H H 2,6DMB CH3 CH3 H 4288 H H 2,6DMB CH3 H CD3 4289 H H 2,6DMB CH3 H CH3 4290 H H 2,6DMB CH3 H H 4291 H H 2,6DMB H CD3 CD3 4292 H H 2,6DMB H CD3 CH3 4293 H H 2,6DMB H CD3 H 4294 H H 2,6DMB H CH3 CD3 4295 H H 2,6DMB H CH3 CH3 4296 H H 2,6DMB H CH3 H 4297 H H 2,6DMB H H CD3 4298 H H 2,6DMB H H CH3 4299 H H 2,6DMB H H H 4300 H H CD3 CD3 CD3 H 4301 H H CD3 CD3 CH3 H 4302 H H CD3 CD3 H CD3 4303 H H CD3 CD3 H CH3 4304 H H CD3 CD3 H H 4305 H H CD3 CH3 CD3 H 4306 H H CD3 CH3 CH3 H 4307 H H CD3 CH3 H CD3 4308 H H CD3 CH3 H CH3 4309 H H CD3 CH3 H H 4310 H H CD3 H 2,6DIP H 4311 H H CD3 H 2,6DMB H 4312 H H CD3 H CD3 CD3 4313 H H CD3 H CD3 CH3 4314 H H CD3 H CD3 H 4315 H H CD3 H CH3 CD3 4316 H H CD3 H CH3 CH3 4317 H H CD3 H CH3 H 4318 H H CD3 H H 2,6DIP 4319 H H CD3 H H 2,6DMB 4320 H H CD3 H H CD3 4321 H H CD3 H H CH3 4322 H H CD3 H H H 4323 H H CD3 H H iPr 4324 H H CD3 H iPr H 4325 H H CD3 iPr H H 4326 H H CH3 CD3 CD3 H 4327 H H CH3 CD3 CH3 H 4328 H H CH3 CD3 H CD3 4329 H H CH3 CD3 H CH3 4330 H H CH3 CD3 H H 4331 H H CH3 CH3 CD3 H 4332 H H CH3 CH3 CH3 H 4333 H H CH3 CH3 H CD3 4334 H H CH3 CH3 H CH3 4335 H H CH3 CH3 H H 4336 H H CH3 H 2,6DIP H 4337 H H CH3 H 2,6DMB H 4338 H H CH3 H CD3 CD3 4339 H H CH3 H CD3 CH3 4340 H H CH3 H CD3 H 4341 H H CH3 H CH3 CD3 4342 H H CH3 H CH3 CH3 4343 H H CH3 H CH3 H 4344 H H CH3 H H 2,6DIP 4345 H H CH3 H H 2,6DMB 4346 H H CH3 H H CD3 4347 H H CH3 H H CH3 4348 H H CH3 H H H 4349 H H CH3 H H iPr 4350 H H CH3 H iPr H 4351 H H CH3 iPr H H 4352 H H H 2,6DIP CD3 H 4353 H H H 2,6DIP CH3 H 4354 H H H 2,6DIP H CD3 4355 H H H 2,6DIP H CH3 4356 H H H 2,6DIP H H 4357 H H H 2,6DMB CD3 H 4358 H H H 2,6DMB CH3 H 4359 H H H 2,6DMB H CD3 4360 H H H 2,6DMB H CH3 4361 H H H 2,6DMB H H 4362 H H H CD3 2,6DIP H 4363 H H H CD3 2,6DMB H 4364 H H H CD3 CD3 H 4365 H H H CD3 CH3 H 4366 H H H CD3 H 2,6DIP 4367 H H H CD3 H 2,6DMB 4368 H H H CD3 H CD3 4369 H H H CD3 H CH3 4370 H H H CD3 H H 4371 H H H CD3 H iPr 4372 H H H CD3 iPr H 4373 H H H CH3 2,6DIP H 4374 H H H CH3 2,6DMB H 4375 H H H CH3 CD3 H 4376 H H H CH3 CH3 H 4377 H H H CH3 H 2,6DIP 4378 H H H CH3 H 2,6DMB 4379 H H H CH3 H CD3 4380 H H H CH3 H CH3 4381 H H H CH3 H H 4382 H H H CH3 H iPr 4383 H H H CH3 iPr H 4384 H H H H 2,6DIP H 4385 H H H H 2,6DMB H 4386 H H H H CD3 CD3 4387 H H H H CD3 CH3 4388 H H H H CD3 H 4389 H H H H CD3 iPr 4390 H H H H CH3 CD3 4391 H H H H CH3 CH3 4392 H H H H CH3 H 4393 H H H H CH3 iPr 4394 H H H H H 2,6DIP 4395 H H H H H 2,6DMB 4396 H H H H H CD3 4397 H H H H H CH3 4398 H H H H H H 4399 H H H H H iPr 4400 H H H H iPr CD3 4401 H H H H iPr CH3 4402 H H H H iPr H 4403 H H H iPr CD3 H 4404 H H H iPr CH3 H 4405 H H H iPr H CD3 4406 H H H iPr H CH3 4407 H H H iPr H H 4408 H H iPr CD3 CD3 H 4409 H H iPr CD3 CH3 H 4410 H H iPr CD3 H CD3 4411 H H iPr CD3 H CH3 4412 H H iPr CD3 H H 4413 H H iPr CH3 CD3 H 4414 H H iPr CH3 CH3 H 4415 H H iPr CH3 H CD3 4416 H H iPr CH3 H CH3 4417 H H iPr CH3 H H 4418 H H iPr H CD3 CD3 4419 H H iPr H CD3 CH3 4420 H H iPr H CD3 H 4421 H H iPr H CH3 CD3 4422 H H iPr H CH3 CH3 4423 H H iPr H CH3 H 4424 H H iPr H H CD3 4425 H H iPr H H CH3 4426 H H iPr H H H 4427 H ph H CD3 H H 4428 H ph H CH3 H H 4429 H ph H H CD3 H 4430 H ph H H CH3 H 4431 H ph H H H CD3 4432 H ph H H H CH3 4433 H ph H H H H 4434 iPr CD3 H H H H 4435 iPr CH3 H H H H 4436 iPr H CD3 H H H 4437 iPr H CH3 H H H 4438 iPr H H CD3 H H 4439 iPr H H CH3 H H 4440 iPr H H H CD3 H 4441 iPr H H H CH3 H 4442 iPr H H H H CD3 4443 iPr H H H H CH3 4444 iPr H H H H H LA4445 to LA4872 based on structure:

LA # R11 R2 R12 R32 R33 R34 4445 CD3 CD3 2,6DIP H H H 4446 CD3 CD3 2,6DMB H H H 4447 CD3 CD3 CD3 H H H 4448 CD3 CD3 CH3 H H H 4449 CD3 CD3 H H H H 4450 CD3 CD3 iPr H H H 4451 CD3 CH3 2,6DIP H H H 4452 CD3 CH3 2,6DMB H H H 4453 CD3 CH3 CD3 H H H 4454 CD3 CH3 CH3 H H H 4455 CD3 CH3 H H H H 4456 CD3 CH3 iPr H H H 4457 CD3 H 2,6DIP CD3 H H 4458 CD3 H 2,6DIP CH3 H H 4459 CD3 H 2,6DIP H CD3 H 4460 CD3 H 2,6DIP H CH3 H 4461 CD3 H 2,6DIP H H CD3 4462 CD3 H 2,6DIP H H CH3 4463 CD3 H 2,6DIP H H H 4464 CD3 H 2,6DMB CD3 H H 4465 CD3 H 2,6DMB CH3 H H 4466 CD3 H 2,6DMB H CD3 H 4467 CD3 H 2,6DMB H CH3 H 4468 CD3 H 2,6DMB H H CD3 4469 CD3 H 2,6DMB H H CH3 4470 CD3 H 2,6DMB H H H 4471 CD3 H CD3 CD3 H H 4472 CD3 H CD3 CH3 H H 4473 CD3 H CD3 H CD3 H 4474 CD3 H CD3 H CH3 H 4475 CD3 H CD3 H H CD3 4476 CD3 H CD3 H H CH3 4477 CD3 H CD3 H H H 4478 CD3 H CH3 CD3 H H 4479 CD3 H CH3 CH3 H H 4480 CD3 H CH3 H CD3 H 4481 CD3 H CH3 H CH3 H 4482 CD3 H CH3 H H CD3 4483 CD3 H CH3 H H CH3 4484 CD3 H CH3 H H H 4485 CD3 H H 2,6DIP H H 4486 CD3 H H 2,6DMB H H 4487 CD3 H H CD3 H H 4488 CD3 H H CH3 H H 4489 CD3 H H H 2,6DIP H 4490 CD3 H H H 2,6DMB H 4491 CD3 H H H CD3 H 4492 CD3 H H H CH3 H 4493 CD3 H H H H 2,6DIP 4494 CD3 H H H H 2,6DMB 4495 CD3 H H H H CD3 4496 CD3 H H H H CH3 4497 CD3 H H H H H 4498 CD3 H H H H iPr 4499 CD3 H H H iPr H 4500 CD3 H H iPr H H 4501 CD3 H iPr CD3 H H 4502 CD3 H iPr CH3 H H 4503 CD3 H iPr H CD3 H 4504 CD3 H iPr H CH3 H 4505 CD3 H iPr H H CD3 4506 CD3 H iPr H H CH3 4507 CD3 H iPr H H H 4508 CH3 CD3 2,6DIP H H H 4509 CH3 CD3 2,6DMB H H H 4510 CH3 CD3 CD3 H H H 4511 CH3 CD3 CH3 H H H 4512 CH3 CD3 H H H H 4513 CH3 CD3 iPr H H H 4514 CH3 CH3 2,6DIP H H H 4515 CH3 CH3 2,6DMB H H H 4516 CH3 CH3 CD3 H H H 4517 CH3 CH3 CH3 H H H 4518 CH3 CH3 H H H H 4519 CH3 CH3 iPr H H H 4520 CH3 H 2,6DIP CD3 H H 4521 CH3 H 2,6DIP CH3 H H 4522 CH3 H 2,6DIP H CD3 H 4523 CH3 H 2,6DIP H CH3 H 4524 CH3 H 2,6DIP H H CD3 4525 CH3 H 2,6DIP H H CH3 4526 CH3 H 2,6DIP H H H 4527 CH3 H 2,6DMB CD3 H H 4528 CH3 H 2,6DMB CH3 H H 4529 CH3 H 2,6DMB H CD3 H 4530 CH3 H 2,6DMB H CH3 H 4531 CH3 H 2,6DMB H H CD3 4532 CH3 H 2,6DMB H H CH3 4533 CH3 H 2,6DMB H H H 4534 CH3 H CD3 CD3 H H 4535 CH3 H CD3 CH3 H H 4536 CH3 H CD3 H CD3 H 4537 CH3 H CD3 H CH3 H 4538 CH3 H CD3 H H CD3 4539 CH3 H CD3 H H CH3 4540 CH3 H CD3 H H H 4541 CH3 H CH3 CD3 H H 4542 CH3 H CH3 CH3 H H 4543 CH3 H CH3 H CD3 H 4544 CH3 H CH3 H CH3 H 4545 CH3 H CH3 H H CD3 4546 CH3 H CH3 H H CH3 4547 CH3 H CH3 H H H 4548 CH3 H H 2,6DIP H H 4549 CH3 H H 2,6DMB H H 4550 CH3 H H CD3 H H 4551 CH3 H H CH3 H H 4552 CH3 H H H 2,6DIP H 4553 CH3 H H H 2,6DMB H 4554 CH3 H H H CD3 H 4555 CH3 H H H CH3 H 4556 CH3 H H H H 2,6DIP 4557 CH3 H H H H 2,6DMB 4558 CH3 H H H H CD3 4559 CH3 H H H H CH3 4560 CH3 H H H H H 4561 CH3 H H H H iPr 4562 CH3 H H H iPr H 4563 CH3 H H iPr H H 4564 CH3 H iPr CD3 H H 4565 CH3 H iPr CH3 H H 4566 CH3 H iPr H CD3 H 4567 CH3 H iPr H CH3 H 4568 CH3 H iPr H H CD3 4569 CH3 H iPr H H CH3 4570 CH3 H iPr H H H 4571 H 2,6DIP H CD3 H H 4572 H 2,6DIP H CH3 H H 4573 H 2,6DIP H H CD3 H 4574 H 2,6DIP H H CH3 H 4575 H 2,6DIP H H H CD3 4576 H 2,6DIP H H H CH3 4577 H 2,6DIP H H H H 4578 H 2,6DIPB H CD3 H H 4579 H 2,6DIPB H CH3 H H 4580 H 2,6DIPB H H CD3 H 4581 H 2,6DIPB H H CH3 H 4582 H 2,6DIPB H H H CD3 4583 H 2,6DIPB H H H CH3 4584 H 2,6DIPB H H H H 4585 H 2,6DMB H CD3 H H 4586 H 2,6DMB H CH3 H H 4587 H 2,6DMB H H CD3 H 4588 H 2,6DMB H H CH3 H 4589 H 2,6DMB H H H CD3 4590 H 2,6DMB H H H CH3 4591 H 2,6DMB H H H H 4592 H CD3 2,6DIP CD3 H H 4593 H CD3 2,6DIP CH3 H H 4594 H CD3 2,6DIP H CD3 H 4595 H CD3 2,6DIP H CH3 H 4596 H CD3 2,6DIP H H CD3 4597 H CD3 2,6DIP H H CH3 4598 H CD3 2,6DIP H H H 4599 H CD3 2,6DMB CD3 H H 4600 H CD3 2,6DMB CH3 H H 4601 H CD3 2,6DMB H CD3 H 4602 H CD3 2,6DMB H CH3 H 4603 H CD3 2,6DMB H H CD3 4604 H CD3 2,6DMB H H CH3 4605 H CD3 2,6DMB H H H 4606 H CD3 CD3 CD3 H H 4607 H CD3 CD3 CH3 H H 4608 H CD3 CD3 H CD3 H 4609 H CD3 CD3 H CH3 H 4610 H CD3 CD3 H H CD3 4611 H CD3 CD3 H H CH3 4612 H CD3 CD3 H H H 4613 H CD3 CH3 CD3 H H 4614 H CD3 CH3 CH3 H H 4615 H CD3 CH3 H CD3 H 4616 H CD3 CH3 H CH3 H 4617 H CD3 CH3 H H CD3 4618 H CD3 CH3 H H CH3 4619 H CD3 CH3 H H H 4620 H CD3 H 2,6DIP H H 4621 H CD3 H 2,6DMB H H 4622 H CD3 H CD3 H H 4623 H CD3 H CH3 H H 4624 H CD3 H H 2,6DIP H 4625 H CD3 H H 2,6DMB H 4626 H CD3 H H CD3 H 4627 H CD3 H H CH3 H 4628 H CD3 H H H 2,6DIP 4629 H CD3 H H H 2,6DMB 4630 H CD3 H H H CD3 4631 H CD3 H H H CH3 4632 H CD3 H H H H 4633 H CD3 H H H iPr 4634 H CD3 H H iPr H 4635 H CD3 H iPr H H 4636 H CD3 iPr CD3 H H 4637 H CD3 iPr CH3 H H 4638 H CD3 iPr H CD3 H 4639 H CD3 iPr H CH3 H 4640 H CD3 iPr H H CD3 4641 H CD3 iPr H H CH3 4642 H CD3 iPr H H H 4643 H CH3 2,6DIP CD3 H H 4644 H CH3 2,6DIP CH3 H H 4645 H CH3 2,6DIP H CD3 H 4646 H CH3 2,6DIP H CH3 H 4647 H CH3 2,6DIP H H CD3 4648 H CH3 2,6DIP H H CH3 4649 H CH3 2,6DIP H H H 4650 H CH3 2,6DMB CD3 H H 4651 H CH3 2,6DMB CH3 H H 4652 H CH3 2,6DMB H CD3 H 4653 H CH3 2,6DMB H CH3 H 4654 H CH3 2,6DMB H H CD3 4655 H CH3 2,6DMB H H CH3 4656 H CH3 2,6DMB H H H 4657 H CH3 CD3 CD3 H H 4658 H CH3 CD3 CH3 H H 4659 H CH3 CD3 H CD3 H 4660 H CH3 CD3 H CH3 H 4661 H CH3 CD3 H H CD3 4662 H CH3 CD3 H H CH3 4663 H CH3 CD3 H H H 4664 H CH3 CH3 CD3 H H 4665 H CH3 CH3 CH3 H H 4666 H CH3 CH3 H CD3 H 4667 H CH3 CH3 H CH3 H 4668 H CH3 CH3 H H CD3 4669 H CH3 CH3 H H CH3 4670 H CH3 CH3 H H H 4671 H CH3 H 2,6DIP H H 4672 H CH3 H 2,6DMB H H 4673 H CH3 H CD3 H H 4674 H CH3 H CH3 H H 4675 H CH3 H H 2,6DIP H 4676 H CH3 H H 2,6DMB H 4677 H CH3 H H CD3 H 4678 H CH3 H H CH3 H 4679 H CH3 H H H 2,6DIP 4680 H CH3 H H H 2,6DMB 4681 H CH3 H H H CD3 4682 H CH3 H H H CH3 4683 H CH3 H H H H 4684 H CH3 H H H iPr 4685 H CH3 H H iPr H 4686 H CH3 H iPr H H 4687 H CH3 iPr CD3 H H 4688 H CH3 iPr CH3 H H 4689 H CH3 iPr H CD3 H 4690 H CH3 iPr H CH3 H 4691 H CH3 iPr H H CD3 4692 H CH3 iPr H H CH3 4693 H CH3 iPr H H H 4694 H H 2,6DIP CD3 CD3 H 4695 H H 2,6DIP CD3 CH3 H 4696 H H 2,6DIP CD3 H CD3 4697 H H 2,6DIP CD3 H CH3 4698 H H 2,6DIP CD3 H H 4699 H H 2,6DIP CH3 CD3 H 4700 H H 2,6DIP CH3 CH3 H 4701 H H 2,6DIP CH3 H CD3 4702 H H 2,6DIP CH3 H CH3 4703 H H 2,6DIP CH3 H H 4704 H H 2,6DIP H CD3 CD3 4705 H H 2,6DIP H CD3 CH3 4706 H H 2,6DIP H CD3 H 4707 H H 2,6DIP H CH3 CD3 4708 H H 2,6DIP H CH3 CH3 4709 H H 2,6DIP H CH3 H 4710 H H 2,6DIP H H CD3 4711 H H 2,6DIP H H CH3 4712 H H 2,6DIP H H H 4713 H H 2,6DMB CD3 CD3 H 4714 H H 2,6DMB CD3 CH3 H 4715 H H 2,6DMB CD3 H CD3 4716 H H 2,6DMB CD3 H CH3 4717 H H 2,6DMB CD3 H H 4718 H H 2,6DMB CH3 CD3 H 4719 H H 2,6DMB CH3 CH3 H 4720 H H 2,6DMB CH3 H CD3 4721 H H 2,6DMB CH3 H CH3 4722 H H 2,6DMB CH3 H H 4723 H H 2,6DMB H CD3 CD3 4724 H H 2,6DMB H CD3 CH3 4725 H H 2,6DMB H CD3 H 4726 H H 2,6DMB H CH3 CD3 4727 H H 2,6DMB H CH3 CH3 4728 H H 2,6DMB H CH3 H 4729 H H 2,6DMB H H CD3 4730 H H 2,6DMB H H CH3 4731 H H 2,6DMB H H H 4732 H H CD3 2,6DIP H H 4733 H H CD3 2,6DMB H H 4734 H H CD3 CD3 CD3 H 4735 H H CD3 CD3 CH3 H 4736 H H CD3 CD3 H CD3 4737 H H CD3 CD3 H CH3 4738 H H CD3 CD3 H H 4739 H H CD3 CH3 CD3 H 4740 H H CD3 CH3 CH3 H 4741 H H CD3 CH3 H CD3 4742 H H CD3 CH3 H CH3 4743 H H CD3 CH3 H H 4744 H H CD3 H 2,6DIP H 4745 H H CD3 H 2,6DMB H 4746 H H CD3 H CD3 CD3 4747 H H CD3 H CD3 CH3 4748 H H CD3 H CD3 H 4749 H H CD3 H CH3 CD3 4750 H H CD3 H CH3 CH3 4751 H H CD3 H CH3 H 4752 H H CD3 H H 2,6DIP 4753 H H CD3 H H 2,6DMB 4754 H H CD3 H H CD3 4755 H H CD3 H H CH3 4756 H H CD3 H H H 4757 H H CD3 H H iPr 4758 H H CD3 H iPr H 4759 H H CD3 iPr H H 4760 H H CH3 2,6DIP H H 4761 H H CH3 2,6DMB H H 4762 H H CH3 CD3 CD3 H 4763 H H CH3 CD3 CH3 H 4764 H H CH3 CD3 H CD3 4765 H H CH3 CD3 H CH3 4766 H H CH3 CD3 H H 4767 H H CH3 CH3 CD3 H 4768 H H CH3 CH3 CH3 H 4769 H H CH3 CH3 H CD3 4770 H H CH3 CH3 H CH3 4771 H H CH3 CH3 H H 4772 H H CH3 H 2,6DIP H 4773 H H CH3 H 2,6DMB H 4774 H H CH3 H CD3 CD3 4775 H H CH3 H CD3 CH3 4776 H H CH3 H CD3 H 4777 H H CH3 H CH3 CD3 4778 H H CH3 H CH3 CH3 4779 H H CH3 H CH3 H 4780 H H CH3 H H 2,6DIP 4781 H H CH3 H H 2,6DMB 4782 H H CH3 H H CD3 4783 H H CH3 H H CH3 4784 H H CH3 H H H 4785 H H CH3 H H iPr 4786 H H CH3 H iPr H 4787 H H CH3 iPr H H 4788 H H H 2,6DIP H CD3 4789 H H H 2,6DIP H CH3 4790 H H H 2,6DIP H H 4791 H H H 2,6DMB H CD3 4792 H H H 2,6DMB H CH3 4793 H H H 2,6DMB H H 4794 H H H CD3 CD3 H 4795 H H H CD3 CH3 H 4796 H H H CD3 H 2,6DIP 4797 H H H CD3 H 2,6DMB 4798 H H H CD3 H CD3 4799 H H H CD3 H CH3 4800 H H H CD3 H H 4801 H H H CD3 H iPr 4802 H H H CD3 iPr H 4803 H H H CH3 CD3 H 4804 H H H CH3 CH3 H 4805 H H H CH3 H 2,6DIP 4806 H H H CH3 H 2,6DMB 4807 H H H CH3 H CD3 4808 H H H CH3 H CH3 4809 H H H CH3 H H 4810 H H H CH3 H iPr 4811 H H H CH3 iPr H 4812 H H H H 2,6DIP H 4813 H H H H 2,6DMB H 4814 H H H H CD3 CD3 4815 H H H H CD3 CH3 4816 H H H H CD3 H 4817 H H H H CD3 iPr 4818 H H H H CH3 CD3 4819 H H H H CH3 CH3 4820 H H H H CH3 H 4821 H H H H CH3 iPr 4822 H H H H H 2,6DIP 4823 H H H H H 2,6DMB 4824 H H H H H CD3 4825 H H H H H CH3 4826 H H H H H H 4827 H H H H H iPr 4828 H H H H iPr CD3 4829 H H H H iPr CH3 4830 H H H H iPr H 4831 H H H iPr CD3 H 4832 H H H iPr CH3 H 4833 H H H iPr H CD3 4834 H H H iPr H CH3 4835 H H H iPr H H 4836 H H iPr CD3 CD3 H 4837 H H iPr CD3 CH3 H 4838 H H iPr CD3 H CD3 4839 H H iPr CD3 H CH3 4840 H H iPr CD3 H H 4841 H H iPr CH3 CD3 H 4842 H H iPr CH3 CH3 H 4843 H H iPr CH3 H CD3 4844 H H iPr CH3 H CH3 4845 H H iPr CH3 H H 4846 H H iPr H CD3 CD3 4847 H H iPr H CD3 CH3 4848 H H iPr H CD3 H 4849 H H iPr H CH3 CD3 4850 H H iPr H CH3 CH3 4851 H H iPr H CH3 H 4852 H H iPr H H CD3 4853 H H iPr H H CH3 4854 H H iPr H H H 4855 H ph H CD3 H H 4856 H ph H CH3 H H 4857 H ph H H CD3 H 4858 H ph H H CH3 H 4859 H ph H H H CD3 4860 H ph H H H CH3 4861 H ph H H H H 4862 iPr CD3 H H H H 4863 iPr CH3 H H H H 4864 iPr H CD3 H H H 4865 iPr H CH3 H H H 4866 iPr H H CD3 H H 4867 iPr H H CH3 H H 4868 iPr H H H CD3 H 4869 iPr H H H CH3 H 4870 iPr H H H H CD3 4871 iPr H H H H CH3 4872 iPr H H H H H LA4873 to LA5487 based on structure:

LA # R11 R12 R2 R31 R32 R33 R34 4873 CD3 CD3 2,6DIP H H H H 4874 CD3 CD3 2,6DMB H H H H 4875 CD3 CD3 CD3 H H H H 4876 CD3 CD3 CH3 H H H H 4877 CD3 CD3 H H H H H 4878 CD3 CD3 iPr H H H H 4879 CD3 CH3 2,6DIP H H H H 4880 CD3 CH3 2,6DMB H H H H 4881 CD3 CH3 CD3 H H H H 4882 CD3 CH3 CH3 H H H H 4883 CD3 CH3 H H H H H 4884 CD3 CH3 iPr H H H H 4885 CD3 H 2,6DIP CD3 H H H 4886 CD3 H 2,6DIP CH3 H H H 4887 CD3 H 2,6DIP H CD3 H H 4888 CD3 H 2,6DIP H CH3 H H 4889 CD3 H 2,6DIP H H CD3 H 4890 CD3 H 2,6DIP H H CH3 H 4891 CD3 H 2,6DIP H H H CD3 4892 CD3 H 2,6DIP H H H CH3 4893 CD3 H 2,6DIP H H H H 4894 CD3 H 2,6DMB CD3 H H H 4895 CD3 H 2,6DMB CH3 H H H 4896 CD3 H 2,6DMB H CD3 H H 4897 CD3 H 2,6DMB H CH3 H H 4898 CD3 H 2,6DMB H H CD3 H 4899 CD3 H 2,6DMB H H CH3 H 4900 CD3 H 2,6DMB H H H CD3 4901 CD3 H 2,6DMB H H H CH3 4902 CD3 H 2,6DMB H H H H 4903 CD3 H CD3 CD3 H H H 4904 CD3 H CD3 CH3 H H H 4905 CD3 H CD3 H CD3 H H 4906 CD3 H CD3 H CH3 H H 4907 CD3 H CD3 H H CD3 H 4908 CD3 H CD3 H H CH3 H 4909 CD3 H CD3 H H H CD3 4910 CD3 H CD3 H H H CH3 4911 CD3 H CD3 H H H H 4912 CD3 H CH3 CD3 H H H 4913 CD3 H CH3 CH3 H H H 4914 CD3 H CH3 H CD3 H H 4915 CD3 H CH3 H CH3 H H 4916 CD3 H CH3 H H CD3 H 4917 CD3 H CH3 H H CH3 H 4918 CD3 H CH3 H H H CD3 4919 CD3 H CH3 H H H CH3 4920 CD3 H CH3 H H H H 4921 CD3 H H 2,6DIP H H H 4922 CD3 H H 2,6DMB H H H 4923 CD3 H H CD3 H H H 4924 CD3 H H CH3 H H H 4925 CD3 H H H 2,6DIP H H 4926 CD3 H H H 2,6DMB H H 4927 CD3 H H H CD3 H H 4928 CD3 H H H CH3 H H 4929 CD3 H H H H 2,6DIP H 4930 CD3 H H H H 2,6DMB H 4931 CD3 H H H H CD3 H 4932 CD3 H H H H CH3 H 4933 CD3 H H H H H 2,6DIP 4934 CD3 H H H H H 2,6DMB 4935 CD3 H H H H H CD3 4936 CD3 H H H H H CH3 4937 CD3 H H H H H H 4938 CD3 H H H H H iPr 4939 CD3 H H H H iPr H 4940 CD3 H H H iPr H H 4941 CD3 H H iPr H H H 4942 CD3 H iPr CD3 H H H 4943 CD3 H iPr CH3 H H H 4944 CD3 H iPr H CD3 H H 4945 CD3 H iPr H CH3 H H 4946 CD3 H iPr H H CD3 H 4947 CD3 H iPr H H CH3 H 4948 CD3 H iPr H H H CD3 4949 CD3 H iPr H H H CH3 4950 CD3 H iPr H H H H 4951 CH3 CD3 2,6DIP H H H H 4952 CH3 CD3 2,6DMB H H H H 4953 CH3 CD3 CD3 H H H H 4954 CH3 CD3 CH3 H H H H 4955 CH3 CD3 H H H H H 4956 CH3 CD3 iPr H H H H 4957 CH3 CH3 2,6DIP H H H H 4958 CH3 CH3 2,6DMB H H H H 4959 CH3 CH3 CD3 H H H H 4960 CH3 CH3 CH3 H H H H 4961 CH3 CH3 H H H H H 4962 CH3 CH3 iPr H H H H 4963 CH3 H 2,6DIP CD3 H H H 4964 CH3 H 2,6DIP CH3 H H H 4965 CH3 H 2,6DIP H CD3 H H 4966 CH3 H 2,6DIP H CH3 H H 4967 CH3 H 2,6DIP H H CD3 H 4968 CH3 H 2,6DIP H H CH3 H 4969 CH3 H 2,6DIP H H H CD3 4970 CH3 H 2,6DIP H H H CH3 4971 CH3 H 2,6DIP H H H H 4972 CH3 H 2,6DMB CD3 H H H 4973 CH3 H 2,6DMB CH3 H H H 4974 CH3 H 2,6DMB H CD3 H H 4975 CH3 H 2,6DMB H CH3 H H 4976 CH3 H 2,6DMB H H CD3 H 4977 CH3 H 2,6DMB H H CH3 H 4978 CH3 H 2,6DMB H H H CD3 4979 CH3 H 2,6DMB H H H CH3 4980 CH3 H 2,6DMB H H H H 4981 CH3 H CD3 CD3 H H H 4982 CH3 H CD3 CH3 H H H 4983 CH3 H CD3 H CD3 H H 4984 CH3 H CD3 H CH3 H H 4985 CH3 H CD3 H H CD3 H 4986 CH3 H CD3 H H CH3 H 4987 CH3 H CD3 H H H CD3 4988 CH3 H CD3 H H H CH3 4989 CH3 H CD3 H H H H 4990 CH3 H CH3 CD3 H H H 4991 CH3 H CH3 CH3 H H H 4992 CH3 H CH3 H CD3 H H 4993 CH3 H CH3 H CH3 H H 4994 CH3 H CH3 H H CD3 H 4995 CH3 H CH3 H H CH3 H 4996 CH3 H CH3 H H H CD3 4997 CH3 H CH3 H H H CH3 4998 CH3 H CH3 H H H H 4999 CH3 H H 2,6DIP H H H 5000 CH3 H H 2,6DMB H H H 5001 CH3 H H CD3 H H H 5002 CH3 H H CH3 H H H 5003 CH3 H H H 2,6DIP H H 5004 CH3 H H H 2,6DMB H H 5005 CH3 H H H CD3 H H 5006 CH3 H H H CH3 H H 5007 CH3 H H H H 2,6DIP H 5008 CH3 H H H H 2,6DMB H 5009 CH3 H H H H CD3 H 5010 CH3 H H H H CH3 H 5011 CH3 H H H H H 2,6DIP 5012 CH3 H H H H H 2,6DMB 5013 CH3 H H H H H CD3 5014 CH3 H H H H H CH3 5015 CH3 H H H H H H 5016 CH3 H H H H H iPr 5017 CH3 H H H H iPr H 5018 CH3 H H H iPr H H 5019 CH3 H H iPr H H H 5020 CH3 H iPr CD3 H H H 5021 CH3 H iPr CH3 H H H 5022 CH3 H iPr H CD3 H H 5023 CH3 H iPr H CH3 H H 5024 CH3 H iPr H H CD3 H 5025 CH3 H iPr H H CH3 H 5026 CH3 H iPr H H H CD3 5027 CH3 H iPr H H H CH3 5028 CH3 H iPr H H H H 5029 H 2,6DIP H CD3 H H H 5030 H 2,6DIP H CH3 H H H 5031 H 2,6DIP H H CD3 H H 5032 H 2,6DIP H H CH3 H H 5033 H 2,6DIP H H H CD3 H 5034 H 2,6DIP H H H CH3 H 5035 H 2,6DIP H H H H CD3 5036 H 2,6DIP H H H H CH3 5037 H 2,6DIP H H H H H 5038 H 2,6DIPB H CD3 H H H 5039 H 2,6DIPB H CH3 H H H 5040 H 2,6DIPB H H CD3 H H 5041 H 2,6DIPB H H CH3 H H 5042 H 2,6DIPB H H H CD3 H 5043 H 2,6DIPB H H H CH3 H 5044 H 2,6DIPB H H H H CD3 5045 H 2,6DIPB H H H H CH3 5046 H 2,6DIPB H H H H H 5047 H 2,6DMB H CD3 H H H 5048 H 2,6DMB H CH3 H H H 5049 H 2,6DMB H H CD3 H H 5050 H 2,6DMB H H CH3 H H 5051 H 2,6DMB H H H CD3 H 5052 H 2,6DMB H H H CH3 H 5053 H 2,6DMB H H H H CD3 5054 H 2,6DMB H H H H CH3 5055 H 2,6DMB H H H H H 5056 H CD3 2,6DIP CD3 H H H 5057 H CD3 2,6DIP CH3 H H H 5058 H CD3 2,6DIP H CD3 H H 5059 H CD3 2,6DIP H CH3 H H 5060 H CD3 2,6DIP H H CD3 H 5061 H CD3 2,6DIP H H CH3 H 5062 H CD3 2,6DIP H H H CD3 5063 H CD3 2,6DIP H H H CH3 5064 H CD3 2,6DIP H H H H 5065 H CD3 2,6DMB CD3 H H H 5066 H CD3 2,6DMB CH3 H H H 5067 H CD3 2,6DMB H CD3 H H 5068 H CD3 2,6DMB H CH3 H H 5069 H CD3 2,6DMB H H CD3 H 5070 H CD3 2,6DMB H H CH3 H 5071 H CD3 2,6DMB H H H CD3 5072 H CD3 2,6DMB H H H CH3 5073 H CD3 2,6DMB H H H H 5074 H CD3 CD3 CD3 H H H 5075 H CD3 CD3 CH3 H H H 5076 H CD3 CD3 H CD3 H H 5077 H CD3 CD3 H CH3 H H 5078 H CD3 CD3 H H CD3 H 5079 H CD3 CD3 H H CH3 H 5080 H CD3 CD3 H H H CD3 5081 H CD3 CD3 H H H CH3 5082 H CD3 CD3 H H H H 5083 H CD3 CH3 CD3 H H H 5084 H CD3 CH3 CH3 H H H 5085 H CD3 CH3 H CD3 H H 5086 H CD3 CH3 H CH3 H H 5087 H CD3 CH3 H H CD3 H 5088 H CD3 CH3 H H CH3 H 5089 H CD3 CH3 H H H CD3 5090 H CD3 CH3 H H H CH3 5091 H CD3 CH3 H H H H 5092 H CD3 H 2,6DIP H H H 5093 H CD3 H 2,6DMB H H H 5094 H CD3 H CD3 H H H 5095 H CD3 H CH3 H H H 5096 H CD3 H H 2,6DIP H H 5097 H CD3 H H 2,6DMB H H 5098 H CD3 H H CD3 H H 5099 H CD3 H H CH3 H H 5100 H CD3 H H H 2,6DIP H 5101 H CD3 H H H 2,6DMB H 5102 H CD3 H H H CD3 H 5103 H CD3 H H H CH3 H 5104 H CD3 H H H H 2,6DIP 5105 H CD3 H H H H 2,6DMB 5106 H CD3 H H H H CD3 5107 H CD3 H H H H CH3 5108 H CD3 H H H H H 5109 H CD3 H H H H iPr 5110 H CD3 H H H iPr H 5111 H CD3 H H iPr H H 5112 H CD3 H iPr H H H 5113 H CD3 iPr CD3 H H H 5114 H CD3 iPr CH3 H H H 5115 H CD3 iPr H CD3 H H 5116 H CD3 iPr H CH3 H H 5117 H CD3 iPr H H CD3 H 5118 H CD3 iPr H H CH3 H 5119 H CD3 iPr H H H CD3 5120 H CD3 iPr H H H CH3 5121 H CD3 iPr H H H H 5122 H CH3 2,6DIP CD3 H H H 5123 H CH3 2,6DIP CH3 H H H 5124 H CH3 2,6DIP H CD3 H H 5125 H CH3 2,6DIP H CH3 H H 5126 H CH3 2,6DIP H H CD3 H 5127 H CH3 2,6DIP H H CH3 H 5128 H CH3 2,6DIP H H H CD3 5129 H CH3 2,6DIP H H H CH3 5130 H CH3 2,6DIP H H H H 5131 H CH3 2,6DMB CD3 H H H 5132 H CH3 2,6DMB CH3 H H H 5133 H CH3 2,6DMB H CD3 H H 5134 H CH3 2,6DMB H CH3 H H 5135 H CH3 2,6DMB H H CD3 H 5136 H CH3 2,6DMB H H CH3 H 5137 H CH3 2,6DMB H H H CD3 5138 H CH3 2,6DMB H H H CH3 5139 H CH3 2,6DMB H H H H 5140 H CH3 CD3 CD3 H H H 5141 H CH3 CD3 CH3 H H H 5142 H CH3 CD3 H CD3 H H 5143 H CH3 CD3 H CH3 H H 5144 H CH3 CD3 H H CD3 H 5145 H CH3 CD3 H H CH3 H 5146 H CH3 CD3 H H H CD3 5147 H CH3 CD3 H H H CH3 5148 H CH3 CD3 H H H H 5149 H CH3 CH3 CD3 H H H 5150 H CH3 CH3 CH3 H H H 5151 H CH3 CH3 H CD3 H H 5152 H CH3 CH3 H CH3 H H 5153 H CH3 CH3 H H CD3 H 5154 H CH3 CH3 H H CH3 H 5155 H CH3 CH3 H H H CD3 5156 H CH3 CH3 H H H CH3 5157 H CH3 CH3 H H H H 5158 H CH3 H 2,6DIP H H H 5159 H CH3 H 2,6DMB H H H 5160 H CH3 H CD3 H H H 5161 H CH3 H CH3 H H H 5162 H CH3 H H 2,6DIP H H 5163 H CH3 H H 2,6DMB H H 5164 H CH3 H H CD3 H H 5165 H CH3 H H CH3 H H 5166 H CH3 H H H 2,6DIP H 5167 H CH3 H H H 2,6DMB H 5168 H CH3 H H H CD3 H 5169 H CH3 H H H CH3 H 5170 H CH3 H H H H 2,6DIP 5171 H CH3 H H H H 2,6DMB 5172 H CH3 H H H H CD3 5173 H CH3 H H H H CH3 5174 H CH3 H H H H H 5175 H CH3 H H H H iPr 5176 H CH3 H H H iPr H 5177 H CH3 H H iPr H H 5178 H CH3 H iPr H H H 5179 H CH3 iPr CD3 H H H 5180 H CH3 iPr CH3 H H H 5181 H CH3 iPr H CD3 H H 5182 H CH3 iPr H CH3 H H 5183 H CH3 iPr H H CD3 H 5184 H CH3 iPr H H CH3 H 5185 H CH3 iPr H H H CD3 5186 H CH3 iPr H H H CH3 5187 H CH3 iPr H H H H 5188 H H 2,6DIP CD3 CD3 H H 5189 H H 2,6DIP CD3 CH3 H H 5190 H H 2,6DIP CD3 H CD3 H 5191 H H 2,6DIP CD3 H CH3 H 5192 H H 2,6DIP CD3 H H CD3 5193 H H 2,6DIP CD3 H H CH3 5194 H H 2,6DIP CD3 H H H 5195 H H 2,6DIP CH3 CD3 H H 5196 H H 2,6DIP CH3 CH3 H H 5197 H H 2,6DIP CH3 H CD3 H 5198 H H 2,6DIP CH3 H CH3 H 5199 H H 2,6DIP CH3 H H CD3 5200 H H 2,6DIP CH3 H H CH3 5201 H H 2,6DIP CH3 H H H 5202 H H 2,6DIP H CD3 CD3 H 5203 H H 2,6DIP H CD3 CH3 H 5204 H H 2,6DIP H CD3 H CD3 5205 H H 2,6DIP H CD3 H CH3 5206 H H 2,6DIP H CD3 H H 5207 H H 2,6DIP H CH3 CD3 H 5208 H H 2,6DIP H CH3 CH3 H 5209 H H 2,6DIP H CH3 H CD3 5210 H H 2,6DIP H CH3 H CH3 5211 H H 2,6DIP H CH3 H H 5212 H H 2,6DIP H H CD3 CD3 5213 H H 2,6DIP H H CD3 CH3 5214 H H 2,6DIP H H CD3 H 5215 H H 2,6DIP H H CH3 CD3 5216 H H 2,6DIP H H CH3 CH3 5217 H H 2,6DIP H H CH3 H 5218 H H 2,6DIP H H H CD3 5219 H H 2,6DIP H H H CH3 5220 H H 2,6DIP H H H H 5221 H H 2,6DMB CD3 CD3 H H 5222 H H 2,6DMB CD3 CH3 H H 5223 H H 2,6DMB CD3 H CD3 H 5224 H H 2,6DMB CD3 H CH3 H 5225 H H 2,6DMB CD3 H H CD3 5226 H H 2,6DMB CD3 H H CH3 5227 H H 2,6DMB CD3 H H H 5228 H H 2,6DMB CH3 CD3 H H 5229 H H 2,6DMB CH3 CH3 H H 5230 H H 2,6DMB CH3 H CD3 H 5231 H H 2,6DMB CH3 H CH3 H 5232 H H 2,6DMB CH3 H H CD3 5233 H H 2,6DMB CH3 H H CH3 5234 H H 2,6DMB CH3 H H H 5235 H H 2,6DMB H CD3 CD3 H 5236 H H 2,6DMB H CD3 CH3 H 5237 H H 2,6DMB H CD3 H CD3 5238 H H 2,6DMB H CD3 H CH3 5239 H H 2,6DMB H CD3 H H 5240 H H 2,6DMB H CH3 CD3 H 5241 H H 2,6DMB H CH3 CH3 H 5242 H H 2,6DMB H CH3 H CD3 5243 H H 2,6DMB H CH3 H CH3 5244 H H 2,6DMB H CH3 H H 5245 H H 2,6DMB H H CD3 CD3 5246 H H 2,6DMB H H CD3 CH3 5247 H H 2,6DMB H H CD3 H 5248 H H 2,6DMB H H CH3 CD3 5249 H H 2,6DMB H H CH3 CH3 5250 H H 2,6DMB H H CH3 H 5251 H H 2,6DMB H H H CD3 5252 H H 2,6DMB H H H CH3 5253 H H 2,6DMB H H H H 5254 H H CD3 CD3 CD3 H H 5255 H H CD3 CD3 CH3 H H 5256 H H CD3 CD3 H CD3 H 5257 H H CD3 CD3 H CH3 H 5258 H H CD3 CD3 H H CD3 5259 H H CD3 CD3 H H CH3 5260 H H CD3 CD3 H H H 5261 H H CD3 CH3 CD3 H H 5262 H H CD3 CH3 CH3 H H 5263 H H CD3 CH3 H CD3 H 5264 H H CD3 CH3 H CH3 H 5265 H H CD3 CH3 H H CD3 5266 H H CD3 CH3 H H CH3 5267 H H CD3 CH3 H H H 5268 H H CD3 H 2,6DIP H H 5269 H H CD3 H 2,6DMB H H 5270 H H CD3 H CD3 CD3 H 5271 H H CD3 H CD3 CH3 H 5272 H H CD3 H CD3 H CD3 5273 H H CD3 H CD3 H CH3 5274 H H CD3 H CD3 H H 5275 H H CD3 H CH3 CD3 H 5276 H H CD3 H CH3 CH3 H 5277 H H CD3 H CH3 H CD3 5278 H H CD3 H CH3 H CH3 5279 H H CD3 H CH3 H H 5280 H H CD3 H H 2,6DIP H 5281 H H CD3 H H 2,6DMB H 5282 H H CD3 H H CD3 CD3 5283 H H CD3 H H CD3 CH3 5284 H H CD3 H H CD3 H 5285 H H CD3 H H CH3 CD3 5286 H H CD3 H H CH3 CH3 5287 H H CD3 H H CH3 H 5288 H H CD3 H H H 2,6DIP 5289 H H CD3 H H H 2,6DMB 5290 H H CD3 H H H CD3 5291 H H CD3 H H H CH3 5292 H H CD3 H H H H 5293 H H CD3 H H H iPr 5294 H H CD3 H H iPr H 5295 H H CD3 H iPr H H 5296 H H CD3 iPr H H H 5297 H H CH3 CD3 CD3 H H 5298 H H CH3 CD3 CH3 H H 5299 H H CH3 CD3 H CD3 H 5300 H H CH3 CD3 H CH3 H 5301 H H CH3 CD3 H H CD3 5302 H H CH3 CD3 H H CH3 5303 H H CH3 CD3 H H H 5304 H H CH3 CH3 CD3 H H 5305 H H CH3 CH3 CH3 H H 5306 H H CH3 CH3 H CD3 H 5307 H H CH3 CH3 H CH3 H 5308 H H CH3 CH3 H H CD3 5309 H H CH3 CH3 H H CH3 5310 H H CH3 CH3 H H H 5311 H H CH3 H 2,6DIP H H 5312 H H CH3 H 2,6DMB H H 5313 H H CH3 H CD3 CD3 H 5314 H H CH3 H CD3 CH3 H 5315 H H CH3 H CD3 H CD3 5316 H H CH3 H CD3 H CH3 5317 H H CH3 H CD3 H H 5318 H H CH3 H CH3 CD3 H 5319 H H CH3 H CH3 CH3 H 5320 H H CH3 H CH3 H CD3 5321 H H CH3 H CH3 H CH3 5322 H H CH3 H CH3 H H 5323 H H CH3 H H 2,6DIP H 5324 H H CH3 H H 2,6DMB H 5325 H H CH3 H H CD3 CD3 5326 H H CH3 H H CD3 CH3 5327 H H CH3 H H CD3 H 5328 H H CH3 H H CH3 CD3 5329 H H CH3 H H CH3 CH3 5330 H H CH3 H H CH3 H 5331 H H CH3 H H H 2,6DIP 5332 H H CH3 H H H 2,6DMB 5333 H H CH3 H H H CD3 5334 H H CH3 H H H CH3 5335 H H CH3 H H H H 5336 H H CH3 H H H iPr 5337 H H CH3 H H iPr H 5338 H H CH3 H iPr H H 5339 H H CH3 iPr H H H 5340 H H H 2,6DIP H CD3 H 5341 H H H 2,6DIP H CH3 H 5342 H H H 2,6DIP H H CD3 5343 H H H 2,6DIP H H CH3 5344 H H H 2,6DIP H H H 5345 H H H 2,6DMB H CD3 H 5346 H H H 2,6DMB H CH3 H 5347 H H H 2,6DMB H H CD3 5348 H H H 2,6DMB H H CH3 5349 H H H 2,6DMB H H H 5350 H H H CD3 CD3 H H 5351 H H H CD3 CH3 H H 5352 H H H CD3 H 2,6DIP H 5353 H H H CD3 H 2,6DMB H 5354 H H H CD3 H CD3 H 5355 H H H CD3 H CH3 H 5356 H H H CD3 H H 2,6DIP 5357 H H H CD3 H H 2,6DMB 5358 H H H CD3 H H CD3 5359 H H H CD3 H H CH3 5360 H H H CD3 H H H 5361 H H H CD3 H H iPr 5362 H H H CD3 H iPr H 5363 H H H CD3 iPr H H 5364 H H H CH3 CD3 H H 5365 H H H CH3 CH3 H H 5366 H H H CH3 H 2,6DIP H 5367 H H H CH3 H 2,6DMB H 5368 H H H CH3 H CD3 H 5369 H H H CH3 H CH3 H 5370 H H H CH3 H H 2,6DIP 5371 H H H CH3 H H 2,6DMB 5372 H H H CH3 H H CD3 5373 H H H CH3 H H CH3 5374 H H H CH3 H H H 5375 H H H CH3 H H iPr 5376 H H H CH3 H iPr H 5377 H H H CH3 iPr H H 5378 H H H H 2,6DIP H CD3 5379 H H H H 2,6DIP H CH3 5380 H H H H 2,6DIP H H 5381 H H H H 2,6DMB H CD3 5382 H H H H 2,6DMB H CH3 5383 H H H H 2,6DMB H H 5384 H H H H CD3 CD3 H 5385 H H H H CD3 CH3 H 5386 H H H H CD3 H 2,6DIP 5387 H H H H CD3 H 2,6DMB 5388 H H H H CD3 H CD3 5389 H H H H CD3 H CH3 5390 H H H H CD3 H H 5391 H H H H CD3 H iPr 5392 H H H H CD3 iPr H 5393 H H H H CH3 CD3 H 5394 H H H H CH3 CH3 H 5395 H H H H CH3 H 2,6DIP 5396 H H H H CH3 H 2,6DMB 5397 H H H H CH3 H CD3 5398 H H H H CH3 H CH3 5399 H H H H CH3 H H 5400 H H H H CH3 H iPr 5401 H H H H CH3 iPr H 5402 H H H H H 2,6DIP H 5403 H H H H H 2,6DMB H 5404 H H H H H CD3 CD3 5405 H H H H H CD3 CH3 5406 H H H H H CD3 H 5407 H H H H H CD3 iPr 5408 H H H H H CH3 CD3 5409 H H H H H CH3 CH3 5410 H H H H H CH3 H 5411 H H H H H CH3 iPr 5412 H H H H H H 2,6DIP 5413 H H H H H H 2,6DMB 5414 H H H H H H CD3 5415 H H H H H H CH3 5416 H H H H H H H 5417 H H H H H H iPr 5418 H H H H H iPr CD3 5419 H H H H H iPr CH3 5420 H H H H H iPr H 5421 H H H H iPr CD3 H 5422 H H H H iPr CH3 H 5423 H H H H iPr H CD3 5424 H H H H iPr H CH3 5425 H H H H iPr H H 5426 H H H iPr CD3 H H 5427 H H H iPr CH3 H H 5428 H H H iPr H CD3 H 5429 H H H iPr H CH3 H 5430 H H H iPr H H CD3 5431 H H H iPr H H CH3 5432 H H H iPr H H H 5433 H H iPr CD3 CD3 H H 5434 H H iPr CD3 CH3 H H 5435 H H iPr CD3 H CD3 H 5436 H H iPr CD3 H CH3 H 5437 H H iPr CD3 H H CD3 5438 H H iPr CD3 H H CH3 5439 H H iPr CD3 H H H 5440 H H iPr CH3 CD3 H H 5441 H H iPr CH3 CH3 H H 5442 H H iPr CH3 H CD3 H 5443 H H iPr CH3 H CH3 H 5444 H H iPr CH3 H H CD3 5445 H H iPr CH3 H H CH3 5446 H H iPr CH3 H H H 5447 H H iPr H CD3 CD3 H 5448 H H iPr H CD3 CH3 H 5449 H H iPr H CD3 H CD3 5450 H H iPr H CD3 H CH3 5451 H H iPr H CD3 H H 5452 H H iPr H CH3 CD3 H 5453 H H iPr H CH3 CH3 H 5454 H H iPr H CH3 H CD3 5455 H H iPr H CH3 H CH3 5456 H H iPr H CH3 H H 5457 H H iPr H H CD3 CD3 5458 H H iPr H H CD3 CH3 5459 H H iPr H H CD3 H 5460 H H iPr H H CH3 CD3 5461 H H iPr H H CH3 CH3 5462 H H iPr H H CH3 H 5463 H H iPr H H H CD3 5464 H H iPr H H H CH3 5465 H H iPr H H H H 5466 H ph H CD3 H H H 5467 H ph H CH3 H H H 5468 H ph H H CD3 H H 5469 H ph H H CH3 H H 5470 H ph H H H CD3 H 5471 H ph H H H CH3 H 5472 H ph H H H H CD3 5473 H ph H H H H CH3 5474 H ph H H H H H 5475 iPr CD3 H H H H H 5476 iPr CH3 H H H H H 5477 iPr H CD3 H H H H 5478 iPr H CH3 H H H H 5479 iPr H H CD3 H H H 5480 iPr H H CH3 H H H 5481 iPr H H H CD3 H H 5482 iPr H H H CH3 H H 5483 iPr H H H H CD3 H 5484 iPr H H H H CH3 H 5485 iPr H H H H H CD3 5486 iPr H H H H H CH3 5487 iPr H H H H H H LA5488 to LA5700 based on structure:

LA # R11 R12 R13 R31 R32 R33 5488 CD3 CD3 H H H H 5489 CD3 CH3 H H H H 5490 CD3 H 2,6DIP H H H 5491 CD3 H 2,6DMB H H H 5492 CD3 H CD3 H H H 5493 CD3 H CH3 H H H 5494 CD3 H H 2,6DIP H H 5495 CD3 H H 2,6DMB H H 5496 CD3 H H CD3 H H 5497 CD3 H H CH3 H H 5498 CD3 H H H 2,6DIP H 5499 CD3 H H H 2,6DMB H 5500 CD3 H H H CD3 H 5501 CD3 H H H CH3 H 5502 CD3 H H H H 2,6DIP 5503 CD3 H H H H 2,6DMB 5504 CD3 H H H H CD3 5505 CD3 H H H H CH3 5506 CD3 H H H H H 5507 CD3 H H H H iPr 5508 CD3 H H H iPr H 5509 CD3 H H iPr H H 5510 CD3 H iPr H H H 5511 CD3 iPr H H H H 5512 CH3 CD3 H H H H 5513 CH3 CH3 H H H H 5514 CH3 H 2,6DIP H H H 5515 CH3 H 2,6DMB H H H 5516 CH3 H CD3 H H H 5517 CH3 H CH3 H H H 5518 CH3 H H 2,6DIP H H 5519 CH3 H H 2,6DMB H H 5520 CH3 H H CD3 H H 5521 CH3 H H CH3 H H 5522 CH3 H H H 2,6DIP H 5523 CH3 H H H 2,6DMB H 5524 CH3 H H H CD3 H 5525 CH3 H H H CH3 H 5526 CH3 H H H H 2,6DIP 5527 CH3 H H H H 2,6DMB 5528 CH3 H H H H CD3 5529 CH3 H H H H CH3 5530 CH3 H H H H H 5531 CH3 H H H H iPr 5532 CH3 H H H iPr H 5533 CH3 H H iPr H H 5534 CH3 H iPr H H H 5535 CH3 iPr H H H H 5536 H 2,6DIP H CD3 H H 5537 H 2,6DIP H CH3 H H 5538 H 2,6DIP H H CD3 H 5539 H 2,6DIP H H CH3 H 5540 H 2,6DIP H H H CD3 5541 H 2,6DIP H H H CH3 5542 H 2,6DIP H H H H 5543 H 2,6DMB H CD3 H H 5544 H 2,6DMB H CH3 H H 5545 H 2,6DMB H H CD3 H 5546 H 2,6DMB H H CH3 H 5547 H 2,6DMB H H H CD3 5548 H 2,6DMB H H H CH3 5549 H 2,6DMB H H H H 5550 H CD3 CD3 H H H 5551 H CD3 CH3 H H H 5552 H CD3 H 2,6DIP H H 5553 H CD3 H 2,6DMB H H 5554 H CD3 H CD3 H H 5555 H CD3 H CH3 H H 5556 H CD3 H H 2,6DIP H 5557 H CD3 H H 2,6DMB H 5558 H CD3 H H CD3 H 5559 H CD3 H H CH3 H 5560 H CD3 H H H 2,6DIP 5561 H CD3 H H H 2,6DMB 5562 H CD3 H H H CD3 5563 H CD3 H H H CH3 5564 H CD3 H H H H 5565 H CD3 H H H iPr 5566 H CD3 H H iPr H 5567 H CD3 H iPr H H 5568 H CD3 iPr H H H 5569 H CH3 CD3 H H H 5570 H CH3 CH3 H H H 5571 H CH3 H 2,6DIP H H 5572 H CH3 H 2,6DMB H H 5573 H CH3 H CD3 H H 5574 H CH3 H CH3 H H 5575 H CH3 H H 2,6DIP H 5576 H CH3 H H 2,6DMB H 5577 H CH3 H H CD3 H 5578 H CH3 H H CH3 H 5579 H CH3 H H H 2,6DIP 5580 H CH3 H H H 2,6DMB 5581 H CH3 H H H CD3 5582 H CH3 H H H CH3 5583 H CH3 H H H H 5584 H CH3 H H H iPr 5585 H CH3 H H iPr H 5586 H CH3 H iPr H H 5587 H CH3 iPr H H H 5588 H H 2,6DIP H CD3 H 5589 H H 2,6DIP H CH3 H 5590 H H 2,6DIP H H CD3 5591 H H 2,6DIP H H CH3 5592 H H 2,6DIP H H H 5593 H H 2,6DMB H CD3 H 5594 H H 2,6DMB H CH3 H 5595 H H 2,6DMB H H CD3 5596 H H 2,6DMB H H CH3 5597 H H 2,6DMB H H H 5598 H H CD3 CD3 H H 5599 H H CD3 CH3 H H 5600 H H CD3 H 2,6DIP H 5601 H H CD3 H 2,6DMB H 5602 H H CD3 H CD3 H 5603 H H CD3 H CH3 H 5604 H H CD3 H H 2,6DIP 5605 H H CD3 H H 2,6DMB 5606 H H CD3 H H CD3 5607 H H CD3 H H CH3 5608 H H CD3 H H H 5609 H H CD3 H H iPr 5610 H H CD3 H iPr H 5611 H H CD3 iPr H H 5612 H H CH3 CD3 H H 5613 H H CH3 CH3 H H 5614 H H CH3 H 2,6DIP H 5615 H H CH3 H 2,6DMB H 5616 H H CH3 H CD3 H 5617 H H CH3 H CH3 H 5618 H H CH3 H H 2,6DIP 5619 H H CH3 H H 2,6DMB 5620 H H CH3 H H CD3 5621 H H CH3 H H CH3 5622 H H CH3 H H H 5623 H H CH3 H H iPr 5624 H H CH3 H iPr H 5625 H H CH3 iPr H H 5626 H H H 2,6DIP H CD3 5627 H H H 2,6DIP H CH3 5628 H H H 2,6DIP H H 5629 H H H 2,6DMB H CD3 5630 H H H 2,6DMB H CH3 5631 H H H 2,6DMB H H 5632 H H H CD3 CD3 H 5633 H H H CD3 CH3 H 5634 H H H CD3 H 2,6DIP 5635 H H H CD3 H 2,6DMB 5636 H H H CD3 H CD3 5637 H H H CD3 H CH3 5638 H H H CD3 H H 5639 H H H CD3 H iPr 5640 H H H CD3 iPr H 5641 H H H CH3 CD3 H 5642 H H H CH3 CH3 H 5643 H H H CH3 H 2,6DIP 5644 H H H CH3 H 2,6DMB 5645 H H H CH3 H CD3 5646 H H H CH3 H CH3 5647 H H H CH3 H H 5648 H H H CH3 H iPr 5649 H H H CH3 iPr H 5650 H H H H 2,6DIP H 5651 H H H H 2,6DMB H 5652 H H H H CD3 CD3 5653 H H H H CD3 CH3 5654 H H H H CD3 H 5655 H H H H CD3 iPr 5656 H H H H CH3 CD3 5657 H H H H CH3 CH3 5658 H H H H CH3 H 5659 H H H H CH3 iPr 5660 H H H H H 2,6DIP 5661 H H H H H 2,6DMB 5662 H H H H H CD3 5663 H H H H H CH3 5664 H H H H H H 5665 H H H H H iPr 5666 H H H H iPr CD3 5667 H H H H iPr CH3 5668 H H H H iPr H 5669 H H H iPr CD3 H 5670 H H H iPr CH3 H 5671 H H H iPr H CD3 5672 H H H iPr H CH3 5673 H H H iPr H H 5674 H H iPr CD3 H H 5675 H H iPr CH3 H H 5676 H H iPr H CD3 H 5677 H H iPr H CH3 H 5678 H H iPr H H CD3 5679 H H iPr H H CH3 5680 H H iPr H H H 5681 H iPr CD3 H H H 5682 H iPr CH3 H H H 5683 H iPr H CD3 H H 5684 H iPr H CH3 H H 5685 H iPr H H CD3 H 5686 H iPr H H CH3 H 5687 H iPr H H H CD3 5688 H iPr H H H CH3 5689 H iPr H H H H 5690 iPr CD3 H H H H 5691 iPr CH3 H H H H 5692 iPr H CD3 H H H 5693 iPr H CH3 H H H 5694 iPr H H CD3 H H 5695 iPr H H CH3 H H 5696 iPr H H H CD3 H 5697 iPr H H H CH3 H 5698 iPr H H H H CD3 5699 iPr H H H H CH3 5700 iPr H H H H H LA5701 to LA5921 based on structure:

LA # R11 R12 R13 R31 R32 R34 5701 CD3 CD3 H H H H 5702 CD3 CH3 H H H H 5703 CD3 H 2,6DIP H H H 5704 CD3 H 2,6DMB H H H 5705 CD3 H CD3 H H H 5706 CD3 H CH3 H H H 5707 CD3 H H 2,6DIP H H 5708 CD3 H H 2,6DMB H H 5709 CD3 H H CD3 H H 5710 CD3 H H CH3 H H 5711 CD3 H H H 2,6DIP H 5712 CD3 H H H 2,6DMB H 5713 CD3 H H H CD3 H 5714 CD3 H H H CH3 H 5715 CD3 H H H H 2,6DIP 5716 CD3 H H H H 2,6DMB 5717 CD3 H H H H CD3 5718 CD3 H H H H CH3 5719 CD3 H H H H H 5720 CD3 H H H H iPr 5721 CD3 H H H iPr H 5722 CD3 H H iPr H H 5723 CD3 H iPr H H H 5724 CD3 iPr H H H H 5725 CH3 CD3 H H H H 5726 CH3 CH3 H H H H 5727 CH3 H 2,6DIP H H H 5728 CH3 H 2,6DMB H H H 5729 CH3 H CD3 H H H 5730 CH3 H CH3 H H H 5731 CH3 H H 2,6DIP H H 5732 CH3 H H 2,6DMB H H 5733 CH3 H H CD3 H H 5734 CH3 H H CH3 H H 5735 CH3 H H H 2,6DIP H 5736 CH3 H H H 2,6DMB H 5737 CH3 H H H CD3 H 5738 CH3 H H H CH3 H 5739 CH3 H H H H 2,6DIP 5740 CH3 H H H H 2,6DMB 5741 CH3 H H H H CD3 5742 CH3 H H H H CH3 5743 CH3 H H H H H 5744 CH3 H H H H iPr 5745 CH3 H H H iPr H 5746 CH3 H H iPr H H 5747 CH3 H iPr H H H 5748 CH3 iPr H H H H 5749 H 2,6DIP H CD3 H H 5750 H 2,6DIP H CH3 H H 5751 H 2,6DIP H H CD3 H 5752 H 2,6DIP H H CH3 H 5753 H 2,6DIP H H H CD3 5754 H 2,6DIP H H H CH3 5755 H 2,6DIP H H H H 5756 H 2,6DMB H CD3 H H 5757 H 2,6DMB H CH3 H H 5758 H 2,6DMB H H CD3 H 5759 H 2,6DMB H H CH3 H 5760 H 2,6DMB H H H CD3 5761 H 2,6DMB H H H CH3 5762 H 2,6DMB H H H H 5763 H CD3 CD3 H H H 5764 H CD3 CH3 H H H 5765 H CD3 H 2,6DIP H H 5766 H CD3 H 2,6DMB H H 5767 H CD3 H CD3 H H 5768 H CD3 H CH3 H H 5769 H CD3 H H 2,6DIP H 5770 H CD3 H H 2,6DMB H 5771 H CD3 H H CD3 H 5772 H CD3 H H CH3 H 5773 H CD3 H H H 2,6DIP 5774 H CD3 H H H 2,6DMB 5775 H CD3 H H H CD3 5776 H CD3 H H H CH3 5777 H CD3 H H H H 5778 H CD3 H H H iPr 5779 H CD3 H H iPr H 5780 H CD3 H iPr H H 5781 H CD3 iPr H H H 5782 H CH3 CD3 H H H 5783 H CH3 CH3 H H H 5784 H CH3 H 2,6DIP H H 5785 H CH3 H 2,6DMB H H 5786 H CH3 H CD3 H H 5787 H CH3 H CH3 H H 5788 H CH3 H H 2,6DIP H 5789 H CH3 H H 2,6DMB H 5790 H CH3 H H CD3 H 5791 H CH3 H H CH3 H 5792 H CH3 H H H 2,6DIP 5793 H CH3 H H H 2,6DMB 5794 H CH3 H H H CD3 5795 H CH3 H H H CH3 5796 H CH3 H H H H 5797 H CH3 H H H iPr 5798 H CH3 H H iPr H 5799 H CH3 H iPr H H 5800 H CH3 iPr H H H 5801 H H 2,6DIP H CD3 H 5802 H H 2,6DIP H CH3 H 5803 H H 2,6DIP H H CD3 5804 H H 2,6DIP H H CH3 5805 H H 2,6DIP H H H 5806 H H 2,6DMB H CD3 H 5807 H H 2,6DMB H CH3 H 5808 H H 2,6DMB H H CD3 5809 H H 2,6DMB H H CH3 5810 H H 2,6DMB H H H 5811 H H CD3 CD3 H H 5812 H H CD3 CH3 H H 5813 H H CD3 H 2,6DIP H 5814 H H CD3 H 2,6DMB H 5815 H H CD3 H CD3 H 5816 H H CD3 H CH3 H 5817 H H CD3 H H 2,6DIP 5818 H H CD3 H H 2,6DMB 5819 H H CD3 H H CD3 5820 H H CD3 H H CH3 5821 H H CD3 H H H 5822 H H CD3 H H iPr 5823 H H CD3 H iPr H 5824 H H CD3 iPr H H 5825 H H CH3 CD3 H H 5826 H H CH3 CH3 H H 5827 H H CH3 H 2,6DIP H 5828 H H CH3 H 2,6DMB H 5829 H H CH3 H CD3 H 5830 H H CH3 H CH3 H 5831 H H CH3 H H 2,6DIP 5832 H H CH3 H H 2,6DMB 5833 H H CH3 H H CD3 5834 H H CH3 H H CH3 5835 H H CH3 H H H 5836 H H CH3 H H iPr 5837 H H CH3 H iPr H 5838 H H CH3 iPr H H 5839 H H H 2,6DIP H CD3 5840 H H H 2,6DIP H CH3 5841 H H H 2,6DIP H H 5842 H H H 2,6DMB H CD3 5843 H H H 2,6DMB H CH3 5844 H H H 2,6DMB H H 5845 H H H CD3 CD3 H 5846 H H H CD3 CH3 H 5847 H H H CD3 H 2,6DIP 5848 H H H CD3 H 2,6DMB 5849 H H H CD3 H CD3 5850 H H H CD3 H CH3 5851 H H H CD3 H H 5852 H H H CD3 H iPr 5853 H H H CD3 iPr H 5854 H H H CH3 CD3 H 5855 H H H CH3 CH3 H 5856 H H H CH3 H 2,6DIP 5857 H H H CH3 H 2,6DMB 5858 H H H CH3 H CD3 5859 H H H CH3 H CH3 5860 H H H CH3 H H 5861 H H H CH3 H iPr 5862 H H H CH3 iPr H 5863 H H H H 2,6DIP CD3 5864 H H H H 2,6DIP CH3 5865 H H H H 2,6DIP H 5866 H H H H 2,6DMB CD3 5867 H H H H 2,6DMB CH3 5868 H H H H 2,6DMB H 5869 H H H H CD3 2,6DIP 5870 H H H H CD3 2,6DMB 5871 H H H H CD3 CD3 5872 H H H H CD3 CH3 5873 H H H H CD3 H 5874 H H H H CD3 iPr 5875 H H H H CH3 2,6DIP 5876 H H H H CH3 2,6DMB 5877 H H H H CH3 CD3 5878 H H H H CH3 CH3 5879 H H H H CH3 H 5880 H H H H CH3 iPr 5881 H H H H H 2,6DIP 5882 H H H H H 2,6DMB 5883 H H H H H CD3 5884 H H H H H CH3 5885 H H H H H H 5886 H H H H H iPr 5887 H H H H iPr CD3 5888 H H H H iPr CH3 5889 H H H H iPr H 5890 H H H iPr CD3 H 5891 H H H iPr CH3 H 5892 H H H iPr H CD3 5893 H H H iPr H CH3 5894 H H H iPr H H 5895 H H iPr CD3 H H 5896 H H iPr CH3 H H 5897 H H iPr H CD3 H 5898 H H iPr H CH3 H 5899 H H iPr H H CD3 5900 H H iPr H H CH3 5901 H H iPr H H H 5902 H iPr CD3 H H H 5903 H iPr CH3 H H H 5904 H iPr H CD3 H H 5905 H iPr H CH3 H H 5906 H iPr H H CD3 H 5907 H iPr H H CH3 H 5908 H iPr H H H CD3 5909 H iPr H H H CH3 5910 H iPr H H H H 5911 iPr CD3 H H H H 5912 iPr CH3 H H H H 5913 iPr H CD3 H H H 5914 iPr H CH3 H H H 5915 iPr H H CD3 H H 5916 iPr H H CH3 H H 5917 iPr H H H CD3 H 5918 iPr H H H CH3 H 5919 iPr H H H H CD3 5920 iPr H H H H CH3 5921 iPr H H H H H LA5922 to LA6142 based on structure:

LA # R11 R12 R13 R31 R33 R34 5922 CD3 CD3 H H H H 5923 CD3 CH3 H H H H 5924 CD3 H 2,6DIP H H H 5925 CD3 H 2,6DMB H H H 5926 CD3 H CD3 H H H 5927 CD3 H CH3 H H H 5928 CD3 H H 2,6DIP H H 5929 CD3 H H 2,6DMB H H 5930 CD3 H H CD3 H H 5931 CD3 H H CH3 H H 5932 CD3 H H H 2,6DIP H 5933 CD3 H H H 2,6DMB H 5934 CD3 H H H CD3 H 5935 CD3 H H H CH3 H 5936 CD3 H H H H 2,6DIP 5937 CD3 H H H H 2,6DMB 5938 CD3 H H H H CD3 5939 CD3 H H H H CH3 5940 CD3 H H H H H 5941 CD3 H H H H iPr 5942 CD3 H H H iPr H 5943 CD3 H H iPr H H 5944 CD3 H iPr H H H 5945 CD3 iPr H H H H 5946 CH3 CD3 H H H H 5947 CH3 CH3 H H H H 5948 CH3 H 2,6DIP H H H 5949 CH3 H 2,6DMB H H H 5950 CH3 H CD3 H H H 5951 CH3 H CH3 H H H 5952 CH3 H H 2,6DIP H H 5953 CH3 H H 2,6DMB H H 5954 CH3 H H CD3 H H 5955 CH3 H H CH3 H H 5956 CH3 H H H 2,6DIP H 5957 CH3 H H H 2,6DMB H 5958 CH3 H H H CD3 H 5959 CH3 H H H CH3 H 5960 CH3 H H H H 2,6DIP 5961 CH3 H H H H 2,6DMB 5962 CH3 H H H H CD3 5963 CH3 H H H H CH3 5964 CH3 H H H H H 5965 CH3 H H H H iPr 5966 CH3 H H H iPr H 5967 CH3 H H iPr H H 5968 CH3 H iPr H H H 5969 CH3 iPr H H H H 5970 H 2,6DIP H CD3 H H 5971 H 2,6DIP H CH3 H H 5972 H 2,6DIP H H CD3 H 5973 H 2,6DIP H H CH3 H 5974 H 2,6DIP H H H CD3 5975 H 2,6DIP H H H CH3 5976 H 2,6DIP H H H H 5977 H 2,6DMB H CD3 H H 5978 H 2,6DMB H CH3 H H 5979 H 2,6DMB H H CD3 H 5980 H 2,6DMB H H CH3 H 5981 H 2,6DMB H H H CD3 5982 H 2,6DMB H H H CH3 5983 H 2,6DMB H H H H 5984 H CD3 CD3 H H H 5985 H CD3 CH3 H H H 5986 H CD3 H 2,6DIP H H 5987 H CD3 H 2,6DMB H H 5988 H CD3 H CD3 H H 5989 H CD3 H CH3 H H 5990 H CD3 H H 2,6DIP H 5991 H CD3 H H 2,6DMB H 5992 H CD3 H H CD3 H 5993 H CD3 H H CH3 H 5994 H CD3 H H H 2,6DIP 5995 H CD3 H H H 2,6DMB 5996 H CD3 H H H CD3 5997 H CD3 H H H CH3 5998 H CD3 H H H H 5999 H CD3 H H H iPr 6000 H CD3 H H iPr H 6001 H CD3 H iPr H H 6002 H CD3 iPr H H H 6003 H CH3 CD3 H H H 6004 H CH3 CH3 H H H 6005 H CH3 H 2,6DIP H H 6006 H CH3 H 2,6DMB H H 6007 H CH3 H CD3 H H 6008 H CH3 H CH3 H H 6009 H CH3 H H 2,6DIP H 6010 H CH3 H H 2,6DMB H 6011 H CH3 H H CD3 H 6012 H CH3 H H CH3 H 6013 H CH3 H H H 2,6DIP 6014 H CH3 H H H 2,6DMB 6015 H CH3 H H H CD3 6016 H CH3 H H H CH3 6017 H CH3 H H H H 6018 H CH3 H H H iPr 6019 H CH3 H H iPr H 6020 H CH3 H iPr H H 6021 H CH3 iPr H H H 6022 H H 2,6DIP H CD3 H 6023 H H 2,6DIP H CH3 H 6024 H H 2,6DIP H H CD3 6025 H H 2,6DIP H H CH3 6026 H H 2,6DIP H H H 6027 H H 2,6DMB H CD3 H 6028 H H 2,6DMB H CH3 H 6029 H H 2,6DMB H H CD3 6030 H H 2,6DMB H H CH3 6031 H H 2,6DMB H H H 6032 H H CD3 CD3 H H 6033 H H CD3 CH3 H H 6034 H H CD3 H 2,6DIP H 6035 H H CD3 H 2,6DMB H 6036 H H CD3 H CD3 H 6037 H H CD3 H CH3 H 6038 H H CD3 H H 2,6DIP 6039 H H CD3 H H 2,6DMB 6040 H H CD3 H H CD3 6041 H H CD3 H H CH3 6042 H H CD3 H H H 6043 H H CD3 H H iPr 6044 H H CD3 H iPr H 6045 H H CD3 iPr H H 6046 H H CH3 CD3 H H 6047 H H CH3 CH3 H H 6048 H H CH3 H 2,6DIP H 6049 H H CH3 H 2,6DMB H 6050 H H CH3 H CD3 H 6051 H H CH3 H CH3 H 6052 H H CH3 H H 2,6DIP 6053 H H CH3 H H 2,6DMB 6054 H H CH3 H H CD3 6055 H H CH3 H H CH3 6056 H H CH3 H H H 6057 H H CH3 H H iPr 6058 H H CH3 H iPr H 6059 H H CH3 iPr H H 6060 H H H 2,6DIP CD3 H 6061 H H H 2,6DIP CH3 H 6062 H H H 2,6DIP H CD3 6063 H H H 2,6DIP H CH3 6064 H H H 2,6DIP H H 6065 H H H 2,6DMB CD3 H 6066 H H H 2,6DMB CH3 H 6067 H H H 2,6DMB H CD3 6068 H H H 2,6DMB H CH3 6069 H H H 2,6DMB H H 6070 H H H CD3 2,6DIP H 6071 H H H CD3 2,6DMB H 6072 H H H CD3 CD3 H 6073 H H H CD3 CH3 H 6074 H H H CD3 H 2,6DIP 6075 H H H CD3 H 2,6DMB 6076 H H H CD3 H CD3 6077 H H H CD3 H CH3 6078 H H H CD3 H H 6079 H H H CD3 H iPr 6080 H H H CD3 iPr H 6081 H H H CH3 2,6DIP H 6082 H H H CH3 2,6DMB H 6083 H H H CH3 CD3 H 6084 H H H CH3 CH3 H 6085 H H H CH3 H 2,6DIP 6086 H H H CH3 H 2,6DMB 6087 H H H CH3 H CD3 6088 H H H CH3 H CH3 6089 H H H CH3 H H 6090 H H H CH3 H iPr 6091 H H H CH3 iPr H 6092 H H H H 2,6DIP H 6093 H H H H 2,6DMB H 6094 H H H H CD3 CD3 6095 H H H H CD3 CH3 6096 H H H H CD3 H 6097 H H H H CD3 iPr 6098 H H H H CH3 CD3 6099 H H H H CH3 CH3 6100 H H H H CH3 H 6101 H H H H CH3 iPr 6102 H H H H H 2,6DIP 6103 H H H H H 2,6DMB 6104 H H H H H CD3 6105 H H H H H CH3 6106 H H H H H H 6107 H H H H H iPr 6108 H H H H iPr CD3 6109 H H H H iPr CH3 6110 H H H H iPr H 6111 H H H iPr CD3 H 6112 H H H iPr CH3 H 6113 H H H iPr H CD3 6114 H H H iPr H CH3 6115 H H H iPr H H 6116 H H iPr CD3 H H 6117 H H iPr CH3 H H 6118 H H iPr H CD3 H 6119 H H iPr H CH3 H 6120 H H iPr H H CD3 6121 H H iPr H H CH3 6122 H H iPr H H H 6123 H iPr CD3 H H H 6124 H iPr CH3 H H H 6125 H iPr H CD3 H H 6126 H iPr H CH3 H H 6127 H iPr H H CD3 H 6128 H iPr H H CH3 H 6129 H iPr H H H CD3 6130 H iPr H H H CH3 6131 H iPr H H H H 6132 iPr CD3 H H H H 6133 iPr CH3 H H H H 6134 iPr H CD3 H H H 6135 iPr H CH3 H H H 6136 iPr H H CD3 H H 6137 iPr H H CH3 H H 6138 iPr H H H CD3 H 6139 iPr H H H CH3 H 6140 iPr H H H H CD3 6141 iPr H H H H CH3 6142 iPr H H H H H LA6143 to LA6363 based on structure:

LA # R11 R12 R13 R32 R33 R34 6143 CD3 C3 H H H H 6144 CD3 CH3 H H H H 6145 CD3 H 2,6DIP H H H 6146 CD3 H 2,6DMB H H H 6147 CD3 H CD3 H H H 6148 CD3 H CH3 H H H 6149 CD3 H H 2,6DIP H H 6150 CD3 H H 2,6DMB H H 6151 CD3 H H CD3 H H 6152 CD3 H H CH3 H H 6153 CD3 H H H 2,6DIP H 6154 CD3 H H H 2,6DMB H 6155 CD3 H H H CD3 H 6156 CD3 H H H CH3 H 6157 CD3 H H H H 2,6DIP 6158 CD3 H H H H 2,6DMB 6159 CD3 H H H H CD3 6160 CD3 H H H H CH3 6161 CD3 H H H H H 6162 CD3 H H H H iPr 6163 CD3 H H H iPr H 6164 CD3 H H iPr H H 6165 CD3 H iPr H H H 6166 CD3 iPr H H H H 6167 CH3 CD3 H H H H 6168 CH3 CH3 H H H H 6169 CH3 H 2,6DIP H H H 6170 CH3 H 2,6DMB H H H 6171 CH3 H CD3 H H H 6172 CH3 H CH3 H H H 6173 CH3 H H 2,6DIP H H 6174 CH3 H H 2,6DMB H H 6175 CH3 H H CD3 H H 6176 CH3 H H CH3 H H 6177 CH3 H H H 2,6DIP H 6178 CH3 H H H 2,6DMB H 6179 CH3 H H H CD3 H 6180 CH3 H H H CH3 H 6181 CH3 H H H H 2,6DIP 6182 CH3 H H H H 2,6DMB 6183 CH3 H H H H CD3 6184 CH3 H H H H CH3 6185 CH3 H H H H H 6186 CH3 H H H H iPr 6187 CH3 H H H iPr H 6188 CH3 H H iPr H H 6189 CH3 H iPr H H H 6190 CH3 iPr H H H H 6191 H 2,6DIP H CD3 H H 6192 H 2,6DIP H CH3 H H 6193 H 2,6DIP H H CD3 H 6194 H 2,6DIP H H CH3 H 6195 H 2,6DIP H H H CD3 6196 H 2,6DIP H H H CH3 6197 H 2,6DIP H H H H 6198 H 2,6DMB H CD3 H H 6199 H 2,6DMB H CH3 H H 6200 H 2,6DMB H H CD3 H 6201 H 2,6DMB H H CH3 H 6202 H 2,6DMB H H H CD3 6203 H 2,6DMB H H H CH3 6204 H 2,6DMB H H H H 6205 H CD3 CD3 H H H 6206 H CD3 CH3 H H H 6207 H CD3 H 2,6DIP H H 6208 H CD3 H 2,6DMB H H 6209 H CD3 H CD3 H H 6210 H CD3 H CH3 H H 6211 H CD3 H H 2,6DIP H 6212 H CD3 H H 2,6DMB H 6213 H CD3 H H CD3 H 6214 H CD3 H H CH3 H 6215 H CD3 H H H 2,6DIP 6216 H CD3 H H H 2,6DMB 6217 H CD3 H H H CD3 6218 H CD3 H H H CH3 6219 H CD3 H H H H 6220 H CD3 H H H iPr 6221 H CD3 H H iPr H 6222 H CD3 H iPr H H 6223 H CD3 iPr H H H 6224 H CH3 CD3 H H H 6225 H CH3 CH3 H H H 6226 H CH3 H 2,6DIP H H 6227 H CH3 H 2,6DMB H H 6228 H CH3 H CD3 H H 6229 H CH3 H CH3 H H 6230 H CH3 H H 2,6DIP H 6231 H CH3 H H 2,6DMB H 6232 H CH3 H H CD3 H 6233 H CH3 H H CH3 H 6234 H CH3 H H H 2,6DIP 6235 H CH3 H H H 2,6DMB 6236 H CH3 H H H CD3 6237 H CH3 H H H CH3 6238 H CH3 H H H H 6239 H CH3 H H H iPr 6240 H CH3 H H iPr H 6241 H CH3 H iPr H H 6242 H CH3 iPr H H H 6243 H H 2,6DIP CD3 H H 6244 H H 2,6DIP CH3 H H 6245 H H 2,6DIP H CD3 H 6246 H H 2,6DIP H CH3 H 6247 H H 2,6DIP H H CD3 6248 H H 2,6DIP H H CH3 6249 H H 2,6DIP H H H 6250 H H 2,6DMB CD3 H H 6251 H H 2,6DMB CH3 H H 6252 H H 2,6DMB H CD3 H 6253 H H 2,6DMB H CH3 H 6254 H H 2,6DMB H H CD3 6255 H H 2,6DMB H H CH3 6256 H H 2,6DMB H H H 6257 H H CD3 2,6DIP H H 6258 H H CD3 2,6DMB H H 6259 H H CD3 CD3 H H 6260 H H CD3 CH3 H H 6261 H H CD3 H 2,6DIP H 6262 H H CD3 H 2,6DMB H 6263 H H CD3 H CD3 H 6264 H H CD3 H CH3 H 6265 H H CD3 H H 2,6DIP 6266 H H CD3 H H 2,6DMB 6267 H H CD3 H H CD3 6268 H H CD3 H H CH3 6269 H H CD3 H H H 6270 H H CD3 H H iPr 6271 H H CD3 H iPr H 6272 H H CD3 iPr H H 6273 H H CH3 2,6DIP H H 6274 H H CH3 2,6DMB H H 6275 H H CH3 CD3 H H 6276 H H CH3 CH3 H H 6277 H H CH3 H 2,6DIP H 6278 H H CH3 H 2,6DMB H 6279 H H CH3 H CD3 H 6280 H H CH3 H CH3 H 6281 H H CH3 H H 2,6DIP 6282 H H CH3 H H 2,6DMB 6283 H H CH3 H H CD3 6284 H H CH3 H H CH3 6285 H H CH3 H H H 6286 H H CH3 H H iPr 6287 H H CH3 H iPr H 6288 H H CH3 iPr H H 6289 H H H 2,6DIP H CD3 6290 H H H 2,6DIP H CH3 6291 H H H 2,6DIP H H 6292 H H H 2,6DMB H CD3 6293 H H H 2,6DMB H CH3 6294 H H H 2,6DMB H H 6295 H H H CD3 CD3 H 6296 H H H CD3 CH3 H 6297 H H H CD3 H 2,6DIP 6298 H H H CD3 H 2,6DMB 6299 H H H CD3 H CD3 6300 H H H CD3 H CH3 6301 H H H CD3 H H 6302 H H H CD3 H iPr 6303 H H H CD3 iPr H 6304 H H H CH3 CD3 H 6305 H H H CH3 CH3 H 6306 H H H CH3 H 2,6DIP 6307 H H H CH3 H 2,6DMB 6308 H H H CH3 H CD3 6309 H H H CH3 H CH3 6310 H H H CH3 H H 6311 H H H CH3 H iPr 6312 H H H CH3 iPr H 6313 H H H H 2,6DIP H 6314 H H H H 2,6DMB H 6315 H H H H CD3 CD3 6316 H H H H CD3 CH3 6317 H H H H CD3 H 6318 H H H H CD3 iPr 6319 H H H H CH3 CD3 6320 H H H H CH3 CH3 6321 H H H H CH3 H 6322 H H H H CH3 iPr 6323 H H H H H 2,6DIP 6324 H H H H H 2,6DMB 6325 H H H H H CD3 6326 H H H H H CH3 6327 H H H H H H 6328 H H H H H iPr 6329 H H H H iPr CD3 6330 H H H H iPr CH3 6331 H H H H iPr H 6332 H H H iPr CD3 H 6333 H H H iPr CH3 H 6334 H H H iPr H CD3 6335 H H H iPr H CH3 6336 H H H iPr H H 6337 H H iPr CD3 H H 6338 H H iPr CH3 H H 6339 H H iPr H CD3 H 6340 H H iPr H CH3 H 6341 H H iPr H H CD3 6342 H H iPr H H CH3 6343 H H iPr H H H 6344 H iPr CD3 H H H 6345 H iPr CH3 H H H 6346 H iPr H CD3 H H 6347 H iPr H CH3 H H 6348 H iPr H H CD3 H 6349 H iPr H H CH3 H 6350 H iPr H H H CD3 6351 H iPr H H H CH3 6352 H iPr H H H H 6353 iPr CD3 H H H H 6354 iPr CH3 H H H H 6355 iPr H CD3 H H H 6356 iPr H CH3 H H H 6357 iPr H H CD3 H H 6358 iPr H H CH3 H H 6359 iPr H H H CD3 H 6360 iPr H H H CH3 H 6361 iPr H H H H CD3 6362 iPr H H H H CH3 6363 iPr H H H H H

wherein 2,6DIP is 2,6 diisopropyl benzene, 2,6DMB is 2,6 dimethyl benzene, and i-Pr is isopropyl.

In one embodiment, the compound has a formula of M(L_(A))_(n)(L_(B))_(m-n);

-   -   wherein M is Ir or Pt;     -   L_(B) is a bidentate ligand; and     -   wherein when M is Ir, m is 3, and n is 1, 2, or 3; when M is Pt,         m is 2, and n is 1, or 2.

In one embodiment, the compound has a formula of Ir(L_(A))₃. In another embodiment, the compound has a formula of Ir(L_(A))(L_(B))₂; and wherein L_(B) is different from L_(A). In another embodiment, the compound has a formula of Ir(L_(A))₂(L_(B)); and wherein L_(B) is different from L_(A). In another embodiment, the compound has a formula of Pt(L_(A))(L_(B)); and wherein L_(A) and L_(B) can be same or different.

In one embodiment, L_(A) and L_(B) are connected to form a tetradentate ligand. In another embodiment, L_(A) and L_(B) are connected at two places to form a macrocyclic tetradentate ligand.

In one embodiment, L_(B) is selected from the group consisting of:

wherein each X¹ to X¹³ are independently selected from the group consisting of carbon and nitrogen;

wherein X is selected from the group consisting of BR′, NR′, PR′, O, S, Se, C═O, S═O, SO₂, CR′R″, SiR′R″, and GeR′R″;

wherein R′ and R″ are optionally fused or joined to form a ring;

wherein each R_(a), R_(b), R_(c), and R_(d) may represent from mono substitution to the possible maximum number of substitution, or no substitution;

wherein R′, R″, R_(a), R_(b), R_(c), and R_(d) are each independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; and

wherein any two adjacent substituents of R_(a), R_(b), R_(c), and R_(d) are optionally fused or joined to form a ring or form a multidentate ligand.

In one embodiment, L_(B) is selected from the group consisting of:

In one embodiment, the compound is Compound Ax having the formula Ir(L_(Ai))₃; and wherein x=i; i is an integer from 1 to 6363.

In one embodiment, the compound is the Compound By having the formula Ir(L_(Ai))(L_(j))₂ or Compound Cz having the formula Ir(L_(Ai))₂(L_(j));

wherein y=39i+j−39; i is an integer from 1 to 6363, and j is an integer from 1 to 39;

wherein z=39i+j−39; i is an integer from 1 to 6363, and j is an integer from 1 to 39; and

wherein L₁ to L₃₉ have the following structure:

In some embodiments, the compound can be an emissive dopant. In some embodiments, the compound can produce emissions via phosphorescence, fluorescence, thermally activated delayed fluorescence, i.e., TADF (also referred to as E-type delayed fluorescence), triplet-triplet annihilation, or combinations of these processes.

According to another aspect of the present disclosure, an OLED is also provided. The OLED includes an anode, a cathode, and an organic layer disposed between the anode and the cathode. The organic layer may include a host and a phosphorescent dopant. The organic layer can include a compound according to Formula I, and its variations as described herein.

The OLED can be incorporated into one or more of a consumer product, an electronic component module, and a lighting panel. The organic layer can be an emissive layer and the compound can be an emissive dopant in some embodiments, while the compound can be a non-emissive dopant in other embodiments.

The organic layer can also include a host. In some embodiments, two or more hosts are preferred. In some embodiments, the hosts used maybe a) bipolar, b) electron transporting, c) hole transporting or d) wide band gap materials that play little role in charge transport. In some embodiments, the host can include a metal complex. The host can be a triphenylene containing benzo-fused thiophene or benzo-fused furan. Any substituent in the host can be an unfused substituent independently selected from the group consisting of C_(n)H_(2n+1), OC_(n)H_(2n+1), OAr₁, N(C_(n)H_(2n+1))₂, N(Ar₁)(Ar₂), CH═CH—C_(n)H_(2n+1), C≡C—C_(n)H_(2n+1), Ar₁, Ar₁-Ar₂, and C_(n)H_(2n)—Ar₁, or the host has no substitution. In the preceding substituents n can range from 1 to 10; and Ar₁ and Ar₂ can be independently selected from the group consisting of benzene, biphenyl, naphthalene, triphenylene, carbazole, and heteroaromatic analogs thereof. The host can be an inorganic compound. For example a Zn containing inorganic material e.g. ZnS.

The host can be a compound comprising at least one chemical group selected from the group consisting of triphenylene, carbazole, dibenzothiophene, dibenzofuran, dibenzoselenophene, azatriphenylene, azacarbazole, aza-dibenzothiophene, aza-dibenzofuran, and aza-dibenzoselenophene. The host can include a metal complex. The host can be, but is not limited to, a specific compound selected from the group consisting of:

and combinations thereof. Additional information on possible hosts is provided below.

In yet another aspect of the present disclosure, a formulation that comprises a compound comprising a ligand L_(A) selected from the group consisting of Formula I and Formula II. The formulation can include one or more components selected from the group consisting of a solvent, a host, a hole injection material, hole transport material, and an electron transport layer material, disclosed herein.

Combination with Other Materials

The materials described herein as useful for a particular layer in an organic light emitting device may be used in combination with a wide variety of other materials present in the device. For example, emissive dopants disclosed herein may be used in conjunction with a wide variety of hosts, transport layers, blocking layers, injection layers, electrodes and other layers that may be present. The materials described or referred to below are non-limiting examples of materials that may be useful in combination with the compounds disclosed herein, and one of skill in the art can readily consult the literature to identify other materials that may be useful in combination.

Conductivity Dopants:

A charge transport layer can be doped with conductivity dopants to substantially alter its density of charge carriers, which will in turn alter its conductivity. The conductivity is increased by generating charge carriers in the matrix material, and depending on the type of dopant, a change in the Fermi level of the semiconductor may also be achieved. Hole-transporting layer can be doped by p-type conductivity dopants and n-type conductivity dopants are used in the electron-transporting layer.

Non-limiting examples of the conductivity dopants that may be used in an OLED in combination with materials disclosed herein are exemplified below together with references that disclose those materials: EP01617493, EP01968131, EP2020694, EP2684932, US20050139810, US20070160905, US20090167167, US2010288362, WO06081780, WO2009003455, WO2009008277, WO2009011327, WO2014009310, US2007252140, US2015060804 and US2012146012.

HIL/HTL:

A hole injecting/transporting material to be used in the present invention is not particularly limited, and any compound may be used as long as the compound is typically used as a hole injecting/transporting material. Examples of the material include, but are not limited to: a phthalocyanine or porphyrin derivative; an aromatic amine derivative; an indolocarbazole derivative; a polymer containing fluorohydrocarbon; a polymer with conductivity dopants; a conducting polymer, such as PEDOT/PSS; a self-assembly monomer derived from compounds such as phosphonic acid and silane derivatives; a metal oxide derivative, such as MoO_(x); a p-type semiconducting organic compound, such as 1,4,5,8,9,12-Hexaazatriphenylenehexacarbonitrile; a metal complex, and a cross-linkable compounds.

Examples of aromatic amine derivatives used in HIL or HTL include, but not limit to the following general structures:

Each of Ar¹ to Ar⁹ is selected from the group consisting of aromatic hydrocarbon cyclic compounds such as benzene, biphenyl, triphenyl, triphenylene, naphthalene, anthracene, phenalene, phenanthrene, fluorene, pyrene, chrysene, perylene, and azulene; the group consisting of aromatic heterocyclic compounds such as dibenzothiophene, dibenzofuran, dibenzoselenophene, furan, thiophene, benzofuran, benzothiophene, benzoselenophene, carbazole, indolocarbazole, pyridylindole, pyrrolodipyridine, pyrazole, imidazole, triazole, oxazole, thiazole, oxadiazole, oxatriazole, dioxazole, thiadiazole, pyridine, pyridazine, pyrimidine, pyrazine, triazine, oxazine, oxathiazine, oxadiazine, indole, benzimidazole, indazole, indoxazine, benzoxazole, benzisoxazole, benzothiazole, quinoline, isoquinoline, cinnoline, quinazoline, quinoxaline, naphthyridine, phthalazine, pteridine, xanthene, acridine, phenazine, phenothiazine, phenoxazine, benzofuropyridine, furodipyridine, benzothienopyridine, thienodipyridine, benzoselenophenopyridine, and selenophenodipyridine; and the group consisting of 2 to 10 cyclic structural units which are groups of the same type or different types selected from the aromatic hydrocarbon cyclic group and the aromatic heterocyclic group and are bonded to each other directly or via at least one of oxygen atom, nitrogen atom, sulfur atom, silicon atom, phosphorus atom, boron atom, chain structural unit and the aliphatic cyclic group. Each Ar may be unsubstituted or may be substituted by a substituent selected from the group consisting of deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof.

In one aspect, Ar¹ to Ar⁹ is independently selected from the group consisting of:

wherein k is an integer from 1 to 20; X¹⁰¹ to X¹⁰⁸ is C (including CH) or N; Z¹⁰¹ is NAr¹, O, or S; Ar¹ has the same group defined above.

Examples of metal complexes used in HIL or HTL include, but are not limited to the following general formula:

wherein Met is a metal, which can have an atomic weight greater than 40; (Y¹⁰¹-Y¹⁰²) is a bidentate ligand, Y¹⁰¹ and Y¹⁰² are independently selected from C, N, O, P, and S; L¹⁰¹ is an ancillary ligand; k′ is an integer value from 1 to the maximum number of ligands that may be attached to the metal; and k′+k″ is the maximum number of ligands that may be attached to the metal.

In one aspect, (Y₁₀₁-Y¹⁰²) is a 2-phenylpyridine derivative. In another aspect, (Y¹⁰¹-Y¹⁰²) is a carbene ligand. In another aspect, Met is selected from Ir, Pt, Os, and Zn. In a further aspect, the metal complex has a smallest oxidation potential in solution vs. Fc⁺/Fc couple less than about 0.6 V.

Non-limiting examples of the HIL and HTL materials that may be used in an OLED in combination with materials disclosed herein are exemplified below together with references that disclose those materials: CN102702075, DE102012005215, EP01624500, EP01698613, EP01806334, EP01930964, EP01972613, EP01997799, EP02011790, EP02055700, EP02055701, EP1725079, EP2085382, EP2660300, EP650955, JP07-073529, JP2005112765, JP2007091719, JP2008021687, JP2014-009196, KR20110088898, KR20130077473, TW201139402, U.S. Ser. No. 06/517,957, US20020158242, US20030162053, US20050123751, US20060182993, US20060240279, US20070145888, US20070181874, US20070278938, US20080014464, US20080091025, US20080106190, US20080124572, US20080145707, US20080220265, US20080233434, US20080303417, US2008107919, US20090115320, US20090167161, US2009066235, US2011007385, US20110163302, US2011240968, US2011278551, US2012205642, US2013241401, US20140117329, US2014183517, U.S. Pat. Nos. 5,061,569, 5,639,914, WO05075451, WO07125714, WO08023550, WO08023759, WO2009145016, WO2010061824, WO2011075644, WO2012177006, WO2013018530, WO2013039073, WO2013087142, WO2013118812, WO2013120577, WO2013157367, WO2013175747, WO2014002873, WO2014015935, WO2014015937, WO2014030872, WO2014030921, WO2014034791, WO2014104514, WO2014157018.

EBL:

An electron blocking layer (EBL) may be used to reduce the number of electrons and/or excitons that leave the emissive layer. The presence of such a blocking layer in a device may result in substantially higher efficiencies, and or longer lifetime, as compared to a similar device lacking a blocking layer. Also, a blocking layer may be used to confine emission to a desired region of an OLED. In some embodiments, the EBL material has a higher LUMO (closer to the vacuum level) and/or higher triplet energy than the emitter closest to the EBL interface. In some embodiments, the EBL material has a higher LUMO (closer to the vacuum level) and or higher triplet energy than one or more of the hosts closest to the EBL interface. In one aspect, the compound used in EBL contains the same molecule or the same functional groups used as one of the hosts described below.

Host:

The light emitting layer of the organic EL device of the present invention preferably contains at least a metal complex as light emitting material, and may contain a host material using the metal complex as a dopant material. Examples of the host material are not particularly limited, and any metal complexes or organic compounds may be used as long as the triplet energy of the host is larger than that of the dopant. Any host material may be used with any dopant so long as the triplet criteria is satisfied.

Examples of metal complexes used as host are preferred to have the following general formula:

wherein Met is a metal; (Y¹⁰³-Y¹⁰⁴) is a bidentate ligand, Y¹⁰³ and Y¹⁰⁴ are independently selected from C, N, O, P, and S; L¹⁰¹ is an another ligand; k′ is an integer value from 1 to the maximum number of ligands that may be attached to the metal; and k′+k″ is the maximum number of ligands that may be attached to the metal.

In one aspect, the metal complexes are:

wherein (O—N) is a bidentate ligand, having metal coordinated to atoms O and N.

In another aspect, Met is selected from Ir and Pt. In a further aspect, (Y¹⁰³-Y¹⁰⁴) is a carbene ligand.

Examples of other organic compounds used as host are selected from the group consisting of aromatic hydrocarbon cyclic compounds such as benzene, biphenyl, triphenyl, triphenylene, tetraphenylene, naphthalene, anthracene, phenalene, phenanthrene, fluorene, pyrene, chrysene, perylene, and azulene; the group consisting of aromatic heterocyclic compounds such as dibenzothiophene, dibenzofuran, dibenzoselenophene, furan, thiophene, benzofuran, benzothiophene, benzoselenophene, carbazole, indolocarbazole, pyridylindole, pyrrolodipyridine, pyrazole, imidazole, triazole, oxazole, thiazole, oxadiazole, oxatriazole, dioxazole, thiadiazole, pyridine, pyridazine, pyrimidine, pyrazine, triazine, oxazine, oxathiazine, oxadiazine, indole, benzimidazole, indazole, indoxazine, benzoxazole, benzisoxazole, benzothiazole, quinoline, isoquinoline, cinnoline, quinazoline, quinoxaline, naphthyridine, phthalazine, pteridine, xanthene, acridine, phenazine, phenothiazine, phenoxazine, benzofuropyridine, furodipyridine, benzothienopyridine, thienodipyridine, benzoselenophenopyridine, and selenophenodipyridine; and the group consisting of 2 to 10 cyclic structural units which are groups of the same type or different types selected from the aromatic hydrocarbon cyclic group and the aromatic heterocyclic group and are bonded to each other directly or via at least one of oxygen atom, nitrogen atom, sulfur atom, silicon atom, phosphorus atom, boron atom, chain structural unit and the aliphatic cyclic group. Each option within each group may be unsubstituted or may be substituted by a substituent selected from the group consisting of deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof.

In one aspect, the host compound contains at least one of the following groups in the molecule:

wherein each of R¹⁰¹ to R¹⁰⁷ is independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof, and when it is aryl or heteroaryl, it has the similar definition as Ar's mentioned above. k is an integer from 0 to 20 or 1 to 20; k′″ is an integer from 0 to 20. X¹⁰¹ to X¹⁰⁸ is selected from C (including CH) or N. Z¹⁰¹ and Z¹⁰² is selected from NR¹⁰¹, O, or S.

Non-limiting examples of the host materials that may be used in an OLED in combination with materials disclosed herein are exemplified below together with references that disclose those materials: EP2034538, EP2034538A, EP2757608, JP2007254297, KR20100079458, KR20120088644, KR20120129733, KR20130115564, TW201329200, US20030175553, US20050238919, US20060280965, US20090017330, US20090030202, US20090167162, US20090302743, US20090309488, US20100012931, US20100084966, US20100187984, US2010187984, US2012075273, US2012126221, US2013009543, US2013105787, US2013175519, US2014001446, US20140183503, US20140225088, US2014034914, U.S. Pat. No. 7,154,114, WO2001039234, WO2004093207, WO2005014551, WO2005089025, WO2006072002, WO2006114966, WO2007063754, WO2008056746, WO2009003898, WO2009021126, WO2009063833, WO2009066778, WO2009066779, WO2009086028, WO2010056066, WO2010107244, WO2011081423, WO2011081431, WO2011086863, WO2012128298, WO2012133644, WO2012133649, WO2013024872, WO2013035275, WO2013081315, WO2013191404, WO2014142472,

Additional Emitters:

One or more additional emitter dopants may be used in conjunction with the compound of the present disclosure. Examples of the additional emitter dopants are not particularly limited, and any compounds may be used as long as the compounds are typically used as emitter materials. Examples of suitable emitter materials include, but are not limited to, compounds which can produce emissions via phosphorescence, fluorescence, thermally activated delayed fluorescence, i.e., TADF (also referred to as E-type delayed fluorescence), triplet-triplet annihilation, or combinations of these processes.

Non-limiting examples of the emitter materials that may be used in an OLED in combination with materials disclosed herein are exemplified below together with references that disclose those materials: CN103694277, CN1696137, EB01238981, EP01239526, EP01961743, EP1239526, EP1244155, EP1642951, EP1647554, EP1841834, EP1841834B, EP2062907, EP2730583, JP2012074444, JP2013110263, JP4478555, KR1020090133652, KR20120032054, KR20130043460, TW201332980, U.S. Ser. No. 06/699,599, U.S. Ser. No. 06/916,554, US20010019782, US20020034656, US20030068526, US20030072964, US20030138657, US20050123788, US20050244673, US2005123791, US2005260449, US20060008670, US20060065890, US20060127696, US20060134459, US20060134462, US20060202194, US20060251923, US20070034863, US20070087321, US20070103060, US20070111026, US20070190359, US20070231600, US2007034863, US2007104979, US2007104980, US2007138437, US2007224450, US2007278936, US20080020237, US20080233410, US20080261076, US20080297033, US200805851, US2008161567, US2008210930, US20090039776, US20090108737, US20090115322, US20090179555, US2009085476, US2009104472, US20100090591, US20100148663, US20100244004, US20100295032, US2010102716, US2010105902, US2010244004, US2010270916, US20110057559, US20110108822, US20110204333, US2011215710, US2011227049, US2011285275, US2012292601, US20130146848, US2013033172, US2013165653, US2013181190, US2013334521, US20140246656, US2014103305, U.S. Pat. Nos. 6,303,238, 6,413,656, 6,653,654, 6,670,645, 6,687,266, 6,835,469, 6,921,915, 7,279,704, 7,332,232, 7,378,162, 7,534,505, 7,675,228, 7,728,137, 7,740,957, 7,759,489, 7,951,947, 8,067,099, 8,592,586, 8,871,361, WO06081973, WO06121811, WO07018067, WO07108362, WO07115970, WO07115981, WO08035571, WO2002015645, WO2003040257, WO2005019373, WO2006056418, WO2008054584, WO2008078800, WO2008096609, WO2008101842, WO2009000673, WO2009050281, WO2009100991, WO2010028151, WO2010054731, WO2010086089, WO2010118029, WO2011044988, WO2011051404, WO2011107491, WO2012020327, WO2012163471, WO2013094620, WO2013107487, WO2013174471, WO2014007565, WO2014008982, WO2014023377, WO2014024131, WO2014031977, WO2014038456, WO2014112450.

HBL:

A hole blocking layer (HBL) may be used to reduce the number of holes and/or excitons that leave the emissive layer. The presence of such a blocking layer in a device may result in substantially higher efficiencies and/or longer lifetime as compared to a similar device lacking a blocking layer. Also, a blocking layer may be used to confine emission to a desired region of an OLED. In some embodiments, the HBL material has a lower HOMO (further from the vacuum level) and or higher triplet energy than the emitter closest to the HBL interface. In some embodiments, the HBL material has a lower HOMO (further from the vacuum level) and or higher triplet energy than one or more of the hosts closest to the HBL interface.

In one aspect, compound used in HBL contains the same molecule or the same functional groups used as host described above.

In another aspect, compound used in HBL contains at least one of the following groups in the molecule:

wherein k is an integer from 1 to 20; L¹⁰¹ is an another ligand, k′ is an integer from 1 to 3. ETL:

Electron transport layer (ETL) may include a material capable of transporting electrons. Electron transport layer may be intrinsic (undoped), or doped. Doping may be used to enhance conductivity. Examples of the ETL material are not particularly limited, and any metal complexes or organic compounds may be used as long as they are typically used to transport electrons.

In one aspect, compound used in ETL contains at least one of the following groups in the molecule:

wherein R¹⁰¹ is selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof, when it is aryl or heteroaryl, it has the similar definition as Ar's mentioned above. Ar¹ to Ar³ has the similar definition as Ar's mentioned above. k is an integer from 1 to 20. X¹⁰¹ to X¹⁰⁸ is selected from C (including CH) or N.

In another aspect, the metal complexes used in ETL contains, but not limit to the following general formula:

wherein (O—N) or (N—N) is a bidentate ligand, having metal coordinated to atoms O, N or N, N; L¹⁰¹ is another ligand; k′ is an integer value from 1 to the maximum number of ligands that may be attached to the metal.

Non-limiting examples of the ETL materials that may be used in an OLED in combination with materials disclosed herein are exemplified below together with references that disclose those materials: CN103508940, EP01602648, EP01734038, EP01956007, JP2004-022334, JP2005149918, JP2005-268199, KR0117693, KR20130108183, US20040036077, US20070104977, US2007018155, US20090101870, US20090115316, US20090140637, US20090179554, US2009218940, US2010108990, US2011156017, US2011210320, US2012193612, US2012214993, US2014014925, US2014014927, US20140284580, U.S. Pat. Nos. 6,656,612, 8,415,031, WO2003060956, WO2007111263, WO2009148269, WO2010067894, WO2010072300, WO2011074770, WO2011105373, WO2013079217, WO2013145667, WO2013180376, WO2014104499, WO2014104535,

Charge Generation Layer (CGL)

In tandem or stacked OLEDs, the CGL plays an essential role in the performance, which is composed of an n-doped layer and a p-doped layer for injection of electrons and holes, respectively. Electrons and holes are supplied from the CGL and electrodes. The consumed electrons and holes in the CGL are refilled by the electrons and holes injected from the cathode and anode, respectively; then, the bipolar currents reach a steady state gradually. Typical CGL materials include n and p conductivity dopants used in the transport layers.

In any above-mentioned compounds used in each layer of the OLED device, the hydrogen atoms can be partially or fully deuterated. Thus, any specifically listed substituent, such as, without limitation, methyl, phenyl, pyridyl, etc. may be undeuterated, partially deuterated, and fully deuterated versions thereof. Similarly, classes of substituents such as, without limitation, alkyl, aryl, cycloalkyl, heteroaryl, etc. also may be undeuterated, partially deuterated, and fully deuterated versions thereof.

It is understood that the various embodiments described herein are by way of example only, and are not intended to limit the scope of the invention. For example, many of the materials and structures described herein may be substituted with other materials and structures without deviating from the spirit of the invention. The present invention as claimed may therefore include variations from the particular examples and preferred embodiments described herein, as will be apparent to one of skill in the art. It is understood that various theories as to why the invention works are not intended to be limiting. 

I claim:
 1. A compound comprising a ligand L_(A) represented by Formula I:

wherein ring A is a 6-membered carbocyclic or heterocyclic ring; wherein Z is nitrogen or carbon; wherein R¹ and R³ each represent from mono-substitution to the possible maximum number of substitution, or no substitution; wherein Z¹, Z², Z³, and Z⁴ are each independently selected from the group consisting of nitrogen and carbon; wherein at least one of Z¹, Z², Z³, and Z⁴ is nitrogen; wherein X is selected from the group consisting of O, S, and Se; wherein each R¹ and R³ are independently selected from the group consisting of: (i) hydrogen, deuterium, halide, straight chain alkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; or (ii) hydrogen, deuterium, halide, isopropyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; wherein any adjacent substituents of R¹ and R³ are optionally joined or fused into a ring; wherein the ligand L_(A) is coordinated to Ir; and wherein the ligand L_(A) is optionally linked with other ligands to comprise a tridentate, tetradentate, pentadentate or hexadentate ligand.
 2. The compound of claim 1, wherein X is O.
 3. The compound of claim 1, wherein one of Z¹, Z², Z³, and Z⁴ is nitrogen, and each of three Z¹, Z², Z³, and Z⁴ is carbon.
 4. The compound of claim 1, wherein ring A is pyridine.
 5. The compound of claim 1, wherein ligand L_(A) is selected from the group consisting of:


6. The compound of claim 1, wherein ligand L_(A) is selected from the group consisting of: LA1 to LA318 based on the chemical structure

LA # R11 R12 R13 R14 R31 R32 R33 1 CD3 CD3 H H H H H 2 CD3 CH3 H H H H H 3 CD3 H 2,6DIP H H H H 4 CD3 H 2,6DMB H H H H 5 CD3 H CD3 H H H H 6 CD3 H CH3 H H H H 7 CD3 H H 2,6DIP H H H 8 CD3 H H 2,6DMB H H H 9 CD3 H H CD3 H H H 10 CD3 H H CH3 H H H 11 CD3 H H H 2,6DIP H H 12 CD3 H H H 2,6DMB H H 13 CD3 H H H CD3 H H 14 CD3 H H H CH3 H H 15 CD3 H H H H 2,6DIP H 16 CD3 H H H H 2,6DMB H 17 CD3 H H H H CD3 H 18 CD3 H H H H CH3 H 19 CD3 H H H H H 2,6DIP 20 CD3 H H H H H 2,6DMB 21 CD3 H H H H H CD3 22 CD3 H H H H H CH3 23 CD3 H H H H H H 24 CD3 H H H H H i-Pr 25 CD3 H H H H i-Pr H 26 CD3 H H H i-Pr H H 27 CD3 H H i-Pr H H H 28 CD3 H i-Pr H H H H 29 CD3 i-Pr H H H H H 30 CH3 CD3 H H H H H 31 CH3 CH3 H H H H H 32 CH3 H 2,6DIP H H H H 33 CH3 H 2,6DMB H H H H 34 CH3 H CD3 H H H H 35 CH3 H CH3 H H H H 36 CH3 H H 2,6DIP H H H 37 CH3 H H 2,6DMB H H H 38 CH3 H H CD3 H H H 39 CH3 H H CH3 H H H 40 CH3 H H H 2,6DIP H H 41 CH3 H H H 2,6DMB H H 42 CH3 H H H CD3 H H 43 CH3 H H H CH3 H H 44 CH3 H H H H 2,6DIP H 45 CH3 H H H H 2,6DMB H 46 CH3 H H H H CD3 H 47 CH3 H H H H CH3 H 48 CH3 H H H H H 2,6DIP 49 CH3 H H H H H 2,6DMB 50 CH3 H H H H H CD3 51 CH3 H H H H H CH3 52 CH3 H H H H H H 53 CH3 H H H H H i-Pr 54 CH3 H H H H i-Pr H 55 CH3 H H H i-Pr H H 56 CH3 H H i-Pr H H H 57 CH3 H i-Pr H H H H 58 CH3 i-Pr H H H H H 59 H 2,6DIP H CD3 H H H 60 H 2,6DIP H CH3 H H H 61 H 2,6DIP H H CD3 H H 62 H 2,6DIP H H CH3 H H 63 H 2,6DIP H H H CD3 H 64 H 2,6DIP H H H CH3 H 65 H 2,6DIP H H H H CD3 66 H 2,6DIP H H H H CH3 67 H 2,6DIP H H H H H 68 H 2,6DMB H CD3 H H H 69 H 2,6DMB H CH3 H H H 70 H 2,6DMB H H CD3 H H 71 H 2,6DMB H H CH3 H H 72 H 2,6DMB H H H CD3 H 73 H 2,6DMB H H H CH3 H 74 H 2,6DMB H H H H CD3 75 H 2,6DMB H H H H CH3 76 H 2,6DMB H H H H H 77 H CD3 CD3 H H H H 78 H CD3 CH3 H H H H 79 H CD3 H 2,6DIP H H H 80 H CD3 H 2,6DMB H H H 81 H CD3 H CD3 H H H 82 H CD3 H CH3 H H H 83 H CD3 H H 2,6DIP H H 84 H CD3 H H 2,6DMB H H 85 H CD3 H H CD3 H H 86 H CD3 H H CH3 H H 87 H CD3 H H H 2,6DIP H 88 H CD3 H H H 2,6DMB H 89 H CD3 H H H CD3 H 90 H CD3 H H H CH3 H 91 H CD3 H H H H 2,6DIP 92 H CD3 H H H H 2,6DMB 93 H CD3 H H H H CD3 94 H CD3 H H H H CH3 95 H CD3 H H H H H 96 H CD3 H H H H i-Pr 97 H CD3 H H H i-Pr H 98 H CD3 H H i-Pr H H 99 H CD3 H i-Pr H H H 100 H CD3 i-Pr H H H H 101 H CH3 CD3 H H H H 102 H CH3 CH3 H H H H 103 H CH3 H 2,6DIP H H H 104 H CH3 H 2,6DMB H H H 105 H CH3 H CD3 H H H 106 H CH3 H CH3 H H H 107 H CH3 H H 2,6DIP H H 108 H CH3 H H 2,6DMB H H 109 H CH3 H H CD3 H H 110 H CH3 H H CH3 H H 111 H CH3 H H H 2,6DIP H 112 H CH3 H H H 2,6DMB H 113 H CH3 H H H CD3 H 114 H CH3 H H H CH3 H 115 H CH3 H H H H 2,6DIP 116 H CH3 H H H H 2,6DMB 117 H CH3 H H H H CD3 118 H CH3 H H H H CH3 119 H CH3 H H H H H 120 H CH3 H H H H i-Pr 121 H CH3 H H H i-Pr H 122 H CH3 H H i-Pr H H 123 H CH3 H i-Pr H H H 124 H CH3 i-Pr H H H H 125 H H 2,6DIP H CD3 H H 126 H H 2,6DIP H CH3 H H 127 H H 2,6DIP H H CD3 H 128 H H 2,6DIP H H CH3 H 129 H H 2,6DIP H H H CD3 130 H H 2,6DIP H H H CH3 131 H H 2,6DIP H H H H 132 H H 2,6DMB H CD3 H H 133 H H 2,6DMB H CH3 H H 134 H H 2,6DMB H H CD3 H 135 H H 2,6DMB H H CH3 H 136 H H 2,6DMB H H H CD3 137 H H 2,6DMB H H H CH3 138 H H 2,6DMB H H H H 139 H H CD3 CD3 H H H 140 H H CD3 CH3 H H H 141 H H CD3 H 2,6DIP H H 142 H H CD3 H 2,6DMB H H 143 H H CD3 H CD3 H H 144 H H CD3 H CH3 H H 145 H H CD3 H H 2,6DIP H 146 H H CD3 H H 2,6DMB H 147 H H CD3 H H CD3 H 148 H H CD3 H H CH3 H 149 H H CD3 H H H 2,6DIP 150 H H CD3 H H H 2,6DMB 151 H H CD3 H H H CD3 152 H H CD3 H H H CH3 153 H H CD3 H H H H 154 H H CD3 H H H i-Pr 155 H H CD3 H H i-Pr H 156 H H CD3 H i-Pr H H 157 H H CD3 i-Pr H H H 158 H H CH3 CD3 H H H 159 H H CH3 CH3 H H H 160 H H CH3 H 2,6DIP H H 161 H H CH3 H 2,6DMB H H 162 H H CH3 H CD3 H H 163 H H CH3 H CH3 H H 164 H H CH3 H H 2,6DIP H 165 H H CH3 H H 2,6DMB H 166 H H CH3 H H CD3 H 167 H H CH3 H H CH3 H 168 H H CH3 H H H 2,6DIP 169 H H CH3 H H H 2,6DMB 170 H H CH3 H H H CD3 171 H H CH3 H H H CH3 172 H H CH3 H H H H 173 H H CH3 H H H i-Pr 174 H H CH3 H H i-Pr H 175 H H CH3 H i-Pr H H 176 H H CH3 i-Pr H H H 177 H H H 2,6DIP CD3 H H 178 H H H 2,6DIP CH3 H H 179 H H H 2,6DIP H CD3 H 180 H H H 2,6DIP H CH3 H 181 H H H 2,6DIP H H CD3 182 H H H 2,6DIP H H CH3 183 H H H 2,6DIP H H H 184 H H H 2,6DMB CD3 H H 185 H H H 2,6DMB CH3 H H 186 H H H 2,6DMB H CD3 H 187 H H H 2,6DMB H CH3 H 188 H H H 2,6DMB H H CD3 189 H H H 2,6DMB H H CH3 190 H H H 2,6DMB H H H 191 H H H CD3 2,6DIP H H 192 H H H CD3 2,6DMB H H 193 H H H CD3 CD3 H H 194 H H H CD3 CH3 H H 195 H H H CD3 H 2,6DIP H 196 H H H CD3 H 2,6DMB H 197 H H H CD3 H CD3 H 198 H H H CD3 H CH3 H 199 H H H CD3 H H 2,6DIP 200 H H H CD3 H H 2,6DMB 201 H H H CD3 H H CD3 202 H H H CD3 H H CH3 203 H H H CD3 H H H 204 H H H CD3 H H i-Pr 205 H H H CD3 H i-Pr H 206 H H H CD3 i-Pr H H 207 H H H CH3 2,6DIP H H 208 H H H CH3 2,6DMB H H 209 H H H CH3 CD3 H H 210 H H H CH3 CH3 H H 211 H H H CH3 H 2,6DIP H 212 H H H CH3 H 2,6DMB H 213 H H H CH3 H CD3 H 214 H H H CH3 H CH3 H 215 H H H CH3 H H 2,6DIP 216 H H H CH3 H H 2,6DMB 217 H H H CH3 H H CD3 218 H H H CH3 H H CH3 219 H H H CH3 H H H 220 H H H CH3 H H i-Pr 221 H H H CH3 H i-Pr H 222 H H H CH3 i-Pr H H 223 H H H H 2,6DIP H CD3 224 H H H H 2,6DIP H CH3 225 H H H H 2,6DIP H H 226 H H H H 2,6DMB H CD3 227 H H H H 2,6DMB H CH3 228 H H H H 2,6DMB H H 229 H H H H CD3 CD3 H 230 H H H H CD3 CH3 H 231 H H H H CD3 H 2,6DIP 232 H H H H CD3 H 2,6DMB 233 H H H H CD3 H CD3 234 H H H H CD3 H CH3 235 H H H H CD3 H H 236 H H H H CD3 H i-Pr 237 H H H H CD3 i-Pr H 238 H H H H CH3 CD3 H 239 H H H H CH3 CH3 H 240 H H H H CH3 H 2,6DIP 241 H H H H CH3 H 2,6DMB 242 H H H H CH3 H CD3 243 H H H H CH3 H CH3 244 H H H H CH3 H H 245 H H H H CH3 H i-Pr 246 H H H H CH3 i-Pr H 247 H H H H H 2,6DIP CD3 248 H H H H H 2,6DIP CH3 249 H H H H H 2,6DIP H 250 H H H H H 2,6DMB CD3 251 H H H H H 2,6DMB CH3 252 H H H H H 2,6DMB H 253 H H H H H CD3 2,6DIP 254 H H H H H CD3 2,6DMB 255 H H H H H CD3 CD3 256 H H H H H CD3 CH3 257 H H H H H CD3 H 258 H H H H H CD3 i-Pr 259 H H H H H CH3 2,6DIP 260 H H H H H CH3 2,6DMB 261 H H H H H CH3 CD3 262 H H H H H CH3 CH3 263 H H H H H CH3 H 264 H H H H H CH3 i-Pr 265 H H H H H H 2,6DIP 266 H H H H H H 2,6DMB 267 H H H H H H CD3 268 H H H H H H CH3 269 H H H H H H H 270 H H H H H H i-Pr 271 H H H H H i-Pr CD3 272 H H H H H i-Pr CH3 273 H H H H H i-Pr H 274 H H H H i-Pr CD3 H 275 H H H H i-Pr CH3 H 276 H H H H i-Pr H CD3 277 H H H H i-Pr H CH3 278 H H H H i-Pr H H 279 H H H i-Pr CD3 H H 280 H H H i-Pr CH3 H H 281 H H H i-Pr H CD3 H 282 H H H i-Pr H CH3 H 283 H H H i-Pr H H CD3 284 H H H i-Pr H H CH3 285 H H H i-Pr H H H 286 H H i-Pr CD3 H H H 287 H H i-Pr CH3 H H H 288 H H i-Pr H CD3 H H 289 H H i-Pr H CH3 H H 290 H H i-Pr H H CD3 H 291 H H i-Pr H H CH3 H 292 H H i-Pr H H H CD3 293 H H i-Pr H H H CH3 294 H H i-Pr H H H H 295 H i-Pr CD3 H H H H 296 H i-Pr CH3 H H H H 297 H i-Pr H CD3 H H H 298 H i-Pr H CH3 H H H 299 H i-Pr H H CD3 H H 300 H i-Pr H H CH3 H H 301 H i-Pr H H H CD3 H 302 H i-Pr H H H CH3 H 303 H i-Pr H H H H CD3 304 H i-Pr H H H H CH3 305 H i-Pr H H H H H 306 i-Pr CD3 H H H H H 307 i-Pr CH3 H H H H H 308 i-Pr H CD3 H H H H 309 i-Pr H CH3 H H H H 310 i-Pr H H CD3 H H H 311 i-Pr H H CH3 H H H 312 i-Pr H H H CD3 H H 313 i-Pr H H H CH3 H H 314 i-Pr H H H H CD3 H 315 i-Pr H H H H CH3 H 316 i-Pr H H H H H CD3 317 i-Pr H H H H H CH3 318 i-Pr H H H H H H

LA319 to LA628 based on the structure:

LA # R11 R12 R13 R14 R31 R32 R34 319 CD3 CD3 H H H H H 320 CD3 CH3 H H H H H 321 CD3 H 2,6DIP H H H H 322 CD3 H 2,6DMB H H H H 323 CD3 H CD3 H H H H 324 CD3 H CH3 H H H H 325 CD3 H H 2,6DIP H H H 326 CD3 H H 2,6DMB H H H 327 CD3 H H CD3 H H H 328 CD3 H H CH3 H H H 329 CD3 H H H 2,6DIP H H 330 CD3 H H H 2,6DMB H H 331 CD3 H H H CD3 H H 332 CD3 H H H CH3 H H 333 CD3 H H H H 2,6DIP H 334 CD3 H H H H 2.6DMB H 335 CD3 H H H H CD3 H 336 CD3 H H H H CH3 H 337 CD3 H H H H H 2,6DIP 338 CD3 H H H H H 2,6DMB 339 CD3 H H H H H CD3 340 CD3 H H H H H CH3 341 CD3 H H H H H H 342 CD3 H H H H H i-Pr 343 CD3 H H H H i-Pr H 344 CD3 H H H i-Pr H H 345 CD3 H H i-Pr H H H 346 CD3 H i-Pr H H H H 347 CD3 i-Pr H H H H H 348 CH3 CD3 H H H H H 349 CH3 CH3 H H H H H 350 CH3 H 2,6DIP H H H H 351 CH3 H 2,6DMB H H H H 352 CH3 H CD3 H H H H 353 CH3 H CH3 H H H H 354 CH3 H H 2,6DIP H H H 355 CH3 H H 2,6DMB H H H 356 CH3 H H CD3 H H H 357 CH3 H H CH3 H H H 358 CH3 H H H 2,6DIP H H 359 CH3 H H H 2,6DMB H H 360 CH3 H H H CD3 H H 361 CH3 H H H CH3 H H 362 CH3 H H H H 2,6DIP H 363 CH3 H H H H 2,6DMB H 364 CH3 H H H H CD3 H 365 CH3 H H H H CH3 H 366 CH3 H H H H H 2,6DIP 367 CH3 H H H H H 2,6DMB 368 CH3 H H H H H CD3 369 CH3 H H H H H CH3 370 CH3 H H H H H H 371 CH3 H H H H H i-Pr 372 CH3 H H H H i-Pr H 373 CH3 H H H i-Pr H H 374 CH3 H H i-Pr H H H 375 CH3 H i-Pr H H H H 376 CH3 i-Pr H H H H H 377 H 2,6DIP H CD3 H H H 378 H 2,6DIP H CH3 H H H 379 H 2,6DIP H H CD3 H H 380 H 2,6DIP H H CH3 H H 381 H 2,6DIP H H H CD3 H 382 H 2,6DIP H H H CH3 H 383 H 2,6DIP H H H H CD3 384 H 2,6DIP H H H H CH3 385 H 2,6DIP H H H H H 386 H 2,6DMB H CD3 H H H 387 H 2,6DMB H CH3 H H H 388 H 2,6DMB H H CD3 H H 389 H 2,6DMB H H CH3 H H 390 H 2,6DMB H H H CD3 H 391 H 2,6DMB H H H CH3 H 392 H 2,6DMB H H H H CD3 393 H 2,6DMB H H H H CH3 394 H 2,6DMB H H H H H 395 H CD3 CD3 H H H H 396 H CD3 CH3 H H H H 397 H CD3 H 2,6DIP H H H 398 H CD3 H 2,6DMB H H H 399 H CD3 H CD3 H H H 400 H CD3 H CH3 H H H 401 H CD3 H H 2,6DIP H H 402 H CD3 H H 2,6DMB H H 403 H CD3 H H CD3 H H 404 H CD3 H H CH3 H H 405 H CD3 H H H 2,6DIP H 406 H CD3 H H H 2,6DMB H 407 H CD3 H H H CD3 H 408 H CD3 H H H CH3 H 409 H CD3 H H H H 2,6DIP 410 H CD3 H H H H 2,6DMB 411 H CD3 H H H H CD3 412 H CD3 H H H H CH3 413 H CD3 H H H H H 414 H CD3 H H H H i-Pr 415 H CD3 H H H i-Pr H 416 H CD3 H H i-Pr H H 417 H CD3 H i-Pr H H H 418 H CD3 i-Pr H H H H 419 H CH3 CD3 H H H H 420 H CH3 CH3 H H H H 421 H CH3 H 2,6DIP H H H 422 H CH3 H 2,6DMB H H H 423 H CH3 H CD3 H H H 424 H CH3 H CH3 H H H 425 H CH3 H H 2,6DIP H H 426 H CH3 H H 2,6DMB H H 427 H CH3 H H CD3 H H 428 H CH3 H H CH3 H H 429 H CH3 H H H 2,6DIP H 430 H CH3 H H H 2,6DMB H 431 H CH3 H H H CD3 H 432 H CH3 H H H CH3 H 433 H CH3 H H H H 2,6DIP 434 H CH3 H H H H 2,6DMB 435 H CH3 H H H H CD3 436 H CH3 H H H H CH3 437 H CH3 H H H H H 438 H CH3 H H H H i-Pr 439 H CH3 H H H i-Pr H 440 H CH3 H H i-Pr H H 441 H CH3 H i-Pr H H H 442 H CH3 i-Pr H H H H 443 H H 2,6DIP H CD3 H H 444 H H 2,6DIP H CH3 H H 445 H H 2,6DIP H H CD3 H 446 H H 2,6DIP H H CH3 H 447 H H 2,6DIP H H H CD3 448 H H 2,6DIP H H H CH3 449 H H 2,6DIP H H H H 450 H H 2,6DMB H CD3 H H 451 H H 2,6DMB H CH3 H H 452 H H 2,6DMB H H CD3 H 453 H H 2,6DMB H H CH3 H 454 H H 2,6DMB H H H CD3 455 H H 2,6DMB H H H CH3 456 H H 2,6DMB H H H H 457 H H CD3 CD3 H H H 458 H H CD3 CH3 H H H 459 H H CD3 H 2,6DIP H H 460 H H CD3 H 2,6DMB H H 461 H H CD3 H CD3 H H 462 H H CD3 H CH3 H H 463 H H CD3 H H 2,6DIP H 464 H H CD3 H H 2,6DMB H 465 H H CD3 H H CD3 H 466 H H CD3 H H CH3 H 467 H H CD3 H H H 2,6DIP 468 H H CD3 H H H 2,6DMB 469 H H CD3 H H H CD3 470 H H CD3 H H H CH3 471 H H CD3 H H H H 472 H H CD3 H H H i-Pr 473 H H CD3 H H i-Pr H 474 H H CD3 H i-Pr H H 475 H H CD3 i-Pr H H H 476 H H CH3 CD3 H H H 477 H H CH3 CH3 H H H 478 H H CH3 H 2,6DIP H H 479 H H CH3 H 2,6DMB H H 480 H H CH3 H CD3 H H 481 H H CH3 H CH3 H H 482 H H CH3 H H 2,6DIP H 483 H H CH3 H H 2,6DMB H 484 H H CH3 H H CD3 H 485 H H CH3 H H CH3 H 486 H H CH3 H H H 2,6DIP 487 H H CH3 H H H 2,6DMB 488 H H CH3 H H H CD3 489 H H CH3 H H H CH3 490 H H CH3 H H H H 491 H H CH3 H H H i-Pr 492 H H CH3 H H i-Pr H 493 H H CH3 H i-Pr H H 494 H H CH3 i-Pr H H H 495 H H H 2,6DIP H CD3 H 496 H H H 2,6DIP H CH3 H 497 H H H 2,6DIP H H CD3 498 H H H 2,6DIP H H CH3 499 H H H 2,6DIP H H H 500 H H H 2,6DMB H CD3 H 501 H H H 2,6DMB H CH3 H 502 H H H 2,6DMB H H CD3 503 H H H 2,6DMB H H CH3 504 H H H 2,6DMB H H H 505 H H H CD3 CD3 H H 506 H H H CD3 CH3 H H 507 H H H CD3 H 2,6DIP H 508 H H H CD3 H 2,6DMB H 509 H H H CD3 H CD3 H 510 H H H CD3 H CH3 H 511 H H H CD3 H H 2,6DIP 512 H H H CD3 H H 2,6DMB 513 H H H CD3 H H CD3 514 H H H CD3 H H CH3 515 H H H CD3 H H H 516 H H H CD3 H H i-Pr 517 H H H CD3 H i-Pr H 518 H H H CD3 i-Pr H H 519 H H H CH3 CD3 H H 520 H H H CH3 CH3 H H 521 H H H CH3 H 2,6DIP H 522 H H H CH3 H 2,6DMB H 523 H H H CH3 H CD3 H 524 H H H CH3 H CH3 H 525 H H H CH3 H H 2,6DIP 526 H H H CH3 H H 2,6DMB 527 H H H CH3 H H CD3 528 H H H CH3 H H CH3 529 H H H CH3 H H H 530 H H H CH3 H H i-Pr 531 H H H CH3 H i-Pr H 532 H H H CH3 i-Pr H H 533 H H H H 2,6DIP H CD3 534 H H H H 2,6DIP H CH3 535 H H H H 2,6DIP H H 536 H H H H 2,6DMB H CD3 537 H H H H 2,6DMB H CH3 538 H H H H 2,6DMB H H 539 H H H H CD3 CD3 H 540 H H H H CD3 CH3 H 541 H H H H CD3 H 2,6DIP 542 H H H H CD3 H 2,6DMB 543 H H H H CD3 H CD3 544 H H H H CD3 H CH3 545 H H H H CD3 H H 546 H H H H CD3 H i-Pr 547 H H H H CD3 i-Pr H 548 H H H H CH3 CD3 H 549 H H H H CH3 CH3 H 550 H H H H CH3 H 2,6DIP 551 H H H H CH3 H 2,6DMB 552 H H H H CH3 H CD3 553 H H H H CH3 H CH3 554 H H H H CH3 H H 555 H H H H CH3 H i-Pr 556 H H H H CH3 i-Pr H 557 H H H H H 2,6DIP CD3 558 H H H H H 2,6DIP CH3 559 H H H H H 2,6DIP H 560 H H H H H 2,6DMB CD3 561 H H H H H 2,6DMB CH3 562 H H H H H 2,6DMB H 563 H H H H H CD3 2,6DIP 564 H H H H H CD3 2,6DMB 565 H H H H H CD3 CD3 566 H H H H H CD3 CH3 567 H H H H H CD3 H 568 H H H H H CD3 i-Pr 569 H H H H H CH3 2,6DIP 570 H H H H H CH3 2,6DMB 571 H H H H H CH3 CD3 572 H H H H H CH3 CH3 573 H H H H H CH3 H 574 H H H H H CH3 i-Pr 575 H H H H H H 2,6DIP 576 H H H H H H 2,6DMB 577 H H H H H H CD3 578 H H H H H H CH3 579 H H H H H H H 580 H H H H H H i-Pr 581 H H H H H i-Pr CD3 582 H H H H H i-Pr CH3 583 H H H H H i-Pr H 584 H H H H i-Pr CD3 H 585 H H H H i-Pr CH3 H 586 H H H H i-Pr H CD3 587 H H H H i-Pr H CH3 588 H H H H i-Pr H H 589 H H H i-Pr CD3 H H 590 H H H i-Pr CH3 H H 591 H H H i-Pr H CD3 H 592 H H H i-Pr H CH3 H 593 H H H i-Pr H H CD3 594 H H H i-Pr H H CH3 595 H H H i-Pr H H H 596 H H i-Pr CD3 H H H 597 H H i-Pr CH3 H H H 598 H H i-Pr H CD3 H H 599 H H i-Pr H CH3 H H 600 H H i-Pr H H CD3 H 601 H H i-Pr H H CH3 H 602 H H i-Pr H H H CD3 603 H H i-Pr H H H CH3 604 H H i-Pr H H H H 605 H i-Pr CD3 H H H H 606 H i-Pr CH3 H H H H 607 H i-Pr H CD3 H H H 608 H i-Pr H CH3 H H H 609 H i-Pr H H CD3 H H 610 H i-Pr H H CH3 H H 611 H i-Pr H H H CD3 H 612 H i-Pr H H H CH3 H 613 H i-Pr H H H H CD3 614 H i-Pr H H H H CH3 615 H i-Pr H H H H H 616 i-Pr CD3 H H H H H 617 i-Pr CH3 H H H H H 618 i-Pr H CD3 H H H H 619 i-Pr H CH3 H H H H 620 i-Pr H H CD3 H H H 621 i-Pr H H CH3 H H H 622 i-Pr H H H CD3 H H 623 i-Pr H H H CH3 H H 624 i-Pr H H H H CD3 H 625 i-Pr H H H H CH3 H 626 i-Pr H H H H H CD3 627 i-Pr H H H H H CH3 628 i-Pr H H H H H H

LA629 to LA938 based on the structure:

LA # R11 R12 R13 R14 R31 R33 R34 629 CD3 CD3 H H H H H 630 CD3 CH3 H H H H H 631 CD3 H 2,6DIP H H H H 632 CD3 H 2,6DMB H H H H 633 CD3 H CD3 H H H H 634 CD3 H CH3 H H H H 635 CD3 H H 2,6DIP H H H 636 CD3 H H 2,6DMB H H H 637 CD3 H H CD3 H H H 638 CD3 H H CH3 H H H 639 CD3 H H H 2,6DIP H H 640 CD3 H H H 2,6DMB H H 641 CD3 H H H CD3 H H 642 CD3 H H H CH3 H H 643 CD3 H H H H 2,6DIP H 644 CD3 H H H H 2,6DMB H 645 CD3 H H H H CD3 H 646 CD3 H H H H CH3 H 647 CD3 H H H H H 2,6DIP 648 CD3 H H H H H 2,6DMB 649 CD3 H H H H H CD3 650 CD3 H H H H H CH3 651 CD3 H H H H H H 652 CD3 H H H H H i-Pr 653 CD3 H H H H i-Pr H 654 CD3 H H H i-Pr H H 655 CD3 H H i-Pr H H H 656 CD3 H i-Pr H H H H 657 CD3 i-Pr H H H H H 658 CH3 CD3 H H H H H 659 CH3 CH3 H H H H H 660 CH3 H 2,6DIP H H H H 661 CH3 H 2,6DMB H H H H 662 CH3 H CD3 H H H H 663 CH3 H CH3 H H H H 664 CH3 H H 2,6DIP H H H 665 CH3 H H 2,6DMB H H H 666 CH3 H H CD3 H H H 667 CH3 H H CH3 H H H 668 CH3 H H H 2,6DIP H H 669 CH3 H H H 2,6DMB H H 670 CH3 H H H CD3 H H 671 CH3 H H H CH3 H H 672 CH3 H H H H 2,6DIP H 673 CH3 H H H H 2,6DMB H 674 CH3 H H H H CD3 H 675 CH3 H H H H CH3 H 676 CH3 H H H H H 2,6DIP 677 CH3 H H H H H 2,6DMB 678 CH3 H H H H H CD3 679 CH3 H H H H H CH3 680 CH3 H H H H H H 681 CH3 H H H H H i-Pr 682 CH3 H H H H i-Pr H 683 CH3 H H H i-Pr H H 684 CH3 H H i-Pr H H H 685 CH3 H i-Pr H H H H 686 CH3 i-Pr H H H H H 687 H 2,6DIP H CD3 H H H 688 H 2,6DIP H CH3 H H H 689 H 2,6DIP H H CD3 H H 690 H 2,6DIP H H CH3 H H 691 H 2,6DIP H H H CD3 H 692 H 2,6DIP H H H CH3 H 693 H 2,6DIP H H H H CD3 694 H 2,6DIP H H H H CH3 695 H 2,6DIP H H H H H 696 H 2,6DMB H CD3 H H H 697 H 2,6DMB H CH3 H H H 698 H 2,6DMB H H CD3 H H 699 H 2,6DMB H H CH3 H H 700 H 2,6DMB H H H CD3 H 701 H 2,6DMB H H H CH3 H 702 H 2,6DMB H H H H CD3 703 H 2,6DMB H H H H CH3 704 H 2,6DMB H H H H H 705 H CD3 CD3 H H H H 706 H CD3 CH3 H H H H 707 H CD3 H 2,6DIP H H H 708 H CD3 H 2,6DMB H H H 709 H CD3 H CD3 H H H 710 H CD3 H CH3 H H H 711 H CD3 H H 2,6DIP H H 712 H CD3 H H 2,6DMB H H 713 H CD3 H H CD3 H H 714 H CD3 H H CH3 H H 715 H CD3 H H H 2,6DIP H 716 H CD3 H H H 2,6DMB H 717 H CD3 H H H CD3 H 718 H CD3 H H H CH3 H 719 H CD3 H H H H 2,6DIP 720 H CD3 H H H H 2,6DMB 721 H CD3 H H H H CD3 722 H CD3 H H H H CH3 723 H CD3 H H H H H 724 H CD3 H H H H i-Pr 725 H CD3 H H H i-Pr H 726 H CD3 H H i-Pr H H 727 H CD3 H i-Pr H H H 728 H CD3 i-Pr H H H H 729 H CH3 CD3 H H H H 730 H CH3 CH3 H H H H 731 H CH3 H 2,6DIP H H H 732 H CH3 H 2,6DMB H H H 733 H CH3 H CD3 H H H 734 H CH3 H CH3 H H H 735 H CH3 H H 2,6DIP H H 736 H CH3 H H 2,6DMB H H 737 H CH3 H H CD3 H H 738 H CH3 H H CH3 H H 739 H CH3 H H H 2,6DIP H 740 H CH3 H H H 2,6DMB H 741 H CH3 H H H CD3 H 742 H CH3 H H H CH3 H 743 H CH3 H H H H 2,6DIP 744 H CH3 H H H H 2,6DMB 745 H CH3 H H H H CD3 746 H CH3 H H H H CH3 747 H CH3 H H H H H 748 H CH3 H H H H i-Pr 749 H CH3 H H H i-Pr H 750 H CH3 H H i-Pr H H 751 H CH3 H i-Pr H H H 752 H CH3 i-Pr H H H H 753 H H 2,6DIP H CD3 H H 754 H H 2,6DIP H CH3 H H 755 H H 2,6DIP H H CD3 H 756 H H 2,6DIP H H CH3 H 757 H H 2,6DIP H H H CD3 758 H H 2,6DIP H H H CH3 759 H H 2,6DIP H H H H 760 H H 2,6DMB H CD3 H H 761 H H 2,6DMB H CH3 H H 762 H H 2,6DMB H H CD3 H 763 H H 2,6DMB H H CH3 H 764 H H 2,6DMB H H H CD3 765 H H 2,6DMB H H H CH3 766 H H 2,6DMB H H H H 767 H H CD3 CD3 H H H 768 H H CD3 CH3 H H H 769 H H CD3 H 2,6DIP H H 770 H H CD3 H 2,6DMB H H 771 H H CD3 H CD3 H H 772 H H CD3 H CH3 H H 773 H H CD3 H H 2,6DIP H 774 H H CD3 H H 2,6DMB H 775 H H CD3 H H CD3 H 776 H H CD3 H H CH3 H 777 H H CD3 H H H 2,6DIP 778 H H CD3 H H H 2,6DMB 779 H H CD3 H H H CD3 780 H H CD3 H H H CH3 781 H H CD3 H H H H 782 H H CD3 H H H i-Pr 783 H H CD3 H H i-Pr H 784 H H CD3 H i-Pr H H 785 H H CD3 i-Pr H H H 786 H H CH3 CD3 H H H 787 H H CH3 CH3 H H H 788 H H CH3 H 2,6DIP H H 789 H H CH3 H 2,6DMB H H 790 H H CH3 H CD3 H H 791 H H CH3 H CH3 H H 792 H H CH3 H H 2,6DIP H 793 H H CH3 H H 2,6DMB H 794 H H CH3 H H CD3 H 795 H H CH3 H H CH3 H 796 H H CH3 H H H 2,6DIP 797 H H CH3 H H H 2,6DMB 798 H H CH3 H H H CD3 799 H H CH3 H H H CH3 800 H H CH3 H H H H 801 H H CH3 H H H i-Pr 802 H H CH3 H H i-Pr H 803 H H CH3 H i-Pr H H 804 H H CH3 i-Pr H H H 805 H H H 2,6DIP H CD3 H 806 H H H 2,6DIP H CH3 H 807 H H H 2,6DIP H H CD3 808 H H H 2,6DIP H H CH3 809 H H H 2,6DIP H H H 810 H H H 2,6DMB H CD3 H 811 H H H 2,6DMB H CH3 H 812 H H H 2,6DMB H H CD3 813 H H H 2,6DMB H H CH3 814 H H H 2,6DMB H H H 815 H H H CD3 CD3 H H 816 H H H CD3 CH3 H H 817 H H H CD3 H 2,6DIP H 818 H H H CD3 H 2,6DMB H 819 H H H CD3 H CD3 H 820 H H H CD3 H CH3 H 821 H H H CD3 H H 2,6DIP 822 H H H CD3 H H 2,6DMB 823 H H H CD3 H H CD3 824 H H H CD3 H H CH3 825 H H H CD3 H H H 826 H H H CD3 H H i-Pr 827 H H H CD3 H i-Pr H 828 H H H CD3 i-Pr H H 829 H H H CH3 CD3 H H 830 H H H CH3 CH3 H H 831 H H H CH3 H 2,6DIP H 832 H H H CH3 H 2,6DMB H 833 H H H CH3 H CD3 H 834 H H H CH3 H CH3 H 835 H H H CH3 H H 2,6DIP 836 H H H CH3 H H 2,6DMB 837 H H H CH3 H H CD3 838 H H H CH3 H H CH3 839 H H H CH3 H H H 840 H H H CH3 H H i-Pr 841 H H H CH3 H i-Pr H 842 H H H CH3 i-Pr H H 843 H H H H 2,6DIP CD3 H 844 H H H H 2,6DIP CH3 H 845 H H H H 2,6DIP H CD3 846 H H H H 2,6DIP H CH3 847 H H H H 2,6DIP H H 848 H H H H 2,6DMB CD3 H 849 H H H H 2,6DMB CH3 H 850 H H H H 2,6DMB H CD3 851 H H H H 2,6DMB H CH3 852 H H H H 2,6DMB H H 853 H H H H CD3 2,6DIP H 854 H H H H CD3 2,6DMB H 855 H H H H CD3 CD3 H 856 H H H H CD3 CH3 H 857 H H H H CD3 H 2,6DIP 858 H H H H CD3 H 2,6DMB 859 H H H H CD3 H CD3 860 H H H H CD3 H CH3 861 H H H H CD3 H H 862 H H H H CD3 H i-Pr 863 H H H H CD3 i-Pr H 864 H H H H CH3 2,6DIP H 865 H H H H CH3 2,6DMB H 866 H H H H CH3 CD3 H 867 H H H H CH3 CH3 H 868 H H H H CH3 H 2,6DIP 869 H H H H CH3 H 2,6DMB 870 H H H H CH3 H CD3 871 H H H H CH3 H CH3 872 H H H H CH3 H H 873 H H H H CH3 H i-Pr 874 H H H H CH3 i-Pr H 875 H H H H H 2,6DIP H 876 H H H H H 2,6DMB H 877 H H H H H CD3 CD3 878 H H H H H CD3 CH3 879 H H H H H CD3 H 880 H H H H H CD3 i-Pr 881 H H H H H CH3 CD3 882 H H H H H CH3 CH3 883 H H H H H CH3 H 884 H H H H H CH3 i-Pr 885 H H H H H H 2,6DIP 886 H H H H H H 2,6DMB 887 H H H H H H CD3 888 H H H H H H CH3 889 H H H H H H H 890 H H H H H H i-Pr 891 H H H H H i-Pr CD3 892 H H H H H i-Pr CH3 893 H H H H H i-Pr H 894 H H H H i-Pr CD3 H 895 H H H H i-Pr CH3 H 896 H H H H i-Pr H CD3 897 H H H H i-Pr H CH3 898 H H H H i-Pr H H 899 H H H i-Pr CD3 H H 900 H H H i-Pr CH3 H H 901 H H H i-Pr H CD3 H 902 H H H i-Pr H CH3 H 903 H H H i-Pr H H CD3 904 H H H i-Pr H H CH3 905 H H H i-Pr H H H 906 H H i-Pr CD3 H H H 907 H H i-Pr CH3 H H H 908 H H i-Pr H CD3 H H 909 H H i-Pr H CH3 H H 910 H H i-Pr H H CD3 H 911 H H i-Pr H H CH3 H 912 H H i-Pr H H H CD3 913 H H i-Pr H H H CH3 914 H H i-Pr H H H H 915 H i-Pr CD3 H H H H 916 H i-Pr CH3 H H H H 917 H i-Pr H CD3 H H H 918 H i-Pr H CH3 H H H 919 H i-Pr H H CD3 H H 920 H i-Pr H H CH3 H H 921 H i-Pr H H H CD3 H 922 H i-Pr H H H CH3 H 923 H i-Pr H H H H CD3 924 H i-Pr H H H H CH3 925 H i-Pr H H H H H 926 i-Pr CD3 H H H H H 927 i-Pr CH3 H H H H H 928 i-Pr H CD3 H H H H 929 i-Pr H CH3 H H H H 930 i-Pr H H CD3 H H H 931 i-Pr H H CH3 H H H 932 i-Pr H H H CD3 H H 933 i-Pr H H H CH3 H H 934 i-Pr H H H H CD3 H 935 i-Pr H H H H CH3 H 936 i-Pr H H H H H CD3 937 i-Pr H H H H H CH3 938 i-Pr H H H H H H

LA939 to LA1248 based on the structure:

LA # R11 R12 R13 R14 R32 R33 R34 939 CD3 CD3 H H H H H 940 CD3 CH3 H H H H H 941 CD3 H 2,6DIP H H H H 942 CD3 H 2,6DMB H H H H 943 CD3 H CD3 H H H H 944 CD3 H CH3 H H H H 945 CD3 H H 2,6DIP H H H 946 CD3 H H 2,6DMB H H H 947 CD3 H H CD3 H H H 948 CD3 H H CH3 H H H 949 CD3 H H H 2,6DIP H H 950 CD3 H H H 2,6DMB H H 951 CD3 H H H CD3 H H 952 CD3 H H H CH3 H H 953 CD3 H H H H 2,6DIP H 954 CD3 H H H H 2,6DMB H 955 CD3 H H H H CD3 H 956 CD3 H H H H CH3 H 957 CD3 H H H H H 2,6DIP 958 CD3 H H H H H 2,6DMB 959 CD3 H H H H H CD3 960 CD3 H H H H H CH3 961 CD3 H H H H H H 962 CD3 H H H H H i-Pr 963 CD3 H H H H i-Pr H 964 CD3 H H H i-Pr H H 965 CD3 H H i-Pr H H H 966 CD3 H i-Pr H H H H 967 CD3 i-Pr H H H H H 968 CH3 CD3 H H H H H 969 CH3 CH3 H H H H H 970 CH3 H 2,6DIP H H H H 971 CH3 H 2,6DMB H H H H 972 CH3 H CD3 H H H H 973 CH3 H CH3 H H H H 974 CH3 H H 2,6DIP H H H 975 CH3 H H 2,6DMB H H H 976 CH3 H H CD3 H H H 977 CH3 H H CH3 H H H 978 CH3 H H H 2,6DIP H H 979 CH3 H H H 2,6DMB H H 980 CH3 H H H CD3 H H 981 CH3 H H H CH3 H H 982 CH3 H H H H 2,6DIP H 983 CH3 H H H H 2,6DMB H 984 CH3 H H H H CD3 H 985 CH3 H H H H CH3 H 986 CH3 H H H H H 2,6DIP 987 CH3 H H H H H 2,6DMB 988 CH3 H H H H H CD3 989 CH3 H H H H H CH3 990 CH3 H H H H H H 991 CH3 H H H H H i-Pr 992 CH3 H H H H i-Pr H 993 CH3 H H H i-Pr H H 994 CH3 H H i-Pr H H H 995 CH3 H i-Pr H H H H 996 CH3 i-Pr H H H H H 997 H 2,6DIP H CD3 H H H 998 H 2,6DIP H CH3 H H H 999 H 2,6DIP H H CD3 H H 1000 H 2,6DIP H H CH3 H H 1001 H 2,6DIP H H H CD3 H 1002 H 2,6DIP H H H CH3 H 1003 H 2,6DIP H H H H CD3 1004 H 2,6DIP H H H H CH3 1005 H 2,6DIP H H H H H 1006 H 2,6DMB H CD3 H H H 1007 H 2,6DMB H CH3 H H H 1008 H 2,6DMB H H CD3 H H 1009 H 2,6DMB H H CH3 H H 1010 H 2,6DMB H H H CD3 H 1011 H 2,6DMB H H H CH3 H 1012 H 2,6DMB H H H H CD3 1013 H 2,6DMB H H H H CH3 1014 H 2,6DMB H H H H H 1015 H CD3 CD3 H H H H 1016 H CD3 CH3 H H H H 1017 H CD3 H 2,6DIP H H H 1018 H CD3 H 2,6DMB H H H 1019 H CD3 H CD3 H H H 1020 H CD3 H CH3 H H H 1021 H CD3 H H 2,6DIP H H 1022 H CD3 H H 2,6DMB H H 1023 H CD3 H H CD3 H H 1024 H CD3 H H CH3 H H 1025 H CD3 H H H 2,6DIP H 1026 H CD3 H H H 2,6DMB H 1027 H CD3 H H H CD3 H 1028 H CD3 H H H CH3 H 1029 H CD3 H H H H 2,6DIP 1030 H CD3 H H H H 2,6DMB 1031 H CD3 H H H H CD3 1032 H CD3 H H H H CH3 1033 H CD3 H H H H H 1034 H CD3 H H H H i-Pr 1035 H CD3 H H H i-Pr H 1036 H CD3 H H i-Pr H H 1037 H CD3 H i-Pr H H H 1038 H CD3 i-Pr H H H H 1039 H CH3 CD3 H H H H 1040 H CH3 CH3 H H H H 1041 H CH3 H 2,6DIP H H H 1042 H CH3 H 2,6DMB H H H 1043 H CH3 H CD3 H H H 1044 H CH3 H CH3 H H H 1045 H CH3 H H 2,6DIP H H 1046 H CH3 H H 2,6DMB H H 1047 H CH3 H H CD3 H H 1048 H CH3 H H CH3 H H 1049 H CH3 H H H 2,6DIP H 1050 H CH3 H H H 2,6DMB H 1051 H CH3 H H H CD3 H 1052 H CH3 H H H CH3 H 1053 H CH3 H H H H 2,6DIP 1054 H CH3 H H H H 2,6DMB 1055 H CH3 H H H H CD3 1056 H CH3 H H H H CH3 1057 H CH3 H H H H H 1058 H CH3 H H H H i-Pr 1059 H CH3 H H H i-Pr H 1060 H CH3 H H i-Pr H H 1061 H CH3 H i-Pr H H H 1062 H CH3 i-Pr H H H H 1063 H H 2,6DIP H CD3 H H 1064 H H 2,6DIP H CH3 H H 1065 H H 2,6DIP H H CD3 H 1066 H H 2,6DIP H H CH3 H 1067 H H 2,6DIP H H H CD3 1068 H H 2,6DIP H H H CH3 1069 H H 2,6DIP H H H H 1070 H H 2,6DMB H CD3 H H 1071 H H 2,6DMB H CH3 H H 1072 H H 2,6DMB H H CD3 H 1073 H H 2,6DMB H H CH3 H 1074 H H 2,6DMB H H H CD3 1075 H H 2,6DMB H H H CH3 1076 H H 2,6DMB H H H H 1077 H H CD3 CD3 H H H 1078 H H CD3 CH3 H H H 1079 H H CD3 H 2,6DIP H H 1080 H H CD3 H 2,6DMB H H 1081 H H CD3 H CD3 H H 1082 H H CD3 H CH3 H H 1083 H H CD3 H H 2,6DIP H 1084 H H CD3 H H 2,6DMB H 1085 H H CD3 H H CD3 H 1086 H H CD3 H H CH3 H 1087 H H CD3 H H H 2,6DIP 1088 H H CD3 H H H 2,6DMB 1089 H H CD3 H H H CD3 1090 H H CD3 H H H CH3 1091 H H CD3 H H H H 1092 H H CD3 H H H i-Pr 1093 H H CD3 H H i-Pr H 1094 H H CD3 H i-Pr H H 1095 H H CD3 i-Pr H H H 1096 H H CH3 CD3 H H H 1097 H H CH3 CH3 H H H 1098 H H CH3 H 2,6DIP H H 1099 H H CH3 H 2,6DMB H H 1100 H H CH3 H CD3 H H 1101 H H CH3 H CH3 H H 1102 H H CH3 H H 2,6DIP H 1103 H H CH3 H H 2,6DMB H 1104 H H CH3 H H CD3 H 1105 H H CH3 H H CH3 H 1106 H H CH3 H H H 2,6DIP 1107 H H CH3 H H H 2,6DMB 1108 H H CH3 H H H CD3 1109 H H CH3 H H H CH3 1110 H H CH3 H H H H 1111 H H CH3 H H H i-Pr 1112 H H CH3 H H i-Pr H 1113 H H CH3 H i-Pr H H 1114 H H CH3 i-Pr H H H 1115 H H H 2,6DIP CD3 H H 1116 H H H 2,6DIP CH3 H H 1117 H H H 2,6DIP H CD3 H 1118 H H H 2,6DIP H CH3 H 1119 H H H 2,6DIP H H CD3 1120 H H H 2,6DIP H H CH3 1121 H H H 2,6DIP H H H 1122 H H H 2,6DMB CD3 H H 1123 H H H 2,6DMB CH3 H H 1124 H H H 2,6DMB H CD3 H 1125 H H H 2,6DMB H CH3 H 1126 H H H 2,6DMB H H CD3 1127 H H H 2,6DMB H H CH3 1128 H H H 2,6DMB H H H 1129 H H H CD3 2,6DIP H H 1130 H H H CD3 2,6DMB H H 1131 H H H CD3 CD3 H H 1132 H H H CD3 CH3 H H 1133 H H H CD3 H 2,6DIP H 1134 H H H CD3 H 2,6DMB H 1135 H H H CD3 H CD3 H 1136 H H H CD3 H CH3 H 1137 H H H CD3 H H 2,6DIP 1138 H H H CD3 H H 2,6DMB 1139 H H H CD3 H H CD3 1140 H H H CD3 H H CH3 1141 H H H CD3 H H H 1142 H H H CD3 H H i-Pr 1143 H H H CD3 H i-Pr H 1144 H H H CD3 i-Pr H H 1145 H H H CH3 2,6DIP H H 1146 H H H CH3 2,6DMB H H 1147 H H H CH3 CD3 H H 1148 H H H CH3 CH3 H H 1149 H H H CH3 H 2,6DIP H 1150 H H H CH3 H 2,6DMB H 1151 H H H CH3 H CD3 H 1152 H H H CH3 H CH3 H 1153 H H H CH3 H H 2,6DIP 1154 H H H CH3 H H 2,6DMB 1155 H H H CH3 H H CD3 1156 H H H CH3 H H CH3 1157 H H H CH3 H H H 1158 H H H CH3 H H i-Pr 1159 H H H CH3 H i-Pr H 1160 H H H CH3 i-Pr H H 1161 H H H H 2,6DIP H CD3 1162 H H H H 2,6DIP H CH3 1163 H H H H 2,6DIP H H 1164 H H H H 2,6DMB H CD3 1165 H H H H 2,6DMB H CH3 1166 H H H H 2,6DMB H H 1167 H H H H CD3 CD3 H 1168 H H H H CD3 CH3 H 1169 H H H H CD3 H 2,6DIP 1170 H H H H CD3 H 2,6DMB 1171 H H H H CD3 H CD3 1172 H H H H CD3 H CH3 1173 H H H H CD3 H H 1174 H H H H CD3 H i-Pr 1175 H H H H CD3 i-Pr H 1176 H H H H CH3 CD3 H 1177 H H H H CH3 CH3 H 1178 H H H H CH3 H 2,6DIP 1179 H H H H CH3 H 2,6DMB 1180 H H H H CH3 H CD3 1181 H H H H CH3 H CH3 1182 H H H H CH3 H H 1183 H H H H CH3 H i-Pr 1184 H H H H CH3 i-Pr H 1185 H H H H H 2,6DIP H 1186 H H H H H 2,6DMB H 1187 H H H H H CD3 CD3 1188 H H H H H CD3 CH3 1189 H H H H H CD3 H 1190 H H H H H CD3 i-Pr 1191 H H H H H CH3 CD3 1192 H H H H H CH3 CH3 1193 H H H H H CH3 H 1194 H H H H H CH3 i-Pr 1195 H H H H H H 2,6DIP 1196 H H H H H H 2,6DMB 1197 H H H H H H CD3 1198 H H H H H H CH3 1199 H H H H H H H 1200 H H H H H H i-Pr 1201 H H H H H i-Pr CD3 1202 H H H H H i-Pr CH3 1203 H H H H H i-Pr H 1204 H H H H i-Pr CD3 H 1205 H H H H i-Pr CH3 H 1206 H H H H i-Pr H CD3 1207 H H H H i-Pr H CH3 1208 H H H H i-Pr H H 1209 H H H i-Pr CD3 H H 1210 H H H i-Pr CH3 H H 1211 H H H i-Pr H CD3 H 1212 H H H i-Pr H CH3 H 1213 H H H i-Pr H H CD3 1214 H H H i-Pr H H CH3 1215 H H H i-Pr H H H 1216 H H i-Pr CD3 H H H 1217 H H i-Pr CH3 H H H 1218 H H i-Pr H CD3 H H 1219 H H i-Pr H CH3 H H 1220 H H i-Pr H H CD3 H 1221 H H i-Pr H H CH3 H 1222 H H i-Pr H H H CD3 1223 H H i-Pr H H H CH3 1224 H H i-Pr H H H H 1225 H i-Pr CD3 H H H H 1226 H i-Pr CH3 H H H H 1227 H i-Pr H CD3 H H H 1228 H i-Pr H CH3 H H H 1229 H i-Pr H H CD3 H H 1230 H i-Pr H H CH3 H H 1231 H i-Pr H H H CD3 H 1232 H i-Pr H H H CH3 H 1233 H i-Pr H H H H CD3 1234 H i-Pr H H H H CH3 1235 H i-Pr H H H H H 1236 i-Pr CD3 H H H H H 1237 i-Pr CH3 H H H H H 1238 i-Pr H CD3 H H H H 1239 i-Pr H CH3 H H H H 1240 i-Pr H H CD3 H H H 1241 i-Pr H H CH3 H H H 1242 i-Pr H H H CD3 H H 1243 i-Pr H H H CH3 H H 1244 i-Pr H H H H CD3 H 1245 i-Pr H H H H CH3 H 1246 i-Pr H H H H H CD3 1247 i-Pr H H H H H CH3 1248 i-Pr H H H H H H

wherein 2,6DIP is 2,6-diisopropyl benzene, 2,6DMB is 2,6-dimethyl benzene, and i-Pr is isopropyl.
 7. The compound of claim 6, wherein the compound is Compound Ax having the formula Ir(L_(Ai))₃; and wherein x=i; i is an integer from 1 to
 1248. 8. The compound of claim 6, wherein the compound is the Compound By having the formula Ir(L_(Ai))(L_(j))₂ or Compound Cz having the formula Ir(L_(Ai))₂(L_(j)); wherein y=39i+j−39; i is an integer from 1 to 1248, and j is an integer from 1 to 20 or from 22 to 39; wherein z=39i+j−39; i is an integer from 1 to 1248, and j is an integer from 1 to 20 or from 22 to 39; and wherein L₁ to L₂₀ and L₂₂ to L₃₉ have the following structure:


9. The compound of claim 1, wherein the compound has a formula of M(L_(A))_(n)(L_(B))_(m-n); wherein M is Ir; L_(B) is a bidentate ligand; and wherein m is 3 and n is 1, 2, or
 3. 10. The compound of claim 9, wherein the compound has a formula selected from the group consisting of Ir(L_(A))₃, Ir(L_(A))(L_(B))₂, and Ir(L_(A))₂(L_(B)), wherein L_(B) is different from L_(A).
 11. The compound of claim 9, wherein L_(B) is selected from the group consisting of:

wherein each X¹ to X¹³ are independently selected from the group consisting of carbon and nitrogen; wherein X is selected from the group consisting of BR′, NR′, PR′, O, S, Se, C═O, S═O, SO₂, CR′R″, SiR′R″, and GeR′R″; wherein R′ and R″ are optionally fused or joined to form a ring; wherein each R_(a), R_(b), R_(c), and R_(d) may represent from mono substitution to the possible maximum number of substitution, or no substitution; wherein R′, R″, R_(a), R_(b), R_(c), and R_(d) are each independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; wherein any two adjacent substituents of R_(a), R_(b), R_(c), and R_(d) are optionally fused or joined to form a ring; and wherein any of R_(a), R_(b), R_(c), and R_(d) is optionally linked to L_(A) or another of L_(B) to form a tetradentate or hexadentate ligand.
 12. An organic light emitting device (OLED) comprising: an anode; a cathode; and an organic layer, disposed between the anode and the cathode, comprising a compound comprising a ligand L_(A) represented by Formula I:

wherein ring A is a 6-membered carbocyclic or heterocyclic ring; wherein Z is nitrogen or carbon; wherein R¹ and R³ each represent from mono-substitution to the possible maximum number of substitution, or no substitution; wherein Z¹, Z², Z³, and Z⁴ are each independently selected from the group consisting of nitrogen and carbon; wherein at least one of Z¹, Z², Z³, and Z⁴ is nitrogen; wherein X is selected from the group consisting of O, S, and Se; wherein each R¹ and R³ are independently selected from the group consisting of: (i) hydrogen, deuterium, halide, straight chain alkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; or (ii) hydrogen, deuterium, halide, isopropyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; wherein any adjacent substituents of R¹ and R³ are optionally joined or fused into a ring; wherein the ligand L_(A) is coordinated to Ir; and wherein the ligand L_(A) is optionally linked with other ligands to comprise a tridentate, tetradentate, pentadentate or hexadentate ligand.
 13. A device comprising the OLED of claim 12 which is selected from the group consisting of a consumer product, an electronic component module, and a lighting panel.
 14. The OLED of claim 12, wherein the organic layer is an emissive layer and the compound is an emissive dopant or a non-emissive dopant.
 15. The OLED of claim 12, wherein the organic layer further comprises a host, wherein host comprises at least one chemical group selected from the group consisting of triphenylene, carbazole, dibenzothiophene, dibenzofuran, dibenzoselenophene, azatriphenylene, azacarbazole, aza-dibenzothiophene, aza-dibenzofuran, and aza-dibenzoselenophene.
 16. The OLED of claim 12, wherein the organic layer further comprises a host, wherein the host is selected from the group consisting of:

and combinations thereof.
 17. A formulation comprising a compound comprising a ligand L_(A) represented by Formula I:

wherein ring A is a 6-membered carbocyclic or heterocyclic ring; wherein Z is nitrogen or carbon; wherein R¹ and R³ each represent from mono-substitution to the possible maximum number of substitution, or no substitution; wherein Z¹, Z², Z³, and Z⁴ are each independently selected from the group consisting of nitrogen and carbon; wherein at least one of Z¹, Z², Z³, and Z⁴ is nitrogen; wherein X is selected from the group consisting of O, S, and Se; wherein each R¹ and R³ are independently selected from the group consisting of: (i) hydrogen, deuterium, halide, straight chain alkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; or (ii) hydrogen, deuterium, halide, isopropyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; wherein any adjacent substituents of R¹ and R³ are optionally joined or fused into a ring; wherein the ligand L_(A) is coordinated to Ir; and wherein the ligand L_(A) is optionally linked with other ligands to comprise a tridentate, tetradentate, pentadentate or hexadentate ligand. 